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Rat prostaglandin EP3 receptor is highly promiscuous and is the sole prostanoid receptor family member that regulates INS-1 (832/3) cell glucose-stimulated insulin secretion.
Sandhu HK, Neuman JC, Schaid MD, Davis SE, Connors KM, Challa R, Guthery E, Fenske RJ, Patibandla C, Breyer RM, Kimple ME. Sandhu HK, et al. Among authors: breyer rm. Pharmacol Res Perspect. 2021 Apr;9(2):e00736. doi: 10.1002/prp2.736. Pharmacol Res Perspect. 2021. PMID: 33694300 Free PMC article.
Pharmacological blockade of the EP3 prostaglandin E2 receptor in the setting of type 2 diabetes enhances β-cell proliferation and identity and relieves oxidative damage.
Bosma KJ, Andrei SR, Katz LS, Smith AA, Dunn JC, Ricciardi VF, Ramirez MA, Baumel-Alterzon S, Pace WA, Carroll DT, Overway EM, Wolf EM, Kimple ME, Sheng Q, Scott DK, Breyer RM, Gannon M. Bosma KJ, et al. Among authors: breyer rm. Mol Metab. 2021 Dec;54:101347. doi: 10.1016/j.molmet.2021.101347. Epub 2021 Oct 6. Mol Metab. 2021. PMID: 34626853 Free PMC article.
The PGE2 EP3 Receptor Regulates Diet-Induced Adiposity in Male Mice.
Ceddia RP, Lee D, Maulis MF, Carboneau BA, Threadgill DW, Poffenberger G, Milne G, Boyd KL, Powers AC, McGuinness OP, Gannon M, Breyer RM. Ceddia RP, et al. Among authors: breyer rm. Endocrinology. 2016 Jan;157(1):220-32. doi: 10.1210/en.2015-1693. Epub 2015 Oct 20. Endocrinology. 2016. PMID: 26485614 Free PMC article.
134 results