Brian J Lee AND Zha Shan - Search Results

Year	Number of Results
2014	1
2015	3
2016	1
2017	1
2018	3
2019	2
2020	7
2021	3
2022	1
2023	7
2024	4
2025	4
2026	2

1

PARG inhibition sequesters nuclear PAR-binding proteins, including XRCC1 and its partners, into nuclear condensates to elicit cytotoxicity.

Dumoulin I, Lee BJ, Zhang C, Lin X, Wang Y, Zha S. Dumoulin I, et al. Among authors: zha s, lee bj. bioRxiv [Preprint]. 2026 Mar 20:2026.03.18.712393. doi: 10.64898/2026.03.18.712393. bioRxiv. 2026. PMID: 41890038 Free PMC article. Preprint.

2

Visualization and quantification of rDNA instabilities in mammalian cells and mouse models.

Zhu X, Jiang W, Wu W, Lee BJ, Menolfi D, Tubbs A, Cupo OM, Malkovskiy E, Nester M, Wang XS, Sims PA, Lin CV, Symington L, Nussenzweig A, McStay B, Zha S. Zhu X, et al. Among authors: zha s, lee bj. Nucleic Acids Res. 2026 Jan 14;54(2):gkaf1523. doi: 10.1093/nar/gkaf1523. Nucleic Acids Res. 2026. PMID: 41533570 Free PMC article.

3

Primate-specific adaptation of Ku protects transcriptomic integrity by suppressing Alu-mediated alternative splicing.

Yu T, Yoon J, Zhu Y, Li A, Lee BJ, Moakley DF, Duan J, Deng Q, Hou F, Yan M, Gennarino VA, Zhang K, Chen L, Zha S, Zhang C. Yu T, et al. Among authors: zha s, lee bj. bioRxiv [Preprint]. 2025 Dec 18:2025.12.17.694518. doi: 10.64898/2025.12.17.694518. bioRxiv. 2025. PMID: 41446183 Free PMC article. Preprint.

4

Ku limits RNA-induced innate immunity to allow Alu expansion in primates.

Zhu Y, Li A, Maji S, Lee BJ, Korn SM, Gertie JA, Dorrity TJ, Wang J, Wang KJ, Pelletier A, Moakley DF, Kelly RD, Holmes AB, Rabadan R, Edgell DR, Schild-Poulter C, Modesti M, Steckelberg AL, Hendrickson EA, Chung H, Zhang C, Zha S. Zhu Y, et al. Among authors: zha s, lee bj. Nature. 2025 Jul;643(8071):562-571. doi: 10.1038/s41586-025-09104-w. Epub 2025 May 15. Nature. 2025. PMID: 40373806 Free PMC article.

5

Ku suppresses RNA-mediated innate immune responses in human cells to accommodate primate-specific Alu expansion.

Zhu Y, Li A, Maji S, Lee BJ, Korn SM, Gertie JA, Dorrity TJ, Wang J, Wang KJ, Pelletier A, Moakley DF, Kelly RD, Holmes AB, Rabadan R, Edgell DR, Schild Poulter C, Modesti M, Steckelberg AL, Hendrickson EA, Chung H, Zhang C, Zha S. Zhu Y, et al. Among authors: zha s, lee bj. bioRxiv [Preprint]. 2025 Feb 1:2025.01.31.633084. doi: 10.1101/2025.01.31.633084. bioRxiv. 2025. PMID: 39975384 Free PMC article. Preprint.

6

XRCC1 mediates PARP1- and PAR-dependent recruitment of PARP2 to DNA damage sites.

Lin X, Leung KSK, Wolfe KF, Call N, Bhandari SK, Huang X, Lee BJ, Tomkinson AE, Zha S. Lin X, et al. Among authors: zha s, lee bj. Nucleic Acids Res. 2025 Feb 8;53(4):gkaf086. doi: 10.1093/nar/gkaf086. Nucleic Acids Res. 2025. PMID: 39970298 Free PMC article.

7

Inactive Parp2 causes Tp53-dependent lethal anemia by blocking replication-associated nick ligation in erythroblasts.

Lin X, Gupta D, Vaitsiankova A, Bhandari SK, Leung KSK, Menolfi D, Lee BJ, Russell HR, Gershik S, Huang X, Gu W, McKinnon PJ, Dantzer F, Rothenberg E, Tomkinson AE, Zha S. Lin X, et al. Among authors: zha s, lee bj. Mol Cell. 2024 Oct 17;84(20):3916-3931.e7. doi: 10.1016/j.molcel.2024.09.020. Epub 2024 Oct 8. Mol Cell. 2024. PMID: 39383878 Free PMC article.

