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Year Number of Results
1936 1
1938 1
1945 1
1946 1
1947 1
1948 5
1950 5
1951 1
1952 1
1953 4
1954 1
1955 3
1956 2
1957 4
1959 4
1960 5
1961 7
1962 7
1963 18
1964 25
1965 15
1966 9
1967 13
1968 19
1969 26
1970 20
1971 50
1972 56
1973 87
1974 100
1975 159
1976 167
1977 158
1978 156
1979 186
1980 199
1981 230
1982 240
1983 295
1984 390
1985 401
1986 430
1987 421
1988 511
1989 640
1990 675
1991 705
1992 886
1993 991
1994 1138
1995 1271
1996 1400
1997 1630
1998 1676
1999 1928
2000 2001
2001 2177
2002 2291
2003 2643
2004 3292
2005 3302
2006 3602
2007 3934
2008 4244
2009 4477
2010 5293
2011 5829
2012 6614
2013 7005
2014 7538
2015 8064
2016 8509
2017 8812
2018 9358
2019 10035
2020 10826
2021 11345
2022 10555
2023 10286
2024 11171
2025 12716
2026 7893

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182,146 results

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The following terms were not found in PubMed: cycle+cytotoxicity+Excoecaria, agallocha+flow, cytometry+MCF-7+cell, cycle+cytotoxicity+flow, cytometry+MCF-7
Page 1
Cancer cell-derived arginine fuels polyamine biosynthesis in tumor-associated macrophages to promote immune evasion.
Zhu Y, Zhou Z, Du X, Lin X, Liang ZM, Chen S, Sun Y, Wang Y, Na Z, Wu Z, Zhong J, Han B, Zhu X, Fu W, Li H, Luo ML, Hu H. Zhu Y, et al. Cancer Cell. 2025 Jun 9;43(6):1045-1060.e7. doi: 10.1016/j.ccell.2025.03.015. Epub 2025 Apr 3. Cancer Cell. 2025. PMID: 40185095
Here, we reveal that the metabolic interplay between cancer cells and macrophages plays a dominant role in arginine-driven breast cancer progression. ...Notably, this cancer cell-macrophage interaction overrides the arginine-mediated enhancement …
Here, we reveal that the metabolic interplay between cancer cells and macrophages plays a dominant role in arginine-driven breast …
Single-cell analyses reveal key immune cell subsets associated with response to PD-L1 blockade in triple-negative breast cancer.
Zhang Y, Chen H, Mo H, Hu X, Gao R, Zhao Y, Liu B, Niu L, Sun X, Yu X, Wang Y, Chang Q, Gong T, Guan X, Hu T, Qian T, Xu B, Ma F, Zhang Z, Liu Z. Zhang Y, et al. Cancer Cell. 2021 Dec 13;39(12):1578-1593.e8. doi: 10.1016/j.ccell.2021.09.010. Epub 2021 Oct 14. Cancer Cell. 2021. PMID: 34653365 Free article.
In triple-negative breast cancer (TNBC), the benefit of combining chemotherapy with checkpoint inhibitors is still not very clear. We utilize single-cell RNA- and ATAC-sequencing to examine the immune cell dynamics in 22 patients with advanced TNBC tre …
In triple-negative breast cancer (TNBC), the benefit of combining chemotherapy with checkpoint inhibitors is still not very cl …
Single-cell and spatial profiling identify three response trajectories to pembrolizumab and radiation therapy in triple negative breast cancer.
Shiao SL, Gouin KH 3rd, Ing N, Ho A, Basho R, Shah A, Mebane RH, Zitser D, Martinez A, Mevises NY, Ben-Cheikh B, Henson R, Mita M, McAndrew P, Karlan S, Giuliano A, Chung A, Amersi F, Dang C, Richardson H, Shon W, Dadmanesh F, Burnison M, Mirhadi A, Zumsteg ZS, Choi R, Davis M, Lee J, Rollins D, Martin C, Khameneh NH, McArthur H, Knott SRV. Shiao SL, et al. Cancer Cell. 2024 Jan 8;42(1):70-84.e8. doi: 10.1016/j.ccell.2023.12.012. Cancer Cell. 2024. PMID: 38194915 Free article.
Strategies are needed to better identify patients that will benefit from immunotherapy alone or who may require additional therapies like chemotherapy or radiotherapy to overcome resistance. Here we employ single-cell transcriptomics and spatial proteomics to profile tripl …
Strategies are needed to better identify patients that will benefit from immunotherapy alone or who may require additional therapies like ch …
Chronic stress increases metastasis via neutrophil-mediated changes to the microenvironment.
He XY, Gao Y, Ng D, Michalopoulou E, George S, Adrover JM, Sun L, Albrengues J, Daßler-Plenker J, Han X, Wan L, Wu XS, Shui LS, Huang YH, Liu B, Su C, Spector DL, Vakoc CR, Van Aelst L, Egeblad M. He XY, et al. Cancer Cell. 2024 Mar 11;42(3):474-486.e12. doi: 10.1016/j.ccell.2024.01.013. Epub 2024 Feb 22. Cancer Cell. 2024. PMID: 38402610 Free PMC article.
