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Page 1
Valoctocogene Roxaparvovec Gene Therapy for Hemophilia A.
Ozelo MC, Mahlangu J, Pasi KJ, Giermasz A, Leavitt AD, Laffan M, Symington E, Quon DV, Wang JD, Peerlinck K, Pipe SW, Madan B, Key NS, Pierce GF, O'Mahony B, Kaczmarek R, Henshaw J, Lawal A, Jayaram K, Huang M, Yang X, Wong WY, Kim B; GENEr8-1 Trial Group. Ozelo MC, et al. Among authors: o mahony b. N Engl J Med. 2022 Mar 17;386(11):1013-1025. doi: 10.1056/NEJMoa2113708. N Engl J Med. 2022. PMID: 35294811 Clinical Trial.
The efficacy and safety of the therapy were previously evaluated in men with severe hemophilia A in a phase 1-2 dose-escalation study. METHODS: We conducted an open-label, single-group, multicenter, phase 3 study to evaluate the efficacy and safety of valoctocogene roxapar …
The efficacy and safety of the therapy were previously evaluated in men with severe hemophilia A in a phase 1-2 dose-escalation study …
Evaluation of the sexual health in people living with hemophilia.
Germini F, Chai-Adisaksopha C, Pete D, Curtis R, Frick N, Nichol MB, Noone D, O'Mahony B, Page D, Stonebraker JS, Thabane L, Crowther MA, Skinner MW, Iorio A. Germini F, et al. Among authors: o mahony b. Haemophilia. 2021 Nov;27(6):993-1001. doi: 10.1111/hae.14410. Epub 2021 Sep 19. Haemophilia. 2021. PMID: 34538001
BACKGROUND: Knowledge about sexual health, difficulty with sexual activity and intimacy (sexual difficulty), in people with hemophilia is little understood. OBJECTIVES: The objectives were to determine the prevalence of sexual difficulty in people living with hemophilia
BACKGROUND: Knowledge about sexual health, difficulty with sexual activity and intimacy (sexual difficulty), in people with hemophilia
Eliminating Panglossian thinking in development of AAV therapeutics.
Kaczmarek R, Pierce GF, Noone D, O'Mahony B, Page D, Skinner MW. Kaczmarek R, et al. Among authors: o mahony b. Mol Ther. 2021 Dec 1;29(12):3325-3327. doi: 10.1016/j.ymthe.2021.10.025. Epub 2021 Nov 10. Mol Ther. 2021. PMID: 34758292 No abstract available.
Achieving the unimaginable: Health equity in haemophilia.
Skinner MW, Nugent D, Wilton P, O'Mahony B, Dolan G, O'Hara J, Berntorp E. Skinner MW, et al. Among authors: o mahony b. Haemophilia. 2020 Jan;26(1):17-24. doi: 10.1111/hae.13862. Epub 2019 Nov 13. Haemophilia. 2020. PMID: 31724316 Free PMC article. Review.
Historically, treatment based on the availability of clotting factor replacement has resulted in an arcane guideline for the correction of factor deficiencies in people with haemophilia (PwH). While all other disease entities seek to restore function to a normal level, PwH …
Historically, treatment based on the availability of clotting factor replacement has resulted in an arcane guideline for the correction of f …
Evidence of a disability paradox in patient-reported outcomes in haemophilia.
O'Hara J, Martin AP, Nugent D, Witkop M, Buckner TW, Skinner MW, O'Mahony B, Mulhern B, Morgan G, Li N, Sawyer EK. O'Hara J, et al. Among authors: o mahony b. Haemophilia. 2021 Mar;27(2):245-252. doi: 10.1111/hae.14278. Epub 2021 Feb 17. Haemophilia. 2021. PMID: 33595148 Free PMC article.