8

The KU70-SAP domain has an overlapping function with DNA-PKcs in limiting the lateral movement of KU along DNA.

Zhu Y, Lee BJ, Fujii S, Jonchhe S, Zhang H, Li A, Wang KJ, Rothenberg E, Modesti M, Zha S. Zhu Y, et al. Among authors: zha s, lee bj. bioRxiv [Preprint]. 2024 Aug 27:2024.08.26.609806. doi: 10.1101/2024.08.26.609806. bioRxiv. 2024. PMID: 39253422 Free PMC article. Preprint.

9

XRCC1 mediates PARP1- and PAR-dependent recruitment of PARP2 to DNA damage sites.

Lin X, Leung KSK, Wolfe KF, Lee BJ, Zha S. Lin X, et al. Among authors: zha s, lee bj. bioRxiv [Preprint]. 2024 May 17:2024.05.14.594230. doi: 10.1101/2024.05.14.594230. bioRxiv. 2024. Update in: Nucleic Acids Res. 2025 Feb 08;53(4):gkaf086. doi: 10.1093/nar/gkaf086. PMID: 38798615 Free PMC article. Updated. Preprint.

10

Inactive Parp2 causes Tp53-dependent lethal anemia by blocking replication-associated nick ligation in erythroblasts.

Lin X, Gupta D, Vaitsiankova A, Bhandari SK, Leung KSK, Menolfi D, Lee BJ, Russell HR, Gershik S, Gu W, McKinnon PJ, Dantzer F, Rothenberg E, Tomkinson AE, Zha S. Lin X, et al. Among authors: zha s, lee bj. bioRxiv [Preprint]. 2024 Mar 14:2024.03.12.584665. doi: 10.1101/2024.03.12.584665. bioRxiv. 2024. Update in: Mol Cell. 2024 Oct 17;84(20):3916-3931.e7. doi: 10.1016/j.molcel.2024.09.020. PMID: 38559022 Free PMC article. Updated. Preprint.

11

A noncanonical IRAK4-IRAK1 pathway counters DNA damage-induced apoptosis independently of TLR/IL-1R signaling.

Li Y, Shah RB, Sarti S, Belcher AL, Lee BJ, Gorbatenko A, Nemati F, Yu H, Stanley Z, Rahman M, Shao Z, Silva JM, Zha S, Sidi S. Li Y, et al. Among authors: zha s, lee bj. Sci Signal. 2023 Dec 19;16(816):eadh3449. doi: 10.1126/scisignal.adh3449. Epub 2023 Dec 19. Sci Signal. 2023. PMID: 38113335 Free PMC article.

12

Inactive PARP1 causes embryonic lethality and genome instability in a dominant-negative manner.

Shao Z, Lee BJ, Zhang H, Lin X, Li C, Jiang W, Chirathivat N, Gershik S, Shen MM, Baer R, Zha S. Shao Z, et al. Among authors: zha s, lee bj. Proc Natl Acad Sci U S A. 2023 Aug;120(31):e2301972120. doi: 10.1073/pnas.2301972120. Epub 2023 Jul 24. Proc Natl Acad Sci U S A. 2023. PMID: 37487079 Free PMC article.

13

ATR kinase supports normal proliferation in the early S phase by preventing replication resource exhaustion.

Menolfi D, Lee BJ, Zhang H, Jiang W, Bowen NE, Wang Y, Zhao J, Holmes A, Gershik S, Rabadan R, Kim B, Zha S. Menolfi D, et al. Among authors: zha s, lee bj. Nat Commun. 2023 Jun 19;14(1):3618. doi: 10.1038/s41467-023-39332-5. Nat Commun. 2023. PMID: 37336885 Free PMC article.

14

Oncogenic IDH mutations increase heterochromatin-related replication stress without impacting homologous recombination.

Schvartzman JM, Forsyth G, Walch H, Chatila W, Taglialatela A, Lee BJ, Zhu X, Gershik S, Cimino FV, Santella A, Menghrajani K, Ciccia A, Koche R, Sánchez-Vega F, Zha S, Thompson CB. Schvartzman JM, et al. Among authors: zha s, lee bj. Mol Cell. 2023 Jul 6;83(13):2347-2356.e8. doi: 10.1016/j.molcel.2023.05.026. Epub 2023 Jun 12. Mol Cell. 2023. PMID: 37311462 Free PMC article.

