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The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans.
Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10417-22. doi: 10.1073/pnas.152161099. Epub 2002 Jul 16.
Proc Natl Acad Sci U S A. 2002.
PMID: 12122205
Free PMC article.
Progressive disruption of cellular protein folding in models of polyglutamine diseases.
Gidalevitz T, Ben-Zvi A, Ho KH, Brignull HR, Morimoto RI.
Gidalevitz T, et al. Among authors: brignull hr.
Science. 2006 Mar 10;311(5766):1471-4. doi: 10.1126/science.1124514. Epub 2006 Feb 9.
Science. 2006.
PMID: 16469881
Item in Clipboard
Polyglutamine proteins at the pathogenic threshold display neuron-specific aggregation in a pan-neuronal Caenorhabditis elegans model.
Brignull HR, Moore FE, Tang SJ, Morimoto RI.
Brignull HR, et al.
J Neurosci. 2006 Jul 19;26(29):7597-606. doi: 10.1523/JNEUROSCI.0990-06.2006.
J Neurosci. 2006.
PMID: 16855087
Free PMC article.
Item in Clipboard
Modeling polyglutamine pathogenesis in C. elegans.
Brignull HR, Morley JF, Garcia SM, Morimoto RI.
Brignull HR, et al.
Methods Enzymol. 2006;412:256-82. doi: 10.1016/S0076-6879(06)12016-9.
Methods Enzymol. 2006.
PMID: 17046663
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The stress of misfolded proteins: C. elegans models for neurodegenerative disease and aging.
Brignull HR, Morley JF, Morimoto RI.
Brignull HR, et al.
Adv Exp Med Biol. 2007;594:167-89. doi: 10.1007/978-0-387-39975-1_15.
Adv Exp Med Biol. 2007.
PMID: 17205684
Review.
Item in Clipboard
Neuron-specific proteotoxicity of mutant ataxin-3 in C. elegans: rescue by the DAF-16 and HSF-1 pathways.
Teixeira-Castro A, Ailion M, Jalles A, Brignull HR, Vilaça JL, Dias N, Rodrigues P, Oliveira JF, Neves-Carvalho A, Morimoto RI, Maciel P.
Teixeira-Castro A, et al. Among authors: brignull hr.
Hum Mol Genet. 2011 Aug 1;20(15):2996-3009. doi: 10.1093/hmg/ddr203. Epub 2011 May 5.
Hum Mol Genet. 2011.
PMID: 21546381
Free PMC article.
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Feathers and fins: non-mammalian models for hair cell regeneration.
Brignull HR, Raible DW, Stone JS.
Brignull HR, et al.
Brain Res. 2009 Jun 24;1277:12-23. doi: 10.1016/j.brainres.2009.02.028. Epub 2009 Feb 24.
Brain Res. 2009.
PMID: 19245801
Free PMC article.
Review.
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