RESULTS: After removing respondents with response inconsistencies, 1327/2138 (62%) participants remained (177/283 haemophilia; 1150/1900 general population). Patients with haemophilia indicated higher preference value for 99% of EQ-5D-5L health states compared to th …
RESULTS: After removing respondents with response inconsistencies, 1327/2138 (62%) participants remained (177/283 haemophilia; 1150/1 …
Patient-relevant health outcomes for hemophilia care: Development of an international standard outcomes set.
van Balen EC, O'Mahony B, Cnossen MH, Dolan G, Blanchette VS, Fischer K, Gue D, O'Hara J, Iorio A, Jackson S, Konkle BA, Nugent DJ, Coffin D, Skinner MW, Smit C, Srivastava A, van Eenennaam F, van der Bom JG, Gouw SC. van Balen EC, et al. Among authors: o mahony b. Res Pract Thromb Haemost. 2021 Mar 6;5(4):e12488. doi: 10.1002/rth2.12488. eCollection 2021 May. Res Pract Thromb Haemost. 2021. PMID: 34027286 Free PMC article.
BACKGROUND: Patient-relevant health outcomes for persons with hemophilia should be identified and prioritized to optimize and individualize care for persons with hemophilia. Therefore, an international group of persons with hemophilia and multidisciplinary he …
BACKGROUND: Patient-relevant health outcomes for persons with hemophilia should be identified and prioritized to optimize and individ …
Haemophilia care in Europe: Past progress and future promise.
O'Mahony B. O'Mahony B. Haemophilia. 2020 Sep;26(5):752-758. doi: 10.1111/hae.14097. Epub 2020 Aug 4. Haemophilia. 2020. PMID: 32749007 Review.
Haemophilia care has experienced unprecedented advances over the past 50 years, with the promise of a functional 'cure' being within reach in the not so distant future. ...The future is bright, but only through active participation across the haemophilia community w
Haemophilia care has experienced unprecedented advances over the past 50 years, with the promise of a functional 'cure' being within
World Federation of Hemophilia Gene Therapy Registry.
Konkle BA, Coffin D, Pierce GF, Clark C, George L, Iorio A, Mahlangu J, Naccache M, O'Mahony B, Peyvandi F, Pipe S, Quartel A, Sawyer EK, Skinner MW, Tortella B, Watson C, Winburn I; Members of the WFH Gene Therapy Registery Steering Committee. Konkle BA, et al. Among authors: o mahony b. Haemophilia. 2020 Jul;26(4):563-564. doi: 10.1111/hae.14015. Epub 2020 May 27. Haemophilia. 2020. PMID: 32462720 Free PMC article. No abstract available.
Improving haemophilia patient care through sharing best practice.
de Moerloose P, Arnberg D, O'Mahony B, Colvin B. de Moerloose P, et al. Among authors: o mahony b. Eur J Haematol. 2015 Oct;95 Suppl 79:1-8. doi: 10.1111/ejh.12630. Eur J Haematol. 2015. PMID: 26338268
At the 2014 Annual Congress of the European Haemophilia Consortium (EHC) held in Belfast, Northern Ireland, Pfizer initiated and funded a satellite symposium entitled: 'Improving Patient Care Through Sharing Best Practice'. ...Finally, Brian O'Mahony reflected on the centr …
At the 2014 Annual Congress of the European Haemophilia Consortium (EHC) held in Belfast, Northern Ireland, Pfizer initiated and fund …
Non-severe haemophilia: Is it benign? - Insights from the PROBE study.
Chai-Adisaksopha C, Noone D, Curtis R, Frick N, Nichol MB, Germini F, O'Mahony B, Page D, Stonebraker JS, Skinner MW, Iorio A. Chai-Adisaksopha C, et al. Among authors: o mahony b. Haemophilia. 2021 Jan;27 Suppl 1:17-24. doi: 10.1111/hae.14105. Epub 2020 Sep 1. Haemophilia. 2021. PMID: 32870546
INTRODUCTION: There are limited data on the impact of haemophilia on health status and health-related quality of life (HRQL) in people with non-severe (mild and moderate) haemophilia. ...CONCLUSION: People affected by mild or moderate haemophilia report a sig …
INTRODUCTION: There are limited data on the impact of haemophilia on health status and health-related quality of life (HRQL) in peopl …
40 results