15

Phosphorylation of DNA-PKcs at the S2056 cluster ensures efficient and productive lymphocyte development in XLF-deficient mice.

Zhu Y, Jiang W, Lee BJ, Li A, Gershik S, Zha S. Zhu Y, et al. Among authors: zha s, lee bj. Proc Natl Acad Sci U S A. 2023 Jun 20;120(25):e2221894120. doi: 10.1073/pnas.2221894120. Epub 2023 Jun 12. Proc Natl Acad Sci U S A. 2023. PMID: 37307443 Free PMC article.

16

ATR kinase supports normal proliferation in the early S phase by preventing replication resource exhaustion.

Menolfi D, Lee BJ, Zhang H, Jiang W, Bowen NE, Wang Y, Zhao J, Holmes A, Gershik S, Rabadan R, Kim B, Zha S. Menolfi D, et al. Among authors: zha s, lee bj. bioRxiv [Preprint]. 2023 May 27:2023.05.26.542515. doi: 10.1101/2023.05.26.542515. bioRxiv. 2023. Update in: Nat Commun. 2023 Jun 19;14(1):3618. doi: 10.1038/s41467-023-39332-5. PMID: 37292881 Free PMC article. Updated. Preprint.

17

A Non-Canonical IRAK Signaling Pathway Triggered by DNA Damage.

Li Y, Shah RB, Sarti S, Belcher AL, Lee BJ, Gorbatenko A, Nemati F, Yu I, Stanley Z, Shao Z, Silva JM, Zha S, Sidi S. Li Y, et al. Among authors: zha s, lee bj. bioRxiv [Preprint]. 2023 Feb 8:2023.02.08.527716. doi: 10.1101/2023.02.08.527716. bioRxiv. 2023. PMID: 36798275 Free PMC article. Preprint.

18

PARP inhibitors trap PARP2 and alter the mode of recruitment of PARP2 at DNA damage sites.

Lin X, Jiang W, Rudolph J, Lee BJ, Luger K, Zha S. Lin X, et al. Among authors: zha s, lee bj. Nucleic Acids Res. 2022 Apr 22;50(7):3958-3973. doi: 10.1093/nar/gkac188. Nucleic Acids Res. 2022. PMID: 35349716 Free PMC article.

19

DNA damage-induced phosphorylation of CtIP at a conserved ATM/ATR site T855 promotes lymphomagenesis in mice.

Wang XS, Menolfi D, Wu-Baer F, Fangazio M, Meyer SN, Shao Z, Wang Y, Zhu Y, Lee BJ, Estes VM, Cupo OM, Gautier J, Pasqualucci L, Dalla-Favera R, Baer R, Zha S. Wang XS, et al. Among authors: zha s, lee bj. Proc Natl Acad Sci U S A. 2021 Sep 21;118(38):e2105440118. doi: 10.1073/pnas.2105440118. Proc Natl Acad Sci U S A. 2021. PMID: 34521752 Free PMC article.

20

FATC Domain Deletion Compromises ATM Protein Stability, Blocks Lymphocyte Development, and Promotes Lymphomagenesis.

Milanovic M, Shao Z, Estes VM, Wang XS, Menolfi D, Lin X, Lee BJ, Xu J, Cupo OM, Wang D, Zha S. Milanovic M, et al. Among authors: zha s, lee bj. J Immunol. 2021 Mar 15;206(6):1228-1239. doi: 10.4049/jimmunol.2000967. Epub 2021 Feb 3. J Immunol. 2021. PMID: 33536256 Free PMC article.

21

The Cancer-Associated ATM R3008H Mutation Reveals the Link between ATM Activation and Its Exchange.

Milanovic M, Sprinzen L, Menolfi D, Lee JH, Yamamoto K, Li Y, Lee BJ, Xu J, Estes VM, Wang D, Mckinnon PJ, Paull TT, Zha S. Milanovic M, et al. Among authors: zha s, lee bj. Cancer Res. 2021 Jan 15;81(2):426-437. doi: 10.1158/0008-5472.CAN-20-2447. Epub 2020 Nov 25. Cancer Res. 2021. PMID: 33239428 Free PMC article.

