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The Bunyamwera virus nonstructural protein NSs inhibits viral RNA synthesis in a minireplicon system.
Weber F, Dunn EF, Bridgen A, Elliott RM. Weber F, et al. Among authors: bridgen a. Virology. 2001 Mar 1;281(1):67-74. doi: 10.1006/viro.2000.0774. Virology. 2001. PMID: 11222097
Expression of N, the viral polymerase protein (L), and a minireplicon containing a reporter gene was sufficient to reconstitute functional virus nucleocapsids. Coexpression of NSs, however, led to a dose-dependent decrease in reporter activity without affecti …
Expression of N, the viral polymerase protein (L), and a minireplicon containing a reporter gene was sufficient to reconstitut …
Dugbe virus ovarian tumour domain interferes with ubiquitin/ISG15-regulated innate immune cell signalling.
Bakshi S, Holzer B, Bridgen A, McMullan G, Quinn DG, Baron MD. Bakshi S, et al. Among authors: bridgen a. J Gen Virol. 2013 Feb;94(Pt 2):298-307. doi: 10.1099/vir.0.048322-0. Epub 2012 Nov 7. J Gen Virol. 2013. PMID: 23136361 Free PMC article.
Bunyamwera virus nonstructural protein NSs counteracts interferon regulatory factor 3-mediated induction of early cell death.
Kohl A, Clayton RF, Weber F, Bridgen A, Randall RE, Elliott RM. Kohl A, et al. Among authors: bridgen a. J Virol. 2003 Jul;77(14):7999-8008. doi: 10.1128/jvi.77.14.7999-8008.2003. J Virol. 2003. PMID: 12829839 Free PMC article.
Activation of PKR by Bunyamwera virus is independent of the viral interferon antagonist NSs.
Streitenfeld H, Boyd A, Fazakerley JK, Bridgen A, Elliott RM, Weber F. Streitenfeld H, et al. Among authors: bridgen a. J Virol. 2003 May;77(9):5507-11. doi: 10.1128/jvi.77.9.5507-5511.2003. J Virol. 2003. PMID: 12692253 Free PMC article.
Bunyamwera bunyavirus nonstructural protein NSs counteracts the induction of alpha/beta interferon.
Weber F, Bridgen A, Fazakerley JK, Streitenfeld H, Kessler N, Randall RE, Elliott RM. Weber F, et al. Among authors: bridgen a. J Virol. 2002 Aug;76(16):7949-55. doi: 10.1128/jvi.76.16.7949-7955.2002. J Virol. 2002. PMID: 12133999 Free PMC article.
By using reverse genetics, we previously produced a recombinant virus lacking the nonstructural protein NSs (BUNdelNSs) and showed that NSs is a nonessential gene product that contributes to viral pathogenesis. Here we demonstrate that BUNdelNSs is a strong i …
By using reverse genetics, we previously produced a recombinant virus lacking the nonstructural protein NSs (BUNdelNSs) and showed th …
Dugbe nairovirus S segment: correction of published sequence and comparison of five isolates.
Bridgen A, Dalrymple DA, Elliott RM. Bridgen A, et al. Virology. 2002 Mar 15;294(2):364-71. doi: 10.1006/viro.2001.1324. Virology. 2002. PMID: 12009878
The sequence of the S (small) RNA segment of the ArD 44313 isolate of Dugbe nairovirus (DUG) has been redetermined, and a number of apparent errors in the previously reported sequence (V. ...Ward, A. C. Marriott, A. A. El-Ghorr, and P. A. Nuttal …
The sequence of the S (small) RNA segment of the ArD 44313 isolate of Dugbe nairovirus (DUG) has been redetermined, and a number of a …
Effects of a point mutation in the 3' end of the S genome segment of naturally occurring and engineered Bunyamwera viruses.
Kohl A, Bridgen A, Dunn E, Barr JN, Elliott RM. Kohl A, et al. Among authors: bridgen a. J Gen Virol. 2003 Apr;84(Pt 4):789-793. doi: 10.1099/vir.0.18963-0. J Gen Virol. 2003. PMID: 12655079
The smallest segment, S, encodes the N protein and a nonstructural protein called NSs. We recently described a mutant virus (BUNdelNSs) that does not express NSs but overexpresses N and grows to lower titres than wild-type (wt) BUN. Here we report a BUNdelNSs …
The smallest segment, S, encodes the N protein and a nonstructural protein called NSs. We recently described a mutant virus (B …
Inhibition of Dugbe nairovirus replication by human MxA protein.
Bridgen A, Dalrymple DA, Weber F, Elliott RM. Bridgen A, et al. Virus Res. 2004 Jan;99(1):47-50. doi: 10.1016/j.virusres.2003.10.002. Virus Res. 2004. PMID: 14687945
Rescue of a segmented negative-strand RNA virus entirely from cloned complementary DNAs.
Bridgen A, Elliott RM. Bridgen A, et al. Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15400-4. doi: 10.1073/pnas.93.26.15400. Proc Natl Acad Sci U S A. 1996. PMID: 8986823 Free PMC article.
We provide the first report, to our knowledge, of a helper-independent system for rescuing a segmented, negative-strand RNA genome virus entirely from cloned cDNAs. ...
We provide the first report, to our knowledge, of a helper-independent system for rescuing a segmented, negative-strand RNA ge …
Bunyamwera bunyavirus nonstructural protein NSs is a nonessential gene product that contributes to viral pathogenesis.
Bridgen A, Weber F, Fazakerley JK, Elliott RM. Bridgen A, et al. Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):664-9. doi: 10.1073/pnas.98.2.664. Proc Natl Acad Sci U S A. 2001. PMID: 11209062 Free PMC article.
Bunyamwera virus (family Bunyaviridae, genus Bunyavirus) contains a tripartite negative-sense RNA genome. The smallest RNA segment, S, encodes the nucleocapsid protein N and a nonstructural protein, NSs, in overlapping reading frames. ...When inoculated by the intra …
Bunyamwera virus (family Bunyaviridae, genus Bunyavirus) contains a tripartite negative-sense RNA genome. The smallest RNA segment, S …
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