Broadhurst MJ - Search Results

1

Potent collagenase inhibitors prevent interleukin-1-induced cartilage degradation in vitro.

Nixon JS, Bottomley KM, Broadhurst MJ, Brown PA, Johnson WH, Lawton G, Marley J, Sedgwick AD, Wilkinson SE. Nixon JS, et al. Among authors: broadhurst mj. Int J Tissue React. 1991;13(5):237-41. Int J Tissue React. 1991. PMID: 1666894

2

Inhibition of bovine nasal cartilage degradation by selective matrix metalloproteinase inhibitors.

Bottomley KM, Borkakoti N, Bradshaw D, Brown PA, Broadhurst MJ, Budd JM, Elliott L, Eyers P, Hallam TJ, Handa BK, Hill CH, James M, Lahm HW, Lawton G, Merritt JE, Nixon JS, Röthlisberger U, Whittle A, Johnson WH. Bottomley KM, et al. Among authors: broadhurst mj. Biochem J. 1997 Apr 15;323 ( Pt 2)(Pt 2):483-8. doi: 10.1042/bj3230483. Biochem J. 1997. PMID: 9163342 Free PMC article.

3

Ro 32-3555, an orally active collagenase inhibitor, prevents cartilage breakdown in vitro and in vivo.

Lewis EJ, Bishop J, Bottomley KM, Bradshaw D, Brewster M, Broadhurst MJ, Brown PA, Budd JM, Elliott L, Greenham AK, Johnson WH, Nixon JS, Rose F, Sutton B, Wilson K. Lewis EJ, et al. Among authors: broadhurst mj. Br J Pharmacol. 1997 Jun;121(3):540-6. doi: 10.1038/sj.bjp.0701150. Br J Pharmacol. 1997. PMID: 9179398 Free PMC article.

4

1H-NMR and protection studies of interactions between ligands and bovine pancreatic phospholipase A2.

Williamson MP, Davis PD, Broadhurst MJ, Nixon JS. Williamson MP, et al. Among authors: broadhurst mj. Biochim Biophys Acta. 1989 Jul 27;997(1-2):9-14. doi: 10.1016/0167-4838(89)90129-5. Biochim Biophys Acta. 1989. PMID: 2752056

5

Structure of the catalytic domain of human fibroblast collagenase complexed with an inhibitor.

Borkakoti N, Winkler FK, Williams DH, D'Arcy A, Broadhurst MJ, Brown PA, Johnson WH, Murray EJ. Borkakoti N, et al. Among authors: broadhurst mj. Nat Struct Biol. 1994 Feb;1(2):106-10. doi: 10.1038/nsb0294-106. Nat Struct Biol. 1994. PMID: 7656013

6

(E)-2(R)-[1(S)-(Hydroxycarbamoyl)-4-phenyl-3-butenyl]-2'-isobutyl-2'-(methanesulfonyl)-4-methylvalerohydrazide (Ro 32-7315), a selective and orally active inhibitor of tumor necrosis factor-alpha convertase.

Beck G, Bottomley G, Bradshaw D, Brewster M, Broadhurst M, Devos R, Hill C, Johnson W, Kim HJ, Kirtland S, Kneer J, Lad N, Mackenzie R, Martin R, Nixon J, Price G, Rodwell A, Rose F, Tang JP, Walter DS, Wilson K, Worth E. Beck G, et al. J Pharmacol Exp Ther. 2002 Jul;302(1):390-6. doi: 10.1124/jpet.302.1.390. J Pharmacol Exp Ther. 2002. PMID: 12065742

7

Discovery of novel low molecular weight inhibitors of IMPDH via virtual needle screening.

Pickett SD, Sherborne BS, Wilkinson T, Bennett J, Borkakoti N, Broadhurst M, Hurst D, Kilford I, McKinnell M, Jones PS. Pickett SD, et al. Bioorg Med Chem Lett. 2003 May 19;13(10):1691-4. doi: 10.1016/s0960-894x(03)00237-3. Bioorg Med Chem Lett. 2003. PMID: 12729643

8

Synthesis and antitumor activity of 9-[(carbamoyloxy)alkyl]anthracyclines: a novel class of anthracycline derivatives.

Adams N, Blake C, Broadhurst MJ, Bushnell DJ, Hassall CH, Hartmann HR, Keech E, Stratton AR, Thomas GJ. Adams N, et al. Among authors: broadhurst mj. J Med Chem. 1990 Sep;33(9):2380-4. doi: 10.1021/jm00171a011. J Med Chem. 1990. PMID: 2391682

9

Synthesis and antitumor activity of novel 4-demethoxyanthracyclines.

Adams N, Blake C, Broadhurst MJ, Bushnell DJ, Hassall CH, Hartmann HR, Keech E, Stratton AR, Thomas GJ. Adams N, et al. Among authors: broadhurst mj. J Med Chem. 1990 Sep;33(9):2375-9. doi: 10.1021/jm00171a010. J Med Chem. 1990. PMID: 2391681

10

9-alkyl anthracyclines. Absence of cross-resistance to adriamycin in human and murine cell cultures.

Scott CA, Westmacott D, Broadhurst MJ, Thomas GJ, Hall MJ. Scott CA, et al. Among authors: broadhurst mj. Br J Cancer. 1986 May;53(5):595-600. doi: 10.1038/bjc.1986.101. Br J Cancer. 1986. PMID: 3718817 Free PMC article.

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