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Random genetic drift determines the level of mutant mtDNA in human primary oocytes.
Brown DT, Samuels DC, Michael EM, Turnbull DM, Chinnery PF. Brown DT, et al. Am J Hum Genet. 2001 Feb;68(2):533-6. doi: 10.1086/318190. Epub 2000 Dec 29. Am J Hum Genet. 2001. PMID: 11133360 Free PMC article.
Progressive depletion of mtDNA in mitochondrial myopathy.
Durham SE, Brown DT, Turnbull DM, Chinnery PF. Durham SE, et al. Among authors: brown dt. Neurology. 2006 Aug 8;67(3):502-4. doi: 10.1212/01.wnl.0000227961.55640.2f. Neurology. 2006. PMID: 16894115
Spinocerebellar ataxia and the A3243G and A8344G mtDNA mutations.
Chinnery PF, Brown DT, Archibald K, Curtis A, Turnbull DM. Chinnery PF, et al. Among authors: brown dt. J Med Genet. 2002 May;39(5):E22. doi: 10.1136/jmg.39.5.e22. J Med Genet. 2002. PMID: 12011163 Free PMC article. No abstract available.
Transmission of mitochondrial DNA disorders: possibilities for the future.
Brown DT, Herbert M, Lamb VK, Chinnery PF, Taylor RW, Lightowlers RN, Craven L, Cree L, Gardner JL, Turnbull DM. Brown DT, et al. Lancet. 2006 Jul 1;368(9529):87-9. doi: 10.1016/S0140-6736(06)68972-1. Lancet. 2006. PMID: 16815383 No abstract available.
The epidemiology of Leber hereditary optic neuropathy in the North East of England.
Yu-Wai-Man P, Griffiths PG, Brown DT, Howell N, Turnbull DM, Chinnery PF. Yu-Wai-Man P, et al. Among authors: brown dt. Am J Hum Genet. 2003 Feb;72(2):333-9. doi: 10.1086/346066. Epub 2002 Jan 7. Am J Hum Genet. 2003. PMID: 12518276 Free PMC article.
The mitochondrial ND6 gene is a hot spot for mutations that cause Leber's hereditary optic neuropathy.
Chinnery PF, Brown DT, Andrews RM, Singh-Kler R, Riordan-Eva P, Lindley J, Applegarth DA, Turnbull DM, Howell N. Chinnery PF, et al. Among authors: brown dt. Brain. 2001 Jan;124(Pt 1):209-18. doi: 10.1093/brain/124.1.209. Brain. 2001. PMID: 11133798
Point mutations of the mtDNA control region in normal and neurodegenerative human brains.
Chinnery PF, Taylor GA, Howell N, Brown DT, Parsons TJ, Turnbull DM. Chinnery PF, et al. Among authors: brown dt. Am J Hum Genet. 2001 Feb;68(2):529-32. doi: 10.1086/318204. Epub 2000 Dec 21. Am J Hum Genet. 2001. PMID: 11133363 Free PMC article.
The epidemiology of pathogenic mitochondrial DNA mutations.
Chinnery PF, Johnson MA, Wardell TM, Singh-Kler R, Hayes C, Brown DT, Taylor RW, Bindoff LA, Turnbull DM. Chinnery PF, et al. Among authors: brown dt. Ann Neurol. 2000 Aug;48(2):188-93. Ann Neurol. 2000. PMID: 10939569
NDUFA-1 is not a nuclear modifier gene in Leber hereditary optic neuropathy.
Yu-Wai-Man P, Brown DT, Wehnert MS, Zeviani M, Carrara F, Turnbull DM, Chinnery PF. Yu-Wai-Man P, et al. Among authors: brown dt. Neurology. 2002 Jun 25;58(12):1861-2. doi: 10.1212/wnl.58.12.1861. Neurology. 2002. PMID: 12084895 No abstract available.
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