Chronic stress is associated with increased risk of metastasis and poor survival in cancer patients, yet the reasons are unclear. We show that chronic stress increases lung metastasis from disseminated cancer cells 2- to 4-fold in mice. ...Therefore, NETs could be t …
Chronic stress is associated with increased risk of metastasis and poor survival in cancer patients, yet the reasons are unclear. We …
Pan-cancer human brain metastases atlas at single-cell resolution.
Xing X, Zhong J, Biermann J, Duan H, Zhang X, Shi Y, Gao Y, He K, Zhai D, Luo F, Lai Y, Xiao F, Wang W, Wang M, Xu J, Liu H, Tang J, Chu L, Chen T, D'Souza EK, Caprio L, Ebel L, Biswas D, Cottarelli A, Mou Y, Izar B, Zhang N, Bai F. Xing X, et al. Cancer Cell. 2025 Jul 14;43(7):1242-1260.e9. doi: 10.1016/j.ccell.2025.03.025. Epub 2025 Apr 10. Cancer Cell. 2025. PMID: 40215980 Free PMC article.
However, advances in our understanding of BrM have been hampered by the constrained sample size and resolution of BrM profiling studies. Here, we perform integrative single-cell RNA sequencing analysis on 108 BrM samples and 111 primary tumor (PTs) samples to investigate t …
However, advances in our understanding of BrM have been hampered by the constrained sample size and resolution of BrM profiling studies. Her …
Chemotherapy awakens dormant cancer cells in lung by inducing neutrophil extracellular traps.
He D, Wu Q, Tian P, Liu Y, Jia Z, Li Z, Wang Y, Jin Y, Luo W, Li L, Zhang P, Jin Q, Zhao W, Hu W, Liang Y, Zhou B, Yang Q, Jiang YZ, Shao ZM, Hu G. He D, et al. Cancer Cell. 2025 Sep 8;43(9):1622-1636.e7. doi: 10.1016/j.ccell.2025.06.007. Epub 2025 Jul 3. Cancer Cell. 2025. PMID: 40614736
Here, we demonstrate that chemotherapeutic drugs, including doxorubicin and cisplatin, enhance proliferation and lung metastasis of dormant breast cancer cells. Using a recombinase-based dormancy tracing system, DormTracer, we confirm chemotherapy-induced reactivati …
Here, we demonstrate that chemotherapeutic drugs, including doxorubicin and cisplatin, enhance proliferation and lung metastasis of dormant …
Distinct cellular mechanisms underlie chemotherapies and PD-L1 blockade combinations in triple-negative breast cancer.
Zhang Y, Chen H, Mo H, Zhao N, Sun X, Liu B, Gao R, Xu B, Zhang Z, Liu Z, Ma F. Zhang Y, et al. Cancer Cell. 2025 Mar 10;43(3):446-463.e7. doi: 10.1016/j.ccell.2025.01.007. Epub 2025 Feb 6. Cancer Cell. 2025. PMID: 39919737 Free article.
Combining immune checkpoint blockade (ICB) with chemotherapy shows promise for treating triple-negative breast cancer (TNBC), though the mechanisms remain incompletely understood. Here, we integrate published and new single-cell RNA sequencing (scRNA-seq) dat …
Combining immune checkpoint blockade (ICB) with chemotherapy shows promise for treating triple-negative breast cancer (TNBC), …
Overcoming Endocrine Resistance in Breast Cancer.
Hanker AB, Sudhan DR, Arteaga CL. Hanker AB, et al. Cancer Cell. 2020 Apr 13;37(4):496-513. doi: 10.1016/j.ccell.2020.03.009. Cancer Cell. 2020. PMID: 32289273 Free PMC article. Review.
Estrogen receptor-positive (ER(+)) breast cancer is the most common breast cancer subtype. Treatment of ER(+) breast cancer comprises interventions that suppress estrogen production and/or target the ER directly (overall labeled as endocr …
Estrogen receptor-positive (ER(+)) breast cancer is the most common breast cancer subtype. Treatment of ER(+) …
Inhibiting intracellular CD28 in cancer cells enhances antitumor immunity and overcomes anti-PD-1 resistance via targeting PD-L1.
Yang Z, Liu X, Zhu J, Chai Y, Cong B, Li B, Gao W, Hu Y, Wen M, Liu Y, Fu L, Cao X. Yang Z, et al. Cancer Cell. 2025 Jan 13;43(1):86-102.e10. doi: 10.1016/j.ccell.2024.11.008. Epub 2024 Dec 12. Cancer Cell. 2025. PMID: 39672166 Free article.
Furthermore, high expression of cancer cell CD28 in human TNBC tissues correlated with elevated PD-L1 expression, less CD8(+) T cell infiltration, and poor prognosis. Mechanistically, intracellular CD28 directly bound to Cd274 mRNA and recruited spliceosomal …
Furthermore, high expression of cancer cell CD28 in human TNBC tissues correlated with elevated PD-L1 expression, less CD8(+) …
182,146 results
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