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CCR5 structural plasticity shapes HIV-1 phenotypic properties.
Colin P, Zhou Z, Staropoli I, Garcia-Perez J, Gasser R, Armani-Tourret M, Benureau Y, Gonzalez N, Jin J, Connell BJ, Raymond S, Delobel P, Izopet J, Lortat-Jacob H, Alcami J, Arenzana-Seisdedos F, Brelot A, Lagane B. Colin P, et al. Among authors: brelot a. PLoS Pathog. 2018 Dec 6;14(12):e1007432. doi: 10.1371/journal.ppat.1007432. eCollection 2018 Dec. PLoS Pathog. 2018. PMID: 30521629 Free PMC article.
HIV-1 exploits CCR5 conformational heterogeneity to escape inhibition by chemokines.
Colin P, Bénureau Y, Staropoli I, Wang Y, Gonzalez N, Alcami J, Hartley O, Brelot A, Arenzana-Seisdedos F, Lagane B. Colin P, et al. Among authors: brelot a. Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9475-80. doi: 10.1073/pnas.1222205110. Epub 2013 May 21. Proc Natl Acad Sci U S A. 2013. PMID: 23696662 Free PMC article.
Targeting spare CC chemokine receptor 5 (CCR5) as a principle to inhibit HIV-1 entry.
Jin J, Colin P, Staropoli I, Lima-Fernandes E, Ferret C, Demir A, Rogée S, Hartley O, Randriamampita C, Scott MG, Marullo S, Sauvonnet N, Arenzana-Seisdedos F, Lagane B, Brelot A. Jin J, et al. Among authors: brelot a. J Biol Chem. 2014 Jul 4;289(27):19042-52. doi: 10.1074/jbc.M114.559831. Epub 2014 May 22. J Biol Chem. 2014. PMID: 24855645 Free PMC article.
Targeting CCR5 trafficking to inhibit HIV-1 infection.
Boncompain G, Herit F, Tessier S, Lescure A, Del Nery E, Gestraud P, Staropoli I, Fukata Y, Fukata M, Brelot A, Niedergang F, Perez F. Boncompain G, et al. Among authors: brelot a. Sci Adv. 2019 Oct 16;5(10):eaax0821. doi: 10.1126/sciadv.aax0821. eCollection 2019 Oct. Sci Adv. 2019. PMID: 31663020 Free PMC article.
Low CCR5 expression protects HIV-specific CD4+ T cells of elite controllers from viral entry.
Claireaux M, Robinot R, Kervevan J, Patgaonkar M, Staropoli I, Brelot A, Nouël A, Gellenoncourt S, Tang X, Héry M, Volant S, Perthame E, Avettand-Fenoël V, Buchrieser J, Cokelaer T, Bouchier C, Ma L, Boufassa F, Hendou S, Libri V, Hasan M, Zucman D, de Truchis P, Schwartz O, Lambotte O, Chakrabarti LA. Claireaux M, et al. Among authors: brelot a. Nat Commun. 2022 Jan 26;13(1):521. doi: 10.1038/s41467-022-28130-0. Nat Commun. 2022. PMID: 35082297 Free PMC article.
Discovery of Bis-Imidazoline Derivatives as New CXCR4 Ligands.
Zhou Z, Staropoli I, Brelot A, Suzanne P, Lesnard A, Fontaine F, Perato S, Rault S, Helynck O, Arenzana-Seisdedos F, Sopkova-de Oliveira Santos J, Lagane B, Munier-Lehmann H, Colin P. Zhou Z, et al. Among authors: brelot a. Molecules. 2023 Jan 24;28(3):1156. doi: 10.3390/molecules28031156. Molecules. 2023. PMID: 36770826 Free PMC article.
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