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Identification of the binding interfaces on CheY for two of its targets, the phosphatase CheZ and the flagellar switch protein fliM.
McEvoy MM, Bren A, Eisenbach M, Dahlquist FW. McEvoy MM, et al. Among authors: bren a. J Mol Biol. 1999 Jun 25;289(5):1423-33. doi: 10.1006/jmbi.1999.2830. J Mol Biol. 1999. PMID: 10373376
CheY is the response regulator protein serving as a phosphorylation-dependent switch in the bacterial chemotaxis signal transduction pathway. ...There is a significant enhancement of the binding of these peptides to the phosphorylated form of CheY, suggesting that t …
CheY is the response regulator protein serving as a phosphorylation-dependent switch in the bacterial chemotaxis signal transduction …
Surface growth of a motile bacterial population resembles growth in a chemostat.
Koster DA, Mayo A, Bren A, Alon U. Koster DA, et al. Among authors: bren a. J Mol Biol. 2012 Dec 7;424(3-4):180-91. doi: 10.1016/j.jmb.2012.09.005. Epub 2012 Sep 20. J Mol Biol. 2012. PMID: 23000812
By considering not only the advancing population but also the fraction that lags behind, we propose a growth model that relates spatial distribution, motility and growth rate. This model, that is similar to bacterial growth in a chemostat predicts that the fraction …
By considering not only the advancing population but also the fraction that lags behind, we propose a growth model that relates spati …
Negative auto-regulation increases the input dynamic-range of the arabinose system of Escherichia coli.
Madar D, Dekel E, Bren A, Alon U. Madar D, et al. Among authors: bren a. BMC Syst Biol. 2011 Jul 12;5:111. doi: 10.1186/1752-0509-5-111. BMC Syst Biol. 2011. PMID: 21749723 Free PMC article.
One of the most common network motifs is negative auto-regulation, in which a transcription factor represses its own production. ...Here we ask whether negative auto-regulation preserves this function also in the context of a natural system, where it is embedded wit …
One of the most common network motifs is negative auto-regulation, in which a transcription factor represses its own production. ...H …
Promoters maintain their relative activity levels under different growth conditions.
Keren L, Zackay O, Lotan-Pompan M, Barenholz U, Dekel E, Sasson V, Aidelberg G, Bren A, Zeevi D, Weinberger A, Alon U, Milo R, Segal E. Keren L, et al. Among authors: bren a. Mol Syst Biol. 2013 Oct 29;9:701. doi: 10.1038/msb.2013.59. Mol Syst Biol. 2013. PMID: 24169404 Free PMC article.
We show that in both organisms 60-90% of promoters change their expression between conditions by a constant global scaling factor that depends only on the conditions and not on the promoter's identity. ...We present a parameter-free passive resource allocation model …
We show that in both organisms 60-90% of promoters change their expression between conditions by a constant global scaling factor tha …
The incoherent feed-forward loop can generate non-monotonic input functions for genes.
Kaplan S, Bren A, Dekel E, Alon U. Kaplan S, et al. Among authors: bren a. Mol Syst Biol. 2008;4:203. doi: 10.1038/msb.2008.43. Epub 2008 Jul 15. Mol Syst Biol. 2008. PMID: 18628744 Free PMC article.
This motif was shown to act as a pulse generator and response accelerator of gene expression. Here we consider an additional function of this motif: the I1-FFL can generate a non-monotonic dependence of gene expression on the input signal. ...Theoretical analysis su …
This motif was shown to act as a pulse generator and response accelerator of gene expression. Here we consider an additional function …
Diverse two-dimensional input functions control bacterial sugar genes.
Kaplan S, Bren A, Zaslaver A, Dekel E, Alon U. Kaplan S, et al. Among authors: bren a. Mol Cell. 2008 Mar 28;29(6):786-92. doi: 10.1016/j.molcel.2008.01.021. Mol Cell. 2008. PMID: 18374652 Free PMC article.
Furthermore, most of the input functions show separation of variables, in the sense that they can be described as the product of simple functions that depend on a single input. ...
Furthermore, most of the input functions show separation of variables, in the sense that they can be described as the product of simple func …
Regulation of phosphatase activity in bacterial chemotaxis.
Blat Y, Gillespie B, Bren A, Dahlquist FW, Eisenbach M. Blat Y, et al. Among authors: bren a. J Mol Biol. 1998 Dec 11;284(4):1191-9. doi: 10.1006/jmbi.1998.2224. J Mol Biol. 1998. PMID: 9837737
It is controlled by changes in the phosphorylation level of the chemotactic response regulator, CheY, mediated by a histidine kinase (CheA) and a specific phosphatase (CheZ). ...This novel kind of interplay between a response regulator and its phosphatase may …
It is controlled by changes in the phosphorylation level of the chemotactic response regulator, CheY, mediated by a histidine kinase …
Signal termination in bacterial chemotaxis: CheZ mediates dephosphorylation of free rather than switch-bound CheY.
Bren A, Welch M, Blat Y, Eisenbach M. Bren A, et al. Proc Natl Acad Sci U S A. 1996 Sep 17;93(19):10090-3. doi: 10.1073/pnas.93.19.10090. Proc Natl Acad Sci U S A. 1996. PMID: 8816756 Free PMC article.
This biased rotation is terminated when CheY is dephosphorylated either spontaneously or, faster, by a specific phosphatase, CheZ. ...Nonspecific cross-linked CheY dimers, measured as a control, were dephosphorylated by CheZ. No significant binding between CheZ and …
This biased rotation is terminated when CheY is dephosphorylated either spontaneously or, faster, by a specific phosphatase, CheZ. .. …
The N terminus of the flagellar switch protein, FliM, is the binding domain for the chemotactic response regulator, CheY.
Bren A, Eisenbach M. Bren A, et al. J Mol Biol. 1998 May 8;278(3):507-14. doi: 10.1006/jmbi.1998.1730. J Mol Biol. 1998. PMID: 9600834
We cloned 17 fliM mutants, each defective in switching and having a point mutation at a different location, and then overexpressed and purified their products. ...To investigate whether the FliM domain that includes these three mutations is indeed the CheY-binding d …
We cloned 17 fliM mutants, each defective in switching and having a point mutation at a different location, and then overexpre …
Changing the direction of flagellar rotation in bacteria by modulating the ratio between the rotational states of the switch protein FliM.
Bren A, Eisenbach M. Bren A, et al. J Mol Biol. 2001 Sep 28;312(4):699-709. doi: 10.1006/jmbi.2001.4992. J Mol Biol. 2001. PMID: 11575925
We also carried out the inverse experiment, in which wild-type FliM was gradually expressed in a background of a clockwise fliM mutant. ...Such a situation might reflect a damping mechanism, which prevents a situation in which fluctuations in th …
We also carried out the inverse experiment, in which wild-type FliM was gradually expressed in a background of a clockwise fli …
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