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Metabolism of amprenavir in liver microsomes: role of CYP3A4 inhibition for drug interactions.
J Pharm Sci. 1998 Jul;87(7):803-7. doi: 10.1021/js980029p.
J Pharm Sci. 1998.
PMID: 9649346
Altering metabolic profiles of drugs by precision deuteration: reducing mechanism-based inhibition of CYP2D6 by paroxetine.
Uttamsingh V, Gallegos R, Liu JF, Harbeson SL, Bridson GW, Cheng C, Wells DS, Graham PB, Zelle R, Tung R.
Uttamsingh V, et al. Among authors: bridson gw.
J Pharmacol Exp Ther. 2015 Jul;354(1):43-54. doi: 10.1124/jpet.115.223768. Epub 2015 May 5.
J Pharmacol Exp Ther. 2015.
PMID: 25943764
Clinical Trial.
Item in Clipboard
Altering Metabolic Profiles of Drugs by Precision Deuteration 2: Discovery of a Deuterated Analog of Ivacaftor with Differentiated Pharmacokinetics for Clinical Development.
Harbeson SL, Morgan AJ, Liu JF, Aslanian AM, Nguyen S, Bridson GW, Brummel CL, Wu L, Tung RD, Pilja L, Braman V, Uttamsingh V.
Harbeson SL, et al. Among authors: bridson gw.
J Pharmacol Exp Ther. 2017 Aug;362(2):359-367. doi: 10.1124/jpet.117.241497. Epub 2017 Jun 13.
J Pharmacol Exp Ther. 2017.
PMID: 28611092
Clinical Trial.
Item in Clipboard
Identification and structural elucidation of in vitro metabolites of atazanavir by HPLC and tandem mass spectrometry.
Cheng C, Gallegos R, Bridson G, Wu L, Harbeson S, Zelle R, Tung R.
Cheng C, et al.
J Mass Spectrom. 2013 Jun;48(6):640-50. doi: 10.1002/jms.3201.
J Mass Spectrom. 2013.
PMID: 23722954
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Dual Therapeutic Effects of C-10068, a Dextromethorphan Derivative, Against Post-Traumatic Nonconvulsive Seizures and Neuroinflammation in a Rat Model of Penetrating Ballistic-Like Brain Injury.
Lu XC, Shear DA, Graham PB, Bridson GW, Uttamsingh V, Chen Z, Leung LY, Tortella FC.
Lu XC, et al. Among authors: bridson gw.
J Neurotrauma. 2015 Oct 15;32(20):1621-32. doi: 10.1089/neu.2014.3766. Epub 2015 Jun 11.
J Neurotrauma. 2015.
PMID: 25794265
Free PMC article.
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Quantitative analyses of CTP-499 and five major metabolites by core-structure analysis.
Tang X, Bridson G, Ke J, Wu L, Erol H, Graham P, Lin CH, Braman V, Zhao H, Liu JF, Lin ZJ, Cheng C.
Tang X, et al.
J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Jul 15;963:1-9. doi: 10.1016/j.jchromb.2014.05.043. Epub 2014 May 28.
J Chromatogr B Analyt Technol Biomed Life Sci. 2014.
PMID: 24927417
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In vitro-in vivo correlation on delivery of drug candidates to articular cartilage.
Wang Q, Glasson S, Raut U, Emerson J, Blanchet T, Bridson G, Sheldon R, Mollova N, Morris E, Xu X, Patel VS.
Wang Q, et al.
Pharm Res. 2008 Jul;25(7):1641-6. doi: 10.1007/s11095-008-9557-8. Epub 2008 Mar 7.
Pharm Res. 2008.
PMID: 18324355
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