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Extrarenal production of calcitriol.
Dusso A, Brown A, Slatopolsky E. Dusso A, et al. Among authors: brown a. Semin Nephrol. 1994 Mar;14(2):144-55. Semin Nephrol. 1994. PMID: 8177981 Review.
The simultaneous expression of vitamin D receptors, constitutive 1 alpha-hydroxylase, and inducible 24-hydroxylase activity in the same cell or in cells of the nearby environment suggests that they constitute a means for an in situ regulation of the response to vitamin D. …
The simultaneous expression of vitamin D receptors, constitutive 1 alpha-hydroxylase, and inducible 24-hydroxylase activity in the same cell …
New vitamin D analogs.
Slatopolsky E, Finch J, Brown A. Slatopolsky E, et al. Among authors: brown a. Kidney Int Suppl. 2003 Jun;(85):S83-7. doi: 10.1046/j.1523-1755.63.s85.20.x. Kidney Int Suppl. 2003. PMID: 12753273 Review.
CONCLUSION: Therapeutic doses of 19-nor-1,25-(OH)2D2 could produce a lower Ca x P product compared to 1,alpha(OH)D2, which could be an important consideration in patient treatment. ...
CONCLUSION: Therapeutic doses of 19-nor-1,25-(OH)2D2 could produce a lower Ca x P product compared to 1,alpha(OH)D2, which could be a …
Calcium, phosphorus and vitamin D disorders in uremia.
Slatopolsky E, Brown A, Dusso A. Slatopolsky E, et al. Among authors: brown a. Contrib Nephrol. 2005;149:261-271. doi: 10.1159/000085687. Contrib Nephrol. 2005. PMID: 15876849 Review.
METHODOLOGY: Studies were performed in uremic dogs and rats fed a low and high P diet over a period of 1-4 months. In addition, in vitro studies were performed in normal parathyroid glands incubated in culture media containing 0.2 mM P (low) or 2.0 mM P (high). ...I …
METHODOLOGY: Studies were performed in uremic dogs and rats fed a low and high P diet over a period of 1-4 months. In addition …
Cellular expression of the C5a anaphylatoxin receptor (C5aR): demonstration of C5aR on nonmyeloid cells of the liver and lung.
Haviland DL, McCoy RL, Whitehead WT, Akama H, Molmenti EP, Brown A, Haviland JC, Parks WC, Perlmutter DH, Wetsel RA. Haviland DL, et al. Among authors: brown a. J Immunol. 1995 Feb 15;154(4):1861-9. J Immunol. 1995. PMID: 7836770
By Northern blot analysis, it was determined that mouse liver, baboon liver, human liver, and the human hepatoma-derived cell line HepG2 express a normal size (2.3 kb) C5aR mRNA; in HepG2 cells, the quantity of C5aR mRNA was comparable to that contained in dbcAMP-different …
By Northern blot analysis, it was determined that mouse liver, baboon liver, human liver, and the human hepatoma-derived cell line HepG2 exp …
Renal osteodystrophy: past and future.
Slatopolsky E, Lopez-Hilker S, Dusso A, Brown A, Delmez J, Martin K. Slatopolsky E, et al. Among authors: brown a. Contrib Nephrol. 1990;78:38-45; discussion 45-6. doi: 10.1159/000418268. Contrib Nephrol. 1990. PMID: 2225842 Review. No abstract available.
Role of phosphorus in the pathogenesis of secondary hyperparathyroidism.
Slatopolsky E, Brown A, Dusso A. Slatopolsky E, et al. Among authors: brown a. Am J Kidney Dis. 2001 Jan;37(1 Suppl 2):S54-7. doi: 10.1053/ajkd.2001.20740. Am J Kidney Dis. 2001. PMID: 11158862 Review.
As renal disease progresses, a reduction in parathyroid expression of vitamin D receptor and calcium receptor renders the PTG more resistant to both calcitriol and calcium. ...Whereas high dietary P increases parathyroid expression of transforming growth factor alpha (TGFa …
As renal disease progresses, a reduction in parathyroid expression of vitamin D receptor and calcium receptor renders the PTG more re …
New analogs of vitamin D3.
Slatopolsky E, Dusso A, Brown A. Slatopolsky E, et al. Among authors: brown a. Kidney Int Suppl. 1999 Dec;73:S46-51. doi: 10.1046/j.1523-1755.1999.07305.x. Kidney Int Suppl. 1999. PMID: 10633464 Review.
Hyperphosphatemia is also a persistent problem among patients undergoing chronic hemodialysis and can be aggravated by therapeutic doses of calcitriol. ...In some analogs the serum binding protein (DBP) plays a key role in determining the pharmacokinetics of the vit …
Hyperphosphatemia is also a persistent problem among patients undergoing chronic hemodialysis and can be aggravated by therapeutic do …
A new analog of calcitriol, 19-nor-1,25-(OH)2D2, suppresses parathyroid hormone secretion in uremic rats in the absence of hypercalcemia.
Slatopolsky E, Finch J, Ritter C, Denda M, Morrissey J, Brown A, DeLuca H. Slatopolsky E, et al. Among authors: brown a. Am J Kidney Dis. 1995 Nov;26(5):852-60. doi: 10.1016/0272-6386(95)90455-7. Am J Kidney Dis. 1995. PMID: 7485144
We have studied a new analog of calcitriol, 19-nor-1 alpha,25-(OH)2D2, that possesses low calcemic and phosphatemic activity. ...The maximum effect was achieved with the 75 ng/rat dose, which decreased PTH from 193 +/- 49 to 53 +/- 16 pg/mL (a decrease in 72.5%)....
We have studied a new analog of calcitriol, 19-nor-1 alpha,25-(OH)2D2, that possesses low calcemic and phosphatemic activity. ...The …
Metabolic clearance rate and production rate of calcitriol in uremia.
Dusso A, Lopez-Hilker S, Lewis-Finch J, Grooms P, Brown A, Martin K, Slatopolsky E. Dusso A, et al. Among authors: brown a. Kidney Int. 1989 Mar;35(3):860-4. doi: 10.1038/ki.1989.64. Kidney Int. 1989. PMID: 2709678
Extrarenal production of calcitriol.
Dusso A, Finch J, Delmez J, Rapp N, Lopez-Hilker S, Brown A, Slatopolsky E. Dusso A, et al. Among authors: brown a. Kidney Int Suppl. 1990 Sep;29:S36-40. Kidney Int Suppl. 1990. PMID: 2214546
Under normal circumstances extrarenal sources of calcitriol probably constitutes a microendocrine system involved in cell differentiation and local intercellular communication with no influence on systemic calcium homeostasis. ...
Under normal circumstances extrarenal sources of calcitriol probably constitutes a microendocrine system involved in cell differentia …
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