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The androgen receptor in LNCaP cells contains a mutation in the ligand binding domain which affects steroid binding characteristics and response to antiandrogens.
Veldscholte J, Berrevoets CA, Ris-Stalpers C, Kuiper GG, Jenster G, Trapman J, Brinkmann AO, Mulder E. Veldscholte J, et al. Among authors: brinkmann ao. J Steroid Biochem Mol Biol. 1992 Mar;41(3-8):665-9. doi: 10.1016/0960-0760(92)90401-4. J Steroid Biochem Mol Biol. 1992. PMID: 1562539 Review.
Antiandrogens: selective androgen receptor modulators.
Berrevoets CA, Umar A, Brinkmann AO. Berrevoets CA, et al. Among authors: brinkmann ao. Mol Cell Endocrinol. 2002 Dec 30;198(1-2):97-103. doi: 10.1016/s0303-7207(02)00373-8. Mol Cell Endocrinol. 2002. PMID: 12573819 Review.
Molecular basis of androgen insensitivity.
Brinkmann A, Jenster G, Ris-Stalpers C, van der Korput H, Brüggenwirth H, Boehmer A, Trapman J. Brinkmann A, et al. Steroids. 1996 Apr;61(4):172-5. doi: 10.1016/0039-128x(96)00008-6. Steroids. 1996. PMID: 8732995 Free article. Review.
Functional domains of the human androgen receptor.
Jenster G, van der Korput JA, Trapman J, Brinkmann AO. Jenster G, et al. Among authors: brinkmann ao. J Steroid Biochem Mol Biol. 1992 Mar;41(3-8):671-5. doi: 10.1016/0960-0760(92)90402-5. J Steroid Biochem Mol Biol. 1992. PMID: 1562540
191 results