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A signaling pathway to translational control.
Brown EJ, Schreiber SL. Brown EJ, et al. Cell. 1996 Aug 23;86(4):517-20. doi: 10.1016/s0092-8674(00)80125-7. Cell. 1996. PMID: 8752206 Review. No abstract available.
Chemical genomics identifies small-molecule MCL1 repressors and BCL-xL as a predictor of MCL1 dependency.
Wei G, Margolin AA, Haery L, Brown E, Cucolo L, Julian B, Shehata S, Kung AL, Beroukhim R, Golub TR. Wei G, et al. Cancer Cell. 2012 Apr 17;21(4):547-62. doi: 10.1016/j.ccr.2012.02.028. Cancer Cell. 2012. PMID: 22516262 Free PMC article.
An FKBP-rapamycin-sensitive, cyclin-dependent kinase activity that correlates with the FKBP-rapamycin-induced G1 arrest point in MG-63 cells.
Albers MW, Brown EJ, Tanaka A, Williams RT, Hall FL, Schreiber SL. Albers MW, et al. Ann N Y Acad Sci. 1993 Nov 30;696:54-62. doi: 10.1111/j.1749-6632.1993.tb17142.x. Ann N Y Acad Sci. 1993. PMID: 8109857 No abstract available.
A mammalian protein targeted by G1-arresting rapamycin-receptor complex.
Brown EJ, Albers MW, Shin TB, Ichikawa K, Keith CT, Lane WS, Schreiber SL. Brown EJ, et al. Nature. 1994 Jun 30;369(6483):756-8. doi: 10.1038/369756a0. Nature. 1994. PMID: 8008069
Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue.
Chen J, Zheng XF, Brown EJ, Schreiber SL. Chen J, et al. Proc Natl Acad Sci U S A. 1995 May 23;92(11):4947-51. doi: 10.1073/pnas.92.11.4947. Proc Natl Acad Sci U S A. 1995. PMID: 7539137 Free PMC article.
Previously, a mammalian protein that directly associates with FKBP12-rapamycin has been identified and its encoding gene has been cloned from both human (designated FRAP) [Brown, E.J., Albers, M.W., Shin, T.B., Ichikawa, K., Keith, C.T., Lane, W.S. & Schreiber, S.L. (1 …
Previously, a mammalian protein that directly associates with FKBP12-rapamycin has been identified and its encoding gene has been cloned fro …
Control of p70 s6 kinase by kinase activity of FRAP in vivo.
Brown EJ, Beal PA, Keith CT, Chen J, Shin TB, Schreiber SL. Brown EJ, et al. Nature. 1995 Oct 5;377(6548):441-6. doi: 10.1038/377441a0. Nature. 1995. PMID: 7566123
A robust and rapid method of producing soluble, stable, and functional G-protein coupled receptors.
Corin K, Baaske P, Ravel DB, Song J, Brown E, Wang X, Geissler S, Wienken CJ, Jerabek-Willemsen M, Duhr S, Braun D, Zhang S. Corin K, et al. PLoS One. 2011;6(10):e23036. doi: 10.1371/journal.pone.0023036. Epub 2011 Oct 25. PLoS One. 2011. PMID: 22039398 Free PMC article.
Designer lipid-like peptides: a class of detergents for studying functional olfactory receptors using commercial cell-free systems.
Corin K, Baaske P, Ravel DB, Song J, Brown E, Wang X, Wienken CJ, Jerabek-Willemsen M, Duhr S, Luo Y, Braun D, Zhang S. Corin K, et al. PLoS One. 2011;6(11):e25067. doi: 10.1371/journal.pone.0025067. Epub 2011 Nov 23. PLoS One. 2011. PMID: 22132066 Free PMC article.
Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models.
Kim H, Xu H, George E, Hallberg D, Kumar S, Jagannathan V, Medvedev S, Kinose Y, Devins K, Verma P, Ly K, Wang Y, Greenberg RA, Schwartz L, Johnson N, Scharpf RB, Mills GB, Zhang R, Velculescu VE, Brown EJ, Simpkins F. Kim H, et al. Among authors: brown ej. Nat Commun. 2020 Jul 24;11(1):3726. doi: 10.1038/s41467-020-17127-2. Nat Commun. 2020. PMID: 32709856 Free PMC article.
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