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Identification of a dual δ OR antagonist/μ OR agonist as a potential therapeutic for diarrhea-predominant Irritable Bowel Syndrome (IBS-d).
Breslin HJ, Diamond CJ, Kavash RW, Cai C, Dyatkin AB, Miskowski TA, Zhang SP, Wade PR, Hornby PJ, He W. Breslin HJ, et al. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4869-72. doi: 10.1016/j.bmcl.2012.05.042. Epub 2012 May 24. Bioorg Med Chem Lett. 2012. PMID: 22695132
Antihypertensive dihydropyridines with 1,4,4-trisubstitution.
Kukla MJ, Breslin HJ, Gill A. Kukla MJ, et al. J Med Chem. 1990 Jan;33(1):223-8. doi: 10.1021/jm00163a037. J Med Chem. 1990. PMID: 2296021
Synthesis and anti-HIV activity of 1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one (TBO) derivatives. Truncated 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2( 1H)-on es (TIBO) analogues.
Breslin HJ, Kukla MJ, Kromis T, Cullis H, De Knaep F, Pauwels R, Andries K, De Clercq E, Janssen MA, Janssen PA. Breslin HJ, et al. Bioorg Med Chem. 1999 Nov;7(11):2427-36. doi: 10.1016/s0968-0896(99)00198-4. Bioorg Med Chem. 1999. PMID: 10632052
Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo-[4,5,1-jk][1,4]benzodiazepin- 2(1H)-one (TlBO) derivatives. 4.
Ho W, Kukla MJ, Breslin HJ, Ludovici DW, Grous PP, Diamond CJ, Miranda M, Rodgers JD, Ho CY, De Clercq E, et al. Ho W, et al. J Med Chem. 1995 Mar 3;38(5):794-802. doi: 10.1021/jm00005a006. J Med Chem. 1995. PMID: 7877144
Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo [4,5,1-jk][1,4]benzodiazepin-2(1H)-one (TIBO) derivatives. 3.
Breslin HJ, Kukla MJ, Ludovici DW, Mohrbacher R, Ho W, Miranda M, Rodgers JD, Hitchens TK, Leo G, Gauthier DA, et al. Breslin HJ, et al. J Med Chem. 1995 Mar 3;38(5):771-93. doi: 10.1021/jm00005a005. J Med Chem. 1995. PMID: 7877143
Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin- 2(1H)-one (TIBO) derivatives.
Kukla MJ, Breslin HJ, Pauwels R, Fedde CL, Miranda M, Scott MK, Sherrill RG, Raeymaekers A, Van Gelder J, Andries K, et al. Kukla MJ, et al. J Med Chem. 1991 Feb;34(2):746-51. doi: 10.1021/jm00106a040. J Med Chem. 1991. PMID: 1995896
Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-on e (TIBO) derivatives. 2.
Kukla MJ, Breslin HJ, Diamond CJ, Grous PP, Ho CY, Miranda M, Rodgers JD, Sherrill RG, De Clercq E, Pauwels R, et al. Kukla MJ, et al. J Med Chem. 1991 Nov;34(11):3187-97. doi: 10.1021/jm00115a007. J Med Chem. 1991. PMID: 1956037
Modulation of gastrointestinal function by MuDelta, a mixed µ opioid receptor agonist/ µ opioid receptor antagonist.
Wade PR, Palmer JM, McKenney S, Kenigs V, Chevalier K, Moore BA, Mabus JR, Saunders PR, Wallace NH, Schneider CR, Kimball ES, Breslin HJ, He W, Hornby PJ. Wade PR, et al. Among authors: breslin hj. Br J Pharmacol. 2012 Nov;167(5):1111-25. doi: 10.1111/j.1476-5381.2012.02068.x. Br J Pharmacol. 2012. PMID: 22671931 Free PMC article.
Design, synthesis, and anaplastic lymphoma kinase (ALK) inhibitory activity for a novel series of 2,4,8,22-tetraazatetracyclo[14.3.1.1³,⁷.1⁹,¹³]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaene macrocycles.
Breslin HJ, Lane BM, Ott GR, Ghose AK, Angeles TS, Albom MS, Cheng M, Wan W, Haltiwanger RC, Wells-Knecht KJ, Dorsey BD. Breslin HJ, et al. J Med Chem. 2012 Jan 12;55(1):449-64. doi: 10.1021/jm201333e. Epub 2011 Dec 15. J Med Chem. 2012. PMID: 22172029
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