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34 results
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Prediction of drug tissue to plasma concentration ratios using a measured volume of distribution in combination with lipophilicity.
Jansson R, Bredberg U, Ashton M. Jansson R, et al. Among authors: bredberg u. J Pharm Sci. 2008 Jun;97(6):2324-39. doi: 10.1002/jps.21130. J Pharm Sci. 2008. PMID: 17724666
Metabolic stability for drug discovery and development: pharmacokinetic and biochemical challenges.
Masimirembwa CM, Bredberg U, Andersson TB. Masimirembwa CM, et al. Among authors: bredberg u. Clin Pharmacokinet. 2003;42(6):515-28. doi: 10.2165/00003088-200342060-00002. Clin Pharmacokinet. 2003. PMID: 12793837 Review.
Optimal experimental design for assessment of enzyme kinetics in a drug discovery screening environment.
Sjögren E, Nyberg J, Magnusson MO, Lennernäs H, Hooker A, Bredberg U. Sjögren E, et al. Among authors: bredberg u. Drug Metab Dispos. 2011 May;39(5):858-63. doi: 10.1124/dmd.110.037309. Epub 2011 Feb 2. Drug Metab Dispos. 2011. PMID: 21289074
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods.
Fridén M, Bergström F, Wan H, Rehngren M, Ahlin G, Hammarlund-Udenaes M, Bredberg U. Fridén M, et al. Among authors: bredberg u. Drug Metab Dispos. 2011 Mar;39(3):353-62. doi: 10.1124/dmd.110.035998. Epub 2010 Dec 13. Drug Metab Dispos. 2011. PMID: 21149540
Improved measurement of drug exposure in the brain using drug-specific correction for residual blood.
Fridén M, Ljungqvist H, Middleton B, Bredberg U, Hammarlund-Udenaes M. Fridén M, et al. Among authors: bredberg u. J Cereb Blood Flow Metab. 2010 Jan;30(1):150-61. doi: 10.1038/jcbfm.2009.200. Epub 2009 Sep 16. J Cereb Blood Flow Metab. 2010. PMID: 19756019 Free PMC article.
The multiple depletion curves method provides accurate estimates of intrinsic clearance (CLint), maximum velocity of the metabolic reaction (Vmax), and Michaelis constant (Km): accuracy and robustness evaluated through experimental data and Monte Carlo simulations.
Sjögren E, Lennernäs H, Andersson TB, Gråsjö J, Bredberg U. Sjögren E, et al. Among authors: bredberg u. Drug Metab Dispos. 2009 Jan;37(1):47-58. doi: 10.1124/dmd.108.021477. Epub 2008 Sep 29. Drug Metab Dispos. 2009. PMID: 18824525
In vitro methods for estimating unbound drug concentrations in the brain interstitial and intracellular fluids.
Fridén M, Gupta A, Antonsson M, Bredberg U, Hammarlund-Udenaes M. Fridén M, et al. Among authors: bredberg u. Drug Metab Dispos. 2007 Sep;35(9):1711-9. doi: 10.1124/dmd.107.015222. Epub 2007 Jun 25. Drug Metab Dispos. 2007. PMID: 17591680
Model-based drug discovery: implementation and impact.
Visser SA, Aurell M, Jones RD, Schuck VJ, Egnell AC, Peters SA, Brynne L, Yates JW, Jansson-Löfmark R, Tan B, Cooke M, Barry ST, Hughes A, Bredberg U. Visser SA, et al. Among authors: bredberg u. Drug Discov Today. 2013 Aug;18(15-16):764-75. doi: 10.1016/j.drudis.2013.05.012. Epub 2013 May 29. Drug Discov Today. 2013. PMID: 23726890 Review.
Development of a high-throughput brain slice method for studying drug distribution in the central nervous system.
Fridén M, Ducrozet F, Middleton B, Antonsson M, Bredberg U, Hammarlund-Udenaes M. Fridén M, et al. Among authors: bredberg u. Drug Metab Dispos. 2009 Jun;37(6):1226-33. doi: 10.1124/dmd.108.026377. Epub 2009 Mar 19. Drug Metab Dispos. 2009. PMID: 19299522
Estimation of bioavailability on a single occasion after semisimultaneous drug administration.
Karlsson MO, Bredberg U. Karlsson MO, et al. Among authors: bredberg u. Pharm Res. 1989 Sep;6(9):817-21. doi: 10.1023/a:1015939917646. Pharm Res. 1989. PMID: 2813280
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