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The inhibition of tyrosine kinase receptor signalling in leiomyosarcoma cells using the small molecule kinase inhibitor PTK787/ZK222584 (Vatalanib®).
Gaumann AK, Drexler HC, Lang SA, Stoeltzing O, Diermeier-Daucher S, Buchdunger E, Wood J, Bold G, Breier G. Gaumann AK, et al. Int J Oncol. 2014 Dec;45(6):2267-77. doi: 10.3892/ijo.2014.2683. Epub 2014 Sep 29. Int J Oncol. 2014. PMID: 25340839 Free PMC article.
Spatial regulation of VEGF receptor endocytosis in angiogenesis.
Nakayama M, Nakayama A, van Lessen M, Yamamoto H, Hoffmann S, Drexler HC, Itoh N, Hirose T, Breier G, Vestweber D, Cooper JA, Ohno S, Kaibuchi K, Adams RH. Nakayama M, et al. Nat Cell Biol. 2013 Mar;15(3):249-60. doi: 10.1038/ncb2679. Epub 2013 Jan 27. Nat Cell Biol. 2013. PMID: 23354168 Free PMC article.
Ablation of cholesterol biosynthesis in neural stem cells increases their VEGF expression and angiogenesis but causes neuron apoptosis.
Saito K, Dubreuil V, Arai Y, Wilsch-Bräuninger M, Schwudke D, Saher G, Miyata T, Breier G, Thiele C, Shevchenko A, Nave KA, Huttner WB. Saito K, et al. Proc Natl Acad Sci U S A. 2009 May 19;106(20):8350-5. doi: 10.1073/pnas.0903541106. Epub 2009 May 5. Proc Natl Acad Sci U S A. 2009. PMID: 19416849 Free PMC article.
Lack of vascular endothelial growth factor receptor-2/Flk1 signaling does not affect substantia nigra development.
Hermann A, Loewenbrück KF, Boldt Ä, Fiedler C, Maisel M, Kalucka J, Schwarz J, Breier G, Storch A. Hermann A, et al. Neurosci Lett. 2013 Oct 11;553:142-7. doi: 10.1016/j.neulet.2013.08.031. Epub 2013 Aug 29. Neurosci Lett. 2013. PMID: 23994060
Endothelium-specific Cre recombinase activity in flk-1-Cre transgenic mice.
Licht AH, Raab S, Hofmann U, Breier G. Licht AH, et al. Dev Dyn. 2004 Feb;229(2):312-8. doi: 10.1002/dvdy.10416. Dev Dyn. 2004. PMID: 14745955
Impaired brain angiogenesis and neuronal apoptosis induced by conditional homozygous inactivation of vascular endothelial growth factor.
Raab S, Beck H, Gaumann A, Yüce A, Gerber HP, Plate K, Hammes HP, Ferrara N, Breier G. Raab S, et al. Thromb Haemost. 2004 Mar;91(3):595-605. doi: 10.1160/TH03-09-0582. Thromb Haemost. 2004. PMID: 14983237
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