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Yeast mitochondrial phosphate transport protein expressed in Escherichia coli. Site-directed mutations at threonine-43 and at a similar location in the second tandem repeat (isoleucine-141).
Wohlrab H, Briggs C. Wohlrab H, et al. Biochemistry. 1994 Aug 16;33(32):9371-5. doi: 10.1021/bi00198a001. Biochemistry. 1994. PMID: 8068613
This PTP, reconstituted in liposomes, catalyzes phosphate uptake with a Vmax [24.5 degrees C, net (zero trans), pHi = 8.0, pHe = 6.8] of 0.61 mmol of phosphate min-1 (mg of PTP)-1 and a Km of 1.30 mM. ...Replacement of Thr43 and Ile141 by other amino acids results in three …
This PTP, reconstituted in liposomes, catalyzes phosphate uptake with a Vmax [24.5 degrees C, net (zero trans), pHi = 8.0, pHe = 6.8] …
Mitochondrial phosphate transport protein. Reversions of inhibitory conservative mutations identify four helices and a nonhelix protein segment with transmembrane interactions and Asp39, Glu137, and Ser158 as nonessential for transport.
Phelps A, Briggs C, Haefele A, Mincone L, Ligeti E, Wohlrab H. Phelps A, et al. Biochemistry. 2001 Feb 20;40(7):2080-6. doi: 10.1021/bi002206i. Biochemistry. 2001. PMID: 11329276
In earlier studies, conservative replacements of several residues located either at the matrix end (Asp39/helix A, Glu137/helix C, Asp236/helix E) or at the membrane center (His32/helix A, Glu136/helix C) of TM helices yielded inactive single mutation PTPs. ...We co …
In earlier studies, conservative replacements of several residues located either at the matrix end (Asp39/helix A, Glu137/helix C, As …
Mitochondrial phosphate transport protein. replacements of glutamic, aspartic, and histidine residues affect transport and protein conformation and point to a coupled proton transport path.
Phelps A, Briggs C, Mincone L, Wohlrab H. Phelps A, et al. Biochemistry. 1996 Aug 20;35(33):10757-62. doi: 10.1021/bi961052x. Biochemistry. 1996. PMID: 8718866
Five residues appear critical for transport: His-32 in helix A, Glu-126 and -137 in helix C, and Asp-39 and -236 at the matrix ends of helices A and E. ...Only the Glu95Gln (cytosolic helices B and C-connecting segment), Glu163Gln and Glu164Gln (matrix helices C
Five residues appear critical for transport: His-32 in helix A, Glu-126 and -137 in helix C, and Asp-39 and -236 at the matrix ends o …
Replacements of basic and hydroxyl amino acids identify structurally and functionally sensitive regions of the mitochondrial phosphate transport protein.
Briggs C, Mincone L, Wohlrab H. Briggs C, et al. Biochemistry. 1999 Apr 20;38(16):5096-102. doi: 10.1021/bi982945n. Biochemistry. 1999. PMID: 10213613
Two of these three mutations are located in the loop connecting the matrix ends of helices C and D, Ser145 at its N-terminal (the matrix end of helix C) and Arg159 near its center. Lys295 is located at the C-terminal of PTP beyond helix F. These results, toge …
Two of these three mutations are located in the loop connecting the matrix ends of helices C and D, Ser145 at its N-terminal (the mat …
Lymphocyte aging in bone marrow chimeras.
Armstrong MJ, Janick-Buckner D, Harvey N, Briggs CJ, Warner CM. Armstrong MJ, et al. Growth Dev Aging. 1993 Winter;57(4):251-60. Growth Dev Aging. 1993. PMID: 8300278
Lymphocyte aging in allophenic mice.
Warner CM, Briggs CJ, Meyer TE, Spannaus DJ, Yang HY, Balinsky D. Warner CM, et al. Exp Gerontol. 1985;20(1):35-45. doi: 10.1016/0531-5565(85)90007-5. Exp Gerontol. 1985. PMID: 3858101
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