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The riluzole derivative 2-amino-6-trifluoromethylthio-benzothiazole (SKA-19), a mixed KCa2 activator and NaV blocker, is a potent novel anticonvulsant.
Coleman N, Nguyen HM, Cao Z, Brown BM, Jenkins DP, Zolkowska D, Chen YJ, Tanaka BS, Goldin AL, Rogawski MA, Pessah IN, Wulff H. Coleman N, et al. Neurotherapeutics. 2015 Jan;12(1):234-49. doi: 10.1007/s13311-014-0305-y. Neurotherapeutics. 2015. PMID: 25256961 Free PMC article.
A novel pan-negative-gating modulator of KCa2/3 channels, fluoro-di-benzoate, RA-2, inhibits endothelium-derived hyperpolarization-type relaxation in coronary artery and produces bradycardia in vivo.
Oliván-Viguera A, Valero MS, Coleman N, Brown BM, Laría C, Murillo MD, Gálvez JA, Díaz-de-Villegas MD, Wulff H, Badorrey R, Köhler R. Oliván-Viguera A, et al. Mol Pharmacol. 2015 Feb;87(2):338-48. doi: 10.1124/mol.114.095745. Epub 2014 Dec 2. Mol Pharmacol. 2015. PMID: 25468883 Free PMC article.
Positive allosteric modulators of α7 nicotinic acetylcholine receptors affect neither the function of other ligand- and voltage-gated ion channels and acetylcholinesterase, nor β-amyloid content.
Arias HR, Ravazzini F, Targowska-Duda KM, Kaczor AA, Feuerbach D, Boffi JC, Draczkowski P, Montag D, Brown BM, Elgoyhen AB, Jozwiak K, Puia G. Arias HR, et al. Int J Biochem Cell Biol. 2016 Jul;76:19-30. doi: 10.1016/j.biocel.2016.04.015. Epub 2016 Apr 26. Int J Biochem Cell Biol. 2016. PMID: 27129924
Are there superagonists for calcium-activated potassium channels?
Brown BM, Shim H, Wulff H. Brown BM, et al. Channels (Austin). 2017 Nov 2;11(6):504-506. doi: 10.1080/19336950.2017.1376971. Epub 2017 Oct 5. Channels (Austin). 2017. PMID: 28876978 Free PMC article. No abstract available.
The Trials and Tribulations of Structure Assisted Design of KCa Channel Activators.
Shim H, Brown BM, Singh L, Singh V, Fettinger JC, Yarov-Yarovoy V, Wulff H. Shim H, et al. Among authors: Brown BM. Front Pharmacol. 2019 Sep 20;10:972. doi: 10.3389/fphar.2019.00972. eCollection 2019. Front Pharmacol. 2019. PMID: 31616290 Free PMC article.
Conditional KCa3.1-transgene induction in murine skin produces pruritic eczematous dermatitis with severe epidermal hyperplasia and hyperkeratosis.
Lozano-Gerona J, Oliván-Viguera A, Delgado-Wicke P, Singh V, Brown BM, Tapia-Casellas E, Pueyo E, Valero MS, Garcia-Otín ÁL, Giraldo P, Abarca-Lachen E, Surra JC, Osada J, Hamilton KL, Raychaudhuri SP, Marigil M, Juarranz Á, Wulff H, Miura H, Gilaberte Y, Köhler R. Lozano-Gerona J, et al. Among authors: Brown BM. PLoS One. 2020 Mar 9;15(3):e0222619. doi: 10.1371/journal.pone.0222619. eCollection 2020. PLoS One. 2020. PMID: 32150577 Free PMC article.
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