Broughton HB - Search Results

1

3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor.

Kulagowski JJ, Broughton HB, Curtis NR, Mawer IM, Ridgill MP, Baker R, Emms F, Freedman SB, Marwood R, Patel S, Patel S, Ragan CI, Leeson PD. Kulagowski JJ, et al. Among authors: broughton hb. J Med Chem. 1996 May 10;39(10):1941-2. doi: 10.1021/jm9600712. J Med Chem. 1996. PMID: 8642550 No abstract available.

2

5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole: a potent, selective antagonist at human cloned dopamine D4 receptors.

Rowley M, Broughton HB, Collins I, Baker R, Emms F, Marwood R, Patel S, Patel S, Ragan CI, Freedman SB, Leeson PD. Rowley M, et al. Among authors: broughton hb. J Med Chem. 1996 May 10;39(10):1943-5. doi: 10.1021/jm960072u. J Med Chem. 1996. PMID: 8642551 No abstract available.

3

4-Heterocyclylpiperidines as selective high-affinity ligands at the human dopamine D4 receptor.

Rowley M, Collins I, Broughton HB, Davey WB, Baker R, Emms F, Marwood R, Patel S, Patel S, Ragan CI, Freedman SB, Ball R, Leeson PD. Rowley M, et al. Among authors: broughton hb. J Med Chem. 1997 Jul 18;40(15):2374-85. doi: 10.1021/jm970111h. J Med Chem. 1997. PMID: 9240352

4

5-(Piperidin-2-yl)- and 5-(homopiperidin-2-yl)-1,4-benzodiazepines: high-affinity, basic ligands for the cholecystokinin-B receptor.

Castro JL, Broughton HB, Russell MG, Rathbone D, Watt AP, Ball RG, Chapman KL, Patel S, Smith AJ, Marshall GR, Matassa VG. Castro JL, et al. Among authors: broughton hb. J Med Chem. 1997 Aug 1;40(16):2491-501. doi: 10.1021/jm9608523. J Med Chem. 1997. PMID: 9258356

5

N-Arylsulfonylindole derivatives as serotonin 5-HT(6) receptor ligands.

Russell MG, Baker RJ, Barden L, Beer MS, Bristow L, Broughton HB, Knowles M, McAllister G, Patel S, Castro JL. Russell MG, et al. Among authors: broughton hb. J Med Chem. 2001 Nov 8;44(23):3881-95. doi: 10.1021/jm010943m. J Med Chem. 2001. PMID: 11689074

6

Controlled modification of acidity in cholecystokinin B receptor antagonists: N-(1,4-benzodiazepin-3-yl)-N'-[3-(tetrazol-5-ylamino) phenyl]ureas.

Castro JL, Ball RG, Broughton HB, Russell MG, Rathbone D, Watt AP, Baker R, Chapman KL, Fletcher AE, Patel S, Smith AJ, Marshall GR, Ryecroft W, Matassa VG. Castro JL, et al. Among authors: broughton hb. J Med Chem. 1996 Feb 16;39(4):842-9. doi: 10.1021/jm9506736. J Med Chem. 1996. PMID: 8632408

7

Mechanism of inositol monophosphatase, the putative target of lithium therapy.

Pollack SJ, Atack JR, Knowles MR, McAllister G, Ragan CI, Baker R, Fletcher SR, Iversen LL, Broughton HB. Pollack SJ, et al. Among authors: broughton hb. Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):5766-70. doi: 10.1073/pnas.91.13.5766. Proc Natl Acad Sci U S A. 1994. PMID: 8016062 Free PMC article.

8

Probing the role of metal ions in the mechanism of inositol monophosphatase by site-directed mutagenesis.

Pollack SJ, Knowles MR, Atack JR, Broughton HB, Ragan CI, Osborne S, McAllister G. Pollack SJ, et al. Among authors: broughton hb. Eur J Biochem. 1993 Oct 1;217(1):281-7. doi: 10.1111/j.1432-1033.1993.tb18244.x. Eur J Biochem. 1993. PMID: 8223565 Free article.

9

Photoaffinity labeling of the benzodiazepine binding site of alpha1beta3gamma2 gamma-aminobutyric acidA receptors with flunitrazepam identifies a subset of ligands that interact directly with His102 of the alpha subunit and predicts orientation of these within the benzodiazepine pharmacophore.

McKernan RM, Farrar S, Collins I, Emms F, Asuni A, Quirk K, Broughton H. McKernan RM, et al. Mol Pharmacol. 1998 Jul;54(1):33-43. doi: 10.1124/mol.54.1.33. Mol Pharmacol. 1998. PMID: 9658187

10

Structural analysis of inositol monophosphatase complexes with substrates.

Bone R, Frank L, Springer JP, Pollack SJ, Osborne SA, Atack JR, Knowles MR, McAllister G, Ragan CI, Broughton HB, et al. Bone R, et al. Among authors: broughton hb. Biochemistry. 1994 Aug 16;33(32):9460-7. doi: 10.1021/bi00198a011. Biochemistry. 1994. PMID: 8068620

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