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Purification and characterization of oxidoreductases-catalyzing carbonyl reduction of the tobacco-specific nitrosamine 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in human liver cytosol.
Atalla A, Breyer-Pfaff U, Maser E. Atalla A, et al. Among authors: breyer pfaff u. Xenobiotica. 2000 Aug;30(8):755-69. doi: 10.1080/00498250050119826. Xenobiotica. 2000. PMID: 11037109
Isolation and identification of hydroxylated maprotiline metabolites.
Breyer-Pfaff U, Kroeker M, Winkler T, Kriemler P. Breyer-Pfaff U, et al. Xenobiotica. 1985 Jan;15(1):57-66. doi: 10.3109/00498258509045335. Xenobiotica. 1985. PMID: 3984384
Stereoselective reversible ketone formation from 10-hydroxylated nortriptyline metabolites in human liver.
Breyer-Pfaff U, Nill K. Breyer-Pfaff U, et al. Xenobiotica. 1995 Dec;25(12):1311-25. doi: 10.3109/00498259509061920. Xenobiotica. 1995. PMID: 8719907
Quaternary N-glucuronides of 10-hydroxylated amitriptyline metabolites in human urine.
Breyer-Pfaff U, Becher B, Nusser E, Nill K, Baier-Weber B, Zaunbrecher D, Wachsmuth H, Prox A. Breyer-Pfaff U, et al. Xenobiotica. 1990 Jul;20(7):727-38. doi: 10.3109/00498259009046888. Xenobiotica. 1990. PMID: 2238706
Purification and characterization of akr1b10 from human liver: role in carbonyl reduction of xenobiotics.
Martin HJ, Breyer-Pfaff U, Wsol V, Venz S, Block S, Maser E. Martin HJ, et al. Among authors: breyer pfaff u. Drug Metab Dispos. 2006 Mar;34(3):464-70. doi: 10.1124/dmd.105.007971. Epub 2005 Dec 28. Drug Metab Dispos. 2006. PMID: 16381663
Enantioselectivity of carbonyl reduction of 4-methylnitrosamino-1-(3-pyridyl)-1-butanone by tissue fractions from human and rat and by enzymes isolated from human liver.
Breyer-Pfaff U, Martin HJ, Ernst M, Maser E. Breyer-Pfaff U, et al. Drug Metab Dispos. 2004 Sep;32(9):915-22. Drug Metab Dispos. 2004. PMID: 15319331
Conjugation of the enantiomers of ketotifen to four isomeric quaternary ammonium glucuronides in humans in vivo and in liver microsomes.
Mey U, Wachsmuth H, Breyer-Pfaff U. Mey U, et al. Drug Metab Dispos. 1999 Nov;27(11):1281-92. Drug Metab Dispos. 1999. PMID: 10534313
Carbonyl reduction of naltrexone and dolasetron by oxidoreductases isolated from human liver cytosol.
Breyer-Pfaff U, Nill K. Breyer-Pfaff U, et al. J Pharm Pharmacol. 2004 Dec;56(12):1601-6. doi: 10.1211/0022357045020. J Pharm Pharmacol. 2004. PMID: 15563768
Stereoselective high-affinity reduction of ketonic nortriptyline metabolites and of ketotifen by aldo-keto reductases from human liver.
Breyer-Pfaff U, Nill K. Breyer-Pfaff U, et al. Adv Exp Med Biol. 1999;463:473-80. doi: 10.1007/978-1-4615-4735-8_59. Adv Exp Med Biol. 1999. PMID: 10352721 No abstract available.
High-affinity stereoselective reduction of the enantiomers of ketotifen and of ketonic nortriptyline metabolites by aldo-keto reductases from human liver.
Breyer-Pfaff U, Nill K. Breyer-Pfaff U, et al. Biochem Pharmacol. 2000 Feb 1;59(3):249-60. doi: 10.1016/s0006-2952(99)00319-6. Biochem Pharmacol. 2000. PMID: 10609553
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