Brosey CA - Search Results

1

An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2.

Moiani D, Link TM, Brosey CA, Katsonis P, Lichtarge O, Kim Y, Joachimiak A, Ma Z, Kim IK, Ahmed Z, Jones DE, Tsutakawa SE, Tainer JA. Moiani D, et al. Among authors: brosey ca. Methods Enzymol. 2021;661:407-431. doi: 10.1016/bs.mie.2021.09.003. Epub 2021 Sep 27. Methods Enzymol. 2021. PMID: 34776222 Free PMC article.

2

Structural dynamics and single-stranded DNA binding activity of the three N-terminal domains of the large subunit of replication protein A from small angle X-ray scattering.

Pretto DI, Tsutakawa S, Brosey CA, Castillo A, Chagot ME, Smith JA, Tainer JA, Chazin WJ. Pretto DI, et al. Among authors: brosey ca. Biochemistry. 2010 Apr 6;49(13):2880-9. doi: 10.1021/bi9019934. Biochemistry. 2010. PMID: 20184389 Free PMC article.

3

Sample preparation methods to analyze DNA-induced structural changes in replication protein A.

Brosey CA, Tsutakawa SE, Chazin WJ. Brosey CA, et al. Methods Mol Biol. 2012;922:101-22. doi: 10.1007/978-1-62703-032-8_6. Methods Mol Biol. 2012. PMID: 22976179 Free PMC article.

4

A new structural framework for integrating replication protein A into DNA processing machinery.

Brosey CA, Yan C, Tsutakawa SE, Heller WT, Rambo RP, Tainer JA, Ivanov I, Chazin WJ. Brosey CA, et al. Nucleic Acids Res. 2013 Feb 1;41(4):2313-27. doi: 10.1093/nar/gks1332. Epub 2013 Jan 8. Nucleic Acids Res. 2013. PMID: 23303776 Free PMC article.

5

A quantitative assay reveals ligand specificity of the DNA scaffold repair protein XRCC1 and efficient disassembly of complexes of XRCC1 and the poly(ADP-ribose) polymerase 1 by poly(ADP-ribose) glycohydrolase.

Kim IK, Stegeman RA, Brosey CA, Ellenberger T. Kim IK, et al. Among authors: brosey ca. J Biol Chem. 2015 Feb 6;290(6):3775-83. doi: 10.1074/jbc.M114.624718. Epub 2014 Dec 4. J Biol Chem. 2015. PMID: 25477519 Free PMC article.

6

Defining NADH-Driven Allostery Regulating Apoptosis-Inducing Factor.

Brosey CA, Ho C, Long WZ, Singh S, Burnett K, Hura GL, Nix JC, Bowman GR, Ellenberger T, Tainer JA. Brosey CA, et al. Structure. 2016 Dec 6;24(12):2067-2079. doi: 10.1016/j.str.2016.09.012. Epub 2016 Nov 3. Structure. 2016. PMID: 27818101 Free PMC article.

7

What Combined Measurements From Structures and Imaging Tell Us About DNA Damage Responses.

Brosey CA, Ahmed Z, Lees-Miller SP, Tainer JA. Brosey CA, et al. Methods Enzymol. 2017;592:417-455. doi: 10.1016/bs.mie.2017.04.005. Epub 2017 May 29. Methods Enzymol. 2017. PMID: 28668129 Free PMC article. Review.

8

Targeting Allostery with Avatars to Design Inhibitors Assessed by Cell Activity: Dissecting MRE11 Endo- and Exonuclease Activities.

Moiani D, Ronato DA, Brosey CA, Arvai AS, Syed A, Masson JY, Petricci E, Tainer JA. Moiani D, et al. Among authors: brosey ca. Methods Enzymol. 2018;601:205-241. doi: 10.1016/bs.mie.2017.11.030. Epub 2018 Feb 22. Methods Enzymol. 2018. PMID: 29523233 Free PMC article.

9

Evolving SAXS versatility: solution X-ray scattering for macromolecular architecture, functional landscapes, and integrative structural biology.

Brosey CA, Tainer JA. Brosey CA, et al. Curr Opin Struct Biol. 2019 Oct;58:197-213. doi: 10.1016/j.sbi.2019.04.004. Epub 2019 Jun 13. Curr Opin Struct Biol. 2019. PMID: 31204190 Free PMC article. Review.

10

Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.

Houl JH, Ye Z, Brosey CA, Balapiti-Modarage LPF, Namjoshi S, Bacolla A, Laverty D, Walker BL, Pourfarjam Y, Warden LS, Babu Chinnam N, Moiani D, Stegeman RA, Chen MK, Hung MC, Nagel ZD, Ellenberger T, Kim IK, Jones DE, Ahmed Z, Tainer JA. Houl JH, et al. Among authors: brosey ca. Nat Commun. 2019 Dec 11;10(1):5654. doi: 10.1038/s41467-019-13508-4. Nat Commun. 2019. PMID: 31827085 Free PMC article.

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