22

CtIP-mediated DNA resection is dispensable for IgH class switch recombination by alternative end-joining.

Wang XS, Zhao J, Wu-Baer F, Shao Z, Lee BJ, Cupo OM, Rabadan R, Gautier J, Baer R, Zha S. Wang XS, et al. Among authors: zha s, lee bj. Proc Natl Acad Sci U S A. 2020 Oct 13;117(41):25700-25711. doi: 10.1073/pnas.2010972117. Epub 2020 Sep 28. Proc Natl Acad Sci U S A. 2020. PMID: 32989150 Free PMC article.

23

Clinical PARP inhibitors do not abrogate PARP1 exchange at DNA damage sites in vivo.

Shao Z, Lee BJ, Rouleau-Turcotte É, Langelier MF, Lin X, Estes VM, Pascal JM, Zha S. Shao Z, et al. Among authors: zha s, lee bj. Nucleic Acids Res. 2020 Sep 25;48(17):9694-9709. doi: 10.1093/nar/gkaa718. Nucleic Acids Res. 2020. PMID: 32890402 Free PMC article.

24

DNA-PKcs phosphorylation at the T2609 cluster alters the repair pathway choice during immunoglobulin class switch recombination.

Crowe JL, Wang XS, Shao Z, Lee BJ, Estes VM, Zha S. Crowe JL, et al. Among authors: zha s, lee bj. Proc Natl Acad Sci U S A. 2020 Sep 15;117(37):22953-22961. doi: 10.1073/pnas.2007455117. Epub 2020 Aug 31. Proc Natl Acad Sci U S A. 2020. PMID: 32868446 Free PMC article.

25

The recent advances in non-homologous end-joining through the lens of lymphocyte development.

Wang XS, Lee BJ, Zha S. Wang XS, et al. Among authors: zha s, lee bj. DNA Repair (Amst). 2020 Oct;94:102874. doi: 10.1016/j.dnarep.2020.102874. Epub 2020 Jun 25. DNA Repair (Amst). 2020. PMID: 32623318 Free PMC article. Review.

26

ERCC6L2 promotes DNA orientation-specific recombination in mammalian cells.

Liu X, Liu T, Shang Y, Dai P, Zhang W, Lee BJ, Huang M, Yang D, Wu Q, Liu LD, Zheng X, Zhou BO, Dong J, Yeap LS, Hu J, Xiao T, Zha S, Casellas R, Liu XS, Meng FL. Liu X, et al. Among authors: zha s, lee bj. Cell Res. 2020 Sep;30(9):732-744. doi: 10.1038/s41422-020-0328-3. Epub 2020 Apr 30. Cell Res. 2020. PMID: 32355287 Free PMC article.

27

DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis.

Shao Z, Flynn RA, Crowe JL, Zhu Y, Liang J, Jiang W, Aryan F, Aoude P, Bertozzi CR, Estes VM, Lee BJ, Bhagat G, Zha S, Calo E. Shao Z, et al. Among authors: zha s, lee bj. Nature. 2020 Mar;579(7798):291-296. doi: 10.1038/s41586-020-2041-2. Epub 2020 Feb 26. Nature. 2020. PMID: 32103174 Free PMC article.

28

Phosphorylation at S2053 in Murine (S2056 in Human) DNA-PKcs Is Dispensable for Lymphocyte Development and Class Switch Recombination.

Jiang W, Estes VM, Wang XS, Shao Z, Lee BJ, Lin X, Crowe JL, Zha S. Jiang W, et al. Among authors: zha s, lee bj. J Immunol. 2019 Jul 1;203(1):178-187. doi: 10.4049/jimmunol.1801657. Epub 2019 May 17. J Immunol. 2019. PMID: 31101667 Free PMC article.

29

CtIP is essential for early B cell proliferation and development in mice.

Liu X, Wang XS, Lee BJ, Wu-Baer FK, Lin X, Shao Z, Estes VM, Gautier J, Baer R, Zha S. Liu X, et al. Among authors: zha s, lee bj. J Exp Med. 2019 Jul 1;216(7):1648-1663. doi: 10.1084/jem.20181139. Epub 2019 May 16. J Exp Med. 2019. PMID: 31097467 Free PMC article.

30

Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA.

