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Methylation of selected CpGs in the human O6-methylguanine-DNA methyltransferase promoter region as a marker of gene silencing.
Danam RP, Qian XC, Howell SR, Brent TP. Danam RP, et al. Among authors: brent tp. Mol Carcinog. 1999 Feb;24(2):85-9. Mol Carcinog. 1999. PMID: 10078935
Hypermethylation of the gene promoter and enhancer region can regulate Fas expression and sensitivity in colon carcinoma.
Petak I, Danam RP, Tillman DM, Vernes R, Howell SR, Berczi L, Kopper L, Brent TP, Houghton JA. Petak I, et al. Among authors: brent tp. Cell Death Differ. 2003 Feb;10(2):211-7. doi: 10.1038/sj.cdd.4401132. Cell Death Differ. 2003. PMID: 12700649 Free article.
Protection and in vivo selection of hematopoietic stem cells using temozolomide, O6-benzylguanine, and an alkyltransferase-expressing retroviral vector.
Sawai N, Zhou S, Vanin EF, Houghton P, Brent TP, Sorrentino BP. Sawai N, et al. Among authors: brent tp. Mol Ther. 2001 Jan;3(1):78-87. doi: 10.1006/mthe.2000.0223. Mol Ther. 2001. PMID: 11162314 Free article.
Retroviral transfer of a bacterial alkyltransferase gene (ada) into human bone marrow cells protects against O6-benzylguanine plus 1, 3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity.
Marathi UK, Harris LC, Venable CC, Brent TP. Marathi UK, et al. Among authors: brent tp. Clin Cancer Res. 1997 Feb;3(2):301-7. Clin Cancer Res. 1997. PMID: 9815687
Retroviral transfer of a bacterial alkyltransferase gene into murine bone marrow protects against chloroethylnitrosourea cytotoxicity.
Harris LC, Marathi UK, Edwards CC, Houghton PJ, Srivastava DK, Vanin EF, Sorrentino BP, Brent TP. Harris LC, et al. Among authors: brent tp. Clin Cancer Res. 1995 Nov;1(11):1359-68. Clin Cancer Res. 1995. PMID: 9815932
1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine (VNP40101M): II. Role of O6-alkylguanine-DNA alkyltransferase in cytotoxicity.
Baumann RP, Shyam K, Penketh PG, Remack JS, Brent TP, Sartorelli AC. Baumann RP, et al. Among authors: brent tp. Cancer Chemother Pharmacol. 2004 Apr;53(4):288-95. doi: 10.1007/s00280-003-0739-0. Epub 2003 Dec 17. Cancer Chemother Pharmacol. 2004. PMID: 14685775
Heterogeneous methylation of the O(6)-methylguanine-DNA methyltransferase promoter in immortalized IMR90 cell lines.
Danam RP, Howell SR, Remack JS, Brent TP. Danam RP, et al. Among authors: brent tp. Int J Oncol. 2001 Jun;18(6):1187-93. doi: 10.3892/ijo.18.6.1187. Int J Oncol. 2001. PMID: 11351250
Antitumor activity of temozolomide combined with irinotecan is partly independent of O6-methylguanine-DNA methyltransferase and mismatch repair phenotypes in xenograft models.
Houghton PJ, Stewart CF, Cheshire PJ, Richmond LB, Kirstein MN, Poquette CA, Tan M, Friedman HS, Brent TP. Houghton PJ, et al. Among authors: brent tp. Clin Cancer Res. 2000 Oct;6(10):4110-8. Clin Cancer Res. 2000. PMID: 11051264 Free article.
Biochemical correlates of temozolomide sensitivity in pediatric solid tumor xenograft models.
Middlemas DS, Stewart CF, Kirstein MN, Poquette C, Friedman HS, Houghton PJ, Brent TP. Middlemas DS, et al. Among authors: brent tp. Clin Cancer Res. 2000 Mar;6(3):998-1007. Clin Cancer Res. 2000. PMID: 10741727 Free article.
Cytoplasmic sequestration of an O6-methylguanine-DNA methyltransferase enhancer binding protein in DNA repair-deficient human cells.
Chen FY, Harris LC, Remack JS, Brent TP. Chen FY, et al. Among authors: brent tp. Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4348-53. doi: 10.1073/pnas.94.9.4348. Proc Natl Acad Sci U S A. 1997. PMID: 9113992 Free PMC article.
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