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The regulation of immunoglobulin E class-switch recombination.
Geha RS, Jabara HH, Brodeur SR. Geha RS, et al. Among authors: brodeur sr. Nat Rev Immunol. 2003 Sep;3(9):721-32. doi: 10.1038/nri1181. Nat Rev Immunol. 2003. PMID: 12949496 Review.
Ligation of CD46 to CD40 inhibits CD40 signaling in B cells.
Jabara HH, Angelini F, Brodeur SR, Geha RS. Jabara HH, et al. Among authors: brodeur sr. Int Immunol. 2011 Mar;23(3):215-21. doi: 10.1093/intimm/dxq474. Int Immunol. 2011. PMID: 21393637 Free PMC article.
Human nuclear factor kappa B essential modulator mutation can result in immunodeficiency without ectodermal dysplasia.
Orange JS, Levy O, Brodeur SR, Krzewski K, Roy RM, Niemela JE, Fleisher TA, Bonilla FA, Geha RS. Orange JS, et al. Among authors: brodeur sr. J Allergy Clin Immunol. 2004 Sep;114(3):650-6. doi: 10.1016/j.jaci.2004.06.052. J Allergy Clin Immunol. 2004. PMID: 15356572
C4b-binding protein (C4BP) activates B cells through the CD40 receptor.
Brodeur SR, Angelini F, Bacharier LB, Blom AM, Mizoguchi E, Fujiwara H, Plebani A, Notarangelo LD, Dahlback B, Tsitsikov E, Geha RS. Brodeur SR, et al. Immunity. 2003 Jun;18(6):837-48. doi: 10.1016/s1074-7613(03)00149-3. Immunity. 2003. PMID: 12818164 Free article.
The binding site for TRAF2 and TRAF3 but not for TRAF6 is essential for CD40-mediated immunoglobulin class switching.
Jabara H, Laouini D, Tsitsikov E, Mizoguchi E, Bhan A, Castigli E, Dedeoglu F, Pivniouk V, Brodeur S, Geha R. Jabara H, et al. Among authors: brodeur s. Immunity. 2002 Sep;17(3):265-76. doi: 10.1016/s1074-7613(02)00394-1. Immunity. 2002. PMID: 12354380
The anaphylatoxin C3a downregulates the Th2 response to epicutaneously introduced antigen.
Kawamoto S, Yalcindag A, Laouini D, Brodeur S, Bryce P, Lu B, Humbles AA, Oettgen H, Gerard C, Geha RS. Kawamoto S, et al. Among authors: brodeur s. J Clin Invest. 2004 Aug;114(3):399-407. doi: 10.1172/JCI19082. J Clin Invest. 2004. PMID: 15286806 Free PMC article.
Glucocorticoids upregulate CD40 ligand expression and induce CD40L-dependent immunoglobulin isotype switching.
Jabara HH, Brodeur SR, Geha RS. Jabara HH, et al. Among authors: brodeur sr. J Clin Invest. 2001 Feb;107(3):371-8. doi: 10.1172/JCI10168. J Clin Invest. 2001. PMID: 11160161 Free PMC article.
An obligate role for T-cell receptor alphabeta+ T cells but not T-cell receptor gammadelta+ T cells, B cells, or CD40/CD40L interactions in a mouse model of atopic dermatitis.
Woodward AL, Spergel JM, Alenius H, Mizoguchi E, Bhan AK, Castigli E, Brodeur SR, Oettgen HC, Geha RS. Woodward AL, et al. Among authors: brodeur sr. J Allergy Clin Immunol. 2001 Feb;107(2):359-66. doi: 10.1067/mai.2001.112695. J Allergy Clin Immunol. 2001. PMID: 11174205
Deficient natural killer cell cytotoxicity in patients with IKK-gamma/NEMO mutations.
Orange JS, Brodeur SR, Jain A, Bonilla FA, Schneider LC, Kretschmer R, Nurko S, Rasmussen WL, Köhler JR, Gellis SE, Ferguson BM, Strominger JL, Zonana J, Ramesh N, Ballas ZK, Geha RS. Orange JS, et al. Among authors: brodeur sr. J Clin Invest. 2002 Jun;109(11):1501-9. doi: 10.1172/JCI14858. J Clin Invest. 2002. PMID: 12045264 Free PMC article.
Localization of the major NF-kappaB-activating site and the sole TRAF3 binding site of LMP-1 defines two distinct signaling motifs.
Brodeur SR, Cheng G, Baltimore D, Thorley-Lawson DA. Brodeur SR, et al. J Biol Chem. 1997 Aug 8;272(32):19777-84. doi: 10.1074/jbc.272.32.19777. J Biol Chem. 1997. PMID: 9242637 Free article.
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