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Caspase-1: is IL-1 just the tip of the ICEberg?
Denes A, Lopez-Castejon G, Brough D. Denes A, et al. Cell Death Dis. 2012 Jul 5;3(7):e338. doi: 10.1038/cddis.2012.86. Cell Death Dis. 2012. PMID: 22764097 Free PMC article. Review.
Priming of macrophages with lipopolysaccharide potentiates P2X7-mediated cell death via a caspase-1-dependent mechanism, independently of cytokine production.
Le Feuvre RA, Brough D, Iwakura Y, Takeda K, Rothwell NJ. Le Feuvre RA, et al. J Biol Chem. 2002 Feb 1;277(5):3210-8. doi: 10.1074/jbc.M104388200. Epub 2001 Nov 12. J Biol Chem. 2002. PMID: 11706016
Extracellular ATP and P2X7 receptors in neurodegeneration.
Le Feuvre R, Brough D, Rothwell N. Le Feuvre R, et al. Eur J Pharmacol. 2002 Jul 5;447(2-3):261-9. doi: 10.1016/s0014-2999(02)01848-4. Eur J Pharmacol. 2002. PMID: 12151017 Review.
Role of P2X7 receptors in ischemic and excitotoxic brain injury in vivo.
Le Feuvre RA, Brough D, Touzani O, Rothwell NJ. Le Feuvre RA, et al. J Cereb Blood Flow Metab. 2003 Mar;23(3):381-4. doi: 10.1097/01.WCB.0000048519.34839.97. J Cereb Blood Flow Metab. 2003. PMID: 12621313
Ca2+ stores and Ca2+ entry differentially contribute to the release of IL-1 beta and IL-1 alpha from murine macrophages.
Brough D, Le Feuvre RA, Wheeler RD, Solovyova N, Hilfiker S, Rothwell NJ, Verkhratsky A. Brough D, et al. J Immunol. 2003 Mar 15;170(6):3029-36. doi: 10.4049/jimmunol.170.6.3029. J Immunol. 2003. PMID: 12626557
Interleukin-18 induces expression and release of cytokines from murine glial cells: interactions with interleukin-1 beta.
Wheeler RD, Brough D, Le Feuvre RA, Takeda K, Iwakura Y, Luheshi GN, Rothwell NJ. Wheeler RD, et al. J Neurochem. 2003 Jun;85(6):1412-20. doi: 10.1046/j.1471-4159.2003.01787.x. J Neurochem. 2003. PMID: 12787061
Mechanisms of regulation for interleukin-1beta in neurodegenerative disease.
Simi A, Lerouet D, Pinteaux E, Brough D. Simi A, et al. Neuropharmacology. 2007 Jun;52(8):1563-9. doi: 10.1016/j.neuropharm.2007.02.011. Epub 2007 Mar 12. Neuropharmacology. 2007. PMID: 17428507 Review.
A selective, non-peptide caspase-1 inhibitor, VRT-018858, markedly reduces brain damage induced by transient ischemia in the rat.
Ross J, Brough D, Gibson RM, Loddick SA, Rothwell NJ. Ross J, et al. Neuropharmacology. 2007 Oct;53(5):638-42. doi: 10.1016/j.neuropharm.2007.07.015. Epub 2007 Aug 10. Neuropharmacology. 2007. PMID: 17845807
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