Menolfi D, Jiang W, Lee BJ, Moiseeva T, Shao Z, Estes V, Frattini MG, Bakkenist CJ, Zha S. Menolfi D, et al. Among authors: zha s, lee bj. Nat Commun. 2018 Dec 17;9(1):5351. doi: 10.1038/s41467-018-07798-3. Nat Commun. 2018. PMID: 30559436 Free PMC article.

31

Kinase-dependent structural role of DNA-PKcs during immunoglobulin class switch recombination.

Crowe JL, Shao Z, Wang XS, Wei PC, Jiang W, Lee BJ, Estes VM, Alt FW, Zha S. Crowe JL, et al. Among authors: zha s, lee bj. Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):8615-8620. doi: 10.1073/pnas.1808490115. Epub 2018 Aug 2. Proc Natl Acad Sci U S A. 2018. PMID: 30072430 Free PMC article.

32

MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining.

Hung PJ, Johnson B, Chen BR, Byrum AK, Bredemeyer AL, Yewdell WT, Johnson TE, Lee BJ, Deivasigamani S, Hindi I, Amatya P, Gross ML, Paull TT, Pisapia DJ, Chaudhuri J, Petrini JJH, Mosammaparast N, Amarasinghe GK, Zha S, Tyler JK, Sleckman BP. Hung PJ, et al. Among authors: zha s, lee bj. Mol Cell. 2018 Jul 19;71(2):332-342.e8. doi: 10.1016/j.molcel.2018.06.018. Epub 2018 Jul 12. Mol Cell. 2018. PMID: 30017584 Free PMC article.

33

PAXX promotes KU accumulation at DNA breaks and is essential for end-joining in XLF-deficient mice.

Liu X, Shao Z, Jiang W, Lee BJ, Zha S. Liu X, et al. Among authors: zha s, lee bj. Nat Commun. 2017 Jan 4;8:13816. doi: 10.1038/ncomms13816. Nat Commun. 2017. PMID: 28051062 Free PMC article.

34

Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitors.

Yamamoto K, Wang J, Sprinzen L, Xu J, Haddock CJ, Li C, Lee BJ, Loredan DG, Jiang W, Vindigni A, Wang D, Rabadan R, Zha S. Yamamoto K, et al. Among authors: zha s, lee bj. Elife. 2016 Jun 15;5:e14709. doi: 10.7554/eLife.14709. Elife. 2016. PMID: 27304073 Free PMC article.

35

Haploinsufficiency of Bcl11b suppresses the progression of ATM-deficient T cell lymphomas.

Pinkney KA, Jiang W, Lee BJ, Loredan DG, Li C, Bhagat G, Zha S. Pinkney KA, et al. Among authors: zha s, lee bj. J Hematol Oncol. 2015 Jul 30;8:94. doi: 10.1186/s13045-015-0191-8. J Hematol Oncol. 2015. PMID: 26219558 Free PMC article.

36

Differential phosphorylation of DNA-PKcs regulates the interplay between end-processing and end-ligation during nonhomologous end-joining.

Jiang W, Crowe JL, Liu X, Nakajima S, Wang Y, Li C, Lee BJ, Dubois RL, Liu C, Yu X, Lan L, Zha S. Jiang W, et al. Among authors: zha s, lee bj. Mol Cell. 2015 Apr 2;58(1):172-85. doi: 10.1016/j.molcel.2015.02.024. Epub 2015 Mar 26. Mol Cell. 2015. PMID: 25818648 Free PMC article.

37

Aberrant TCRδ rearrangement underlies the T-cell lymphocytopenia and t(12;14) translocation associated with ATM deficiency.

Jiang W, Lee BJ, Li C, Dubois RL, Gostissa M, Alt FW, Zha S. Jiang W, et al. Among authors: zha s, lee bj. Blood. 2015 Apr 23;125(17):2665-8. doi: 10.1182/blood-2015-01-622621. Epub 2015 Feb 26. Blood. 2015. PMID: 25721125 Free PMC article.

38

Hematopoietic stem cell dysfunction underlies the progressive lymphocytopenia in XLF/Cernunnos deficiency.

Avagyan S, Churchill M, Yamamoto K, Crowe JL, Li C, Lee BJ, Zheng T, Mukherjee S, Zha S. Avagyan S, et al. Among authors: zha s, lee bj. Blood. 2014 Sep 4;124(10):1622-5. doi: 10.1182/blood-2014-05-574863. Epub 2014 Jul 29. Blood. 2014. PMID: 25075129 Free PMC article.

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