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DNA methyltransferase Dnmt1 associates with histone deacetylase activity.
Fuks F, Burgers WA, Brehm A, Hughes-Davies L, Kouzarides T. Fuks F, et al. Among authors: brehm a. Nat Genet. 2000 Jan;24(1):88-91. doi: 10.1038/71750. Nat Genet. 2000. PMID: 10615135
The DNA methyltransferase Dnmt1 is responsible for cytosine methylation in mammals and has a role in gene silencing. DNA methylation represses genes partly by recruitment of the methyl-CpG-binding protein MeCP2, which in turn recruits a histone deacetylase activity. …
The DNA methyltransferase Dnmt1 is responsible for cytosine methylation in mammals and has a role in gene silencing. DNA methylation …
Autorepression of the human cytomegalovirus major immediate-early promoter/enhancer at late times of infection is mediated by the recruitment of chromatin remodeling enzymes by IE86.
Reeves M, Murphy J, Greaves R, Fairley J, Brehm A, Sinclair J. Reeves M, et al. Among authors: brehm a. J Virol. 2006 Oct;80(20):9998-10009. doi: 10.1128/JVI.01297-06. J Virol. 2006. PMID: 17005678 Free PMC article.
A relatively promiscuous transactivator of viral early and late gene transcription, IE86 also acts during infection to negatively regulate its own promoter via direct binding to a 14-bp palindromic IE86-binding site, the cis repression sequence (crs), located betwee
A relatively promiscuous transactivator of viral early and late gene transcription, IE86 also acts during infection to negatively reg
Tramtrack69 interacts with the dMi-2 subunit of the Drosophila NuRD chromatin remodelling complex.
Murawsky CM, Brehm A, Badenhorst P, Lowe N, Becker PB, Travers AA. Murawsky CM, et al. Among authors: brehm a. EMBO Rep. 2001 Dec;2(12):1089-94. doi: 10.1093/embo-reports/kve252. Epub 2001 Nov 21. EMBO Rep. 2001. PMID: 11743021 Free PMC article.
dMi-2, the ATPase subunit of the Drosophila nucleosome remodelling and histone deacetylation (dNuRD) complex, was identified in a two-hybrid screen as an interacting partner of the transcriptional repressor, Tramtrack69 (Ttk69). ...Both dMi-2 and Ttk69 co-localize at a
dMi-2, the ATPase subunit of the Drosophila nucleosome remodelling and histone deacetylation (dNuRD) complex, was identified in a two …
Regulation of E2F1 activity by acetylation.
Martínez-Balbás MA, Bauer UM, Nielsen SJ, Brehm A, Kouzarides T. Martínez-Balbás MA, et al. Among authors: brehm a. EMBO J. 2000 Feb 15;19(4):662-71. doi: 10.1093/emboj/19.4.662. EMBO J. 2000. PMID: 10675335 Free PMC article.
Phosphorylation of RB at the G(1)/S boundary generates a pool of 'free' E2F, which then stimulates transcription of S-phase genes. ...These results identify acetylation as a novel regulatory modification that stimulates E2F1's activation functions....
Phosphorylation of RB at the G(1)/S boundary generates a pool of 'free' E2F, which then stimulates transcription of S-phase genes. .. …
The cell cycle-regulating transcription factors E2F-RB.
Brehm A, Miska E, Reid J, Bannister A, Kouzarides T. Brehm A, et al. Br J Cancer. 1999 Jul;80 Suppl 1:38-41. Br J Cancer. 1999. PMID: 10466760 Review. No abstract available.
Retinoblastoma protein meets chromatin.
Brehm A, Kouzarides T. Brehm A, et al. Trends Biochem Sci. 1999 Apr;24(4):142-5. doi: 10.1016/s0968-0004(99)01368-7. Trends Biochem Sci. 1999. PMID: 10322419 Review.
These findings point towards a link between chromatin regulation and cancer....
These findings point towards a link between chromatin regulation and cancer....
Retinoblastoma protein recruits histone deacetylase to repress transcription.
Brehm A, Miska EA, McCance DJ, Reid JL, Bannister AJ, Kouzarides T. Brehm A, et al. Nature. 1998 Feb 5;391(6667):597-601. doi: 10.1038/35404. Nature. 1998. PMID: 9468139
Rb binds to the activation domain of E2F and then actively represses the promoter by a mechanism that is poorly understood. Here we show that Rb associates with a histone deacetylase, HDAC1, through the Rb 'pocket' domain. ...Inhibition of histone deacetylase activi …
Rb binds to the activation domain of E2F and then actively represses the promoter by a mechanism that is poorly understood. Here we s …
The E7 oncoprotein associates with Mi2 and histone deacetylase activity to promote cell growth.
Brehm A, Nielsen SJ, Miska EA, McCance DJ, Reid JL, Bannister AJ, Kouzarides T. Brehm A, et al. EMBO J. 1999 May 4;18(9):2449-58. doi: 10.1093/emboj/18.9.2449. EMBO J. 1999. PMID: 10228159 Free PMC article.
Using a genetic screen, we identify Mi2beta, a component of the recently identified NURD histone deacetylase complex, as a protein that binds directly to the E7 zinc finger. A zinc finger point mutant which is unable to bind Mi2beta and histone deacety …
Using a genetic screen, we identify Mi2beta, a component of the recently identified NURD histone deacetylase complex, as a
Temporal recruitment of the mSin3A-histone deacetylase corepressor complex to the ETS domain transcription factor Elk-1.
Yang SH, Vickers E, Brehm A, Kouzarides T, Sharrocks AD. Yang SH, et al. Among authors: brehm a. Mol Cell Biol. 2001 Apr;21(8):2802-14. doi: 10.1128/MCB.21.8.2802-2814.2001. Mol Cell Biol. 2001. PMID: 11283259 Free PMC article.
The transcriptional status of eukaryotic genes is determined by a balance between activation and repression mechanisms. The nuclear hormone receptors represent classical examples of transcription factors that can regulate this balance by recruiting corepressor and coactiva …
The transcriptional status of eukaryotic genes is determined by a balance between activation and repression mechanisms. The nuclear h …
Transcriptional repression by the insulator protein CTCF involves histone deacetylases.
Lutz M, Burke LJ, Barreto G, Goeman F, Greb H, Arnold R, Schultheiss H, Brehm A, Kouzarides T, Lobanenkov V, Renkawitz R. Lutz M, et al. Among authors: brehm a. Nucleic Acids Res. 2000 Apr 15;28(8):1707-13. doi: 10.1093/nar/28.8.1707. Nucleic Acids Res. 2000. PMID: 10734189 Free PMC article.
The highly conserved zinc-finger protein, CTCF, is a candidate tumor suppressor protein that binds to highly divergent DNA sequences. ...
The highly conserved zinc-finger protein, CTCF, is a candidate tumor suppressor protein that binds to highly divergent DNA sequences. …
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