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Restoration of first-phase insulin secretion by the imidazoline compound LY374284 in pancreatic islets of diabetic db/db mice.
Brenner MB, Gromada J, Efanov AM, Bokvist K, Mest HJ. Brenner MB, et al. Ann N Y Acad Sci. 2003 Dec;1009:332-40. doi: 10.1196/annals.1304.042. Ann N Y Acad Sci. 2003. PMID: 15028607
Activation of liver X receptors and retinoid X receptors induces growth arrest and apoptosis in insulin-secreting cells.
Wente W, Brenner MB, Zitzer H, Gromada J, Efanov AM. Wente W, et al. Among authors: brenner mb. Endocrinology. 2007 Apr;148(4):1843-9. doi: 10.1210/en.2006-1247. Epub 2006 Dec 28. Endocrinology. 2007. PMID: 17194744
Novel small molecule glucagon-like peptide-1 receptor agonist stimulates insulin secretion in rodents and from human islets.
Sloop KW, Willard FS, Brenner MB, Ficorilli J, Valasek K, Showalter AD, Farb TB, Cao JX, Cox AL, Michael MD, Gutierrez Sanfeliciano SM, Tebbe MJ, Coghlan MJ. Sloop KW, et al. Among authors: brenner mb. Diabetes. 2010 Dec;59(12):3099-107. doi: 10.2337/db10-0689. Epub 2010 Sep 7. Diabetes. 2010. PMID: 20823098 Free PMC article.
Ectonucleotidase NTPDase3 is abundant in pancreatic β-cells and regulates glucose-induced insulin secretion.
Syed SK, Kauffman AL, Beavers LS, Alston JT, Farb TB, Ficorilli J, Marcelo MC, Brenner MB, Bokvist K, Barrett DG, Efanov AM. Syed SK, et al. Among authors: brenner mb. Am J Physiol Endocrinol Metab. 2013 Nov 15;305(10):E1319-26. doi: 10.1152/ajpendo.00328.2013. Epub 2013 Oct 1. Am J Physiol Endocrinol Metab. 2013. PMID: 24085034
Sterol regulatory element-binding protein 1 mediates liver X receptor-beta-induced increases in insulin secretion and insulin messenger ribonucleic acid levels.
Zitzer H, Wente W, Brenner MB, Sewing S, Buschard K, Gromada J, Efanov AM. Zitzer H, et al. Among authors: brenner mb. Endocrinology. 2006 Aug;147(8):3898-905. doi: 10.1210/en.2005-1483. Epub 2006 Apr 27. Endocrinology. 2006. PMID: 16644917
A buffer temperature controlled perifusion system to study temperature dependence and kinetics of insulin secretion in MIN6 pseudoislets.
Brenner MB, Mest HJ. Brenner MB, et al. J Pharmacol Toxicol Methods. 2004 Jul-Aug;50(1):53-7. doi: 10.1016/j.vascn.2004.01.002. J Pharmacol Toxicol Methods. 2004. PMID: 15233968
Hepatic and glucagon-like peptide-1-mediated reversal of diabetes by glucagon receptor antisense oligonucleotide inhibitors.
Sloop KW, Cao JX, Siesky AM, Zhang HY, Bodenmiller DM, Cox AL, Jacobs SJ, Moyers JS, Owens RA, Showalter AD, Brenner MB, Raap A, Gromada J, Berridge BR, Monteith DK, Porksen N, McKay RA, Monia BP, Bhanot S, Watts LM, Michael MD. Sloop KW, et al. Among authors: brenner mb. J Clin Invest. 2004 Jun;113(11):1571-81. doi: 10.1172/JCI20911. J Clin Invest. 2004. PMID: 15173883 Free PMC article.
A novel glucokinase activator modulates pancreatic islet and hepatocyte function.
Efanov AM, Barrett DG, Brenner MB, Briggs SL, Delaunois A, Durbin JD, Giese U, Guo H, Radloff M, Gil GS, Sewing S, Wang Y, Weichert A, Zaliani A, Gromada J. Efanov AM, et al. Among authors: brenner mb. Endocrinology. 2005 Sep;146(9):3696-701. doi: 10.1210/en.2005-0377. Epub 2005 May 26. Endocrinology. 2005. PMID: 15919746
Fibroblast growth factor-21 improves pancreatic beta-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways.
Wente W, Efanov AM, Brenner M, Kharitonenkov A, Köster A, Sandusky GE, Sewing S, Treinies I, Zitzer H, Gromada J. Wente W, et al. Among authors: brenner m. Diabetes. 2006 Sep;55(9):2470-8. doi: 10.2337/db05-1435. Diabetes. 2006. PMID: 16936195
Engineering and characterization of the long-acting glucagon-like peptide-1 analogue LY2189265, an Fc fusion protein.
Glaesner W, Vick AM, Millican R, Ellis B, Tschang SH, Tian Y, Bokvist K, Brenner M, Koester A, Porksen N, Etgen G, Bumol T. Glaesner W, et al. Among authors: brenner m. Diabetes Metab Res Rev. 2010 May;26(4):287-96. doi: 10.1002/dmrr.1080. Diabetes Metab Res Rev. 2010. PMID: 20503261
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