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IL-4 is the key regulator in herpes simplex virus-based gene therapy of BALB/c experimental autoimmune encephalomyelitis.
Broberg EK, Salmi AA, Hukkanen V. Broberg EK, et al. Neurosci Lett. 2004 Jul 8;364(3):173-8. doi: 10.1016/j.neulet.2004.04.059. Neurosci Lett. 2004. PMID: 15196670
Herpes simplex virus type 1 Us3 gene deletion influences toll-like receptor responses in cultured monocytic cells.
Peri P, Mattila RK, Kantola H, Broberg E, Karttunen HS, Waris M, Vuorinen T, Hukkanen V. Peri P, et al. Among authors: broberg e. Virol J. 2008 Nov 21;5:140. doi: 10.1186/1743-422X-5-140. Virol J. 2008. PMID: 19025601 Free PMC article.
Cytokines in experimental herpes simplex virus infection.
Hukkanen V, Broberg E, Salmi A, Erälinna JP. Hukkanen V, et al. Among authors: broberg e. Int Rev Immunol. 2002 Jul-Oct;21(4-5):355-71. doi: 10.1080/08830180213276. Int Rev Immunol. 2002. PMID: 12486819 Review.
Herpesviruses in brains in Alzheimer's and Parkinson's diseases.
Hemling N, Röyttä M, Rinne J, Pöllänen P, Broberg E, Tapio V, Vahlberg T, Hukkanen V. Hemling N, et al. Among authors: broberg e. Ann Neurol. 2003 Aug;54(2):267-71. doi: 10.1002/ana.10662. Ann Neurol. 2003. PMID: 12891684
Expression of interleukin-4 but not of interleukin-10 from a replicative herpes simplex virus type 1 viral vector precludes experimental allergic encephalomyelitis.
Broberg E, Setälä N, Röyttä M, Salmi A, Erälinna JP, He B, Roizman B, Hukkanen V. Broberg E, et al. Gene Ther. 2001 May;8(10):769-77. doi: 10.1038/sj.gt.3301465. Gene Ther. 2001. PMID: 11420640
Semliki Forest virus infection is enhanced in Th1-prone SJL mice but not in Th2-prone BALB/c mice during Linomide-induced immunomodulation.
Peltoniemi J, Setälä N, Broberg E, Röyttä M, Hukkanen V, Salmi AA, Erälinna JP. Peltoniemi J, et al. Among authors: broberg e. J Neuroimmunol. 2002 Nov;132(1-2):83-92. doi: 10.1016/s0165-5728(02)00312-0. J Neuroimmunol. 2002. PMID: 12417437
Expression of LIF and LIF receptor beta in Alzheimer's and Parkinson's diseases.
Soilu-Hänninen M, Broberg E, Röyttä M, Mattila P, Rinne J, Hukkanen V. Soilu-Hänninen M, et al. Among authors: broberg e. Acta Neurol Scand. 2010 Jan;121(1):44-50. doi: 10.1111/j.1600-0404.2009.01179.x. Acta Neurol Scand. 2010. PMID: 20074285
Enhancement of Th2 responses to replicative herpes simplex virus type 1 vectors by immunomodulative chemotherapy.
Peltoniemi J, Broberg EK, Nygårdas M, Erälinna JP, Waris M, Hukkanen V. Peltoniemi J, et al. Among authors: broberg ek. Int Immunopharmacol. 2006 May;6(5):817-29. doi: 10.1016/j.intimp.2005.12.003. Epub 2006 Jan 4. Int Immunopharmacol. 2006. PMID: 16546713
Immune response to herpes simplex virus and gamma134.5 deleted HSV vectors.
Broberg EK, Hukkanen V. Broberg EK, et al. Curr Gene Ther. 2005 Oct;5(5):523-30. doi: 10.2174/156652305774329267. Curr Gene Ther. 2005. PMID: 16250892 Review.
Spread and replication of and immune response to gamma134.5-negative herpes simplex virus type 1 vectors in BALB/c mice.
Broberg EK, Peltoniemi J, Nygårdas M, Vahlberg T, Röyttä M, Hukkanen V. Broberg EK, et al. J Virol. 2004 Dec;78(23):13139-52. doi: 10.1128/JVI.78.23.13139-13152.2004. J Virol. 2004. PMID: 15542666 Free PMC article.
We have previously shown that intracranial infection of herpes simplex virus type 1 (HSV-1) vector R8306 expressing interleukin-4 (IL-4) can abolish symptoms of experimental autoimmune encephalomyelitis, which is used as a model for human multiple sclerosis (Broberg et al. …
We have previously shown that intracranial infection of herpes simplex virus type 1 (HSV-1) vector R8306 expressing interleukin-4 (IL-4) can …
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