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Identification of a novel allosteric GLP-1R antagonist HTL26119 using structure- based drug design.
O'Brien A, Andrews SP, Baig AH, Bortolato A, Brown AJH, Brown GA, Brown SH, Christopher JA, Congreve M, Cooke RM, De Graaf C, Errey JC, Fieldhouse C, Jazayeri A, Marshall FH, Mason JS, Mobarec JC, Okrasa K, Steele KN, Southall SM, Teobald I, Watson SP, Weir M. O'Brien A, et al. Among authors: Brown AJH, Brown GA, Brown SH. Bioorg Med Chem Lett. 2019 Oct 15;29(20):126611. doi: 10.1016/j.bmcl.2019.08.015. Epub 2019 Aug 9. Bioorg Med Chem Lett. 2019. PMID: 31447084
Targeting adenosine A2A receptor antagonism for treatment of cancer.
Congreve M, Brown GA, Borodovsky A, Lamb ML. Congreve M, et al. Among authors: Brown GA. Expert Opin Drug Discov. 2018 Nov;13(11):997-1003. doi: 10.1080/17460441.2018.1534825. Epub 2018 Oct 18. Expert Opin Drug Discov. 2018. PMID: 30336706 Review.
Structure-based and fragment-based GPCR drug discovery.
Andrews SP, Brown GA, Christopher JA. Andrews SP, et al. ChemMedChem. 2014 Feb;9(2):256-75. doi: 10.1002/cmdc.201300382. Epub 2013 Dec 18. ChemMedChem. 2014. PMID: 24353016 Review.
Structural insight into allosteric modulation of protease-activated receptor 2.
Cheng RKY, Fiez-Vandal C, Schlenker O, Edman K, Aggeler B, Brown DG, Brown GA, Cooke RM, Dumelin CE, Doré AS, Geschwindner S, Grebner C, Hermansson NO, Jazayeri A, Johansson P, Leong L, Prihandoko R, Rappas M, Soutter H, Snijder A, Sundström L, Tehan B, Thornton P, Troast D, Wiggin G, Zhukov A, Marshall FH, Dekker N. Cheng RKY, et al. Nature. 2017 May 4;545(7652):112-115. doi: 10.1038/nature22309. Epub 2017 Apr 26. Nature. 2017. PMID: 28445455
Agonists and Antagonists of Protease-Activated Receptor 2 Discovered within a DNA-Encoded Chemical Library Using Mutational Stabilization of the Target.
Brown DG, Brown GA, Centrella P, Certel K, Cooke RM, Cuozzo JW, Dekker N, Dumelin CE, Ferguson A, Fiez-Vandal C, Geschwindner S, Guié MA, Habeshian S, Keefe AD, Schlenker O, Sigel EA, Snijder A, Soutter HT, Sundström L, Troast DM, Wiggin G, Zhang J, Zhang Y, Clark MA. Brown DG, et al. SLAS Discov. 2018 Jun;23(5):429-436. doi: 10.1177/2472555217749847. Epub 2018 Jan 9. SLAS Discov. 2018. PMID: 29316408
Optimizing the role of androgen deprivation therapy in advanced prostate cancer: Challenges beyond the guidelines.
Shore ND, Antonarakis ES, Cookson MS, Crawford ED, Morgans AK, Albala DM, Hafron J, Harris RG, Saltzstein D, Brown GA, Henderson J, Lowentritt B, Spier JM, Concepcion R. Shore ND, et al. Among authors: Brown GA. Prostate. 2020 May;80(6):527-544. doi: 10.1002/pros.23967. Epub 2020 Mar 4. Prostate. 2020. PMID: 32130741 Free PMC article. Review.
Management of Surgical Site Infections.
Chen AF, Brown GA. Chen AF, et al. Among authors: Brown GA. J Am Acad Orthop Surg. 2020 Mar 15;28(6):e238-e241. doi: 10.5435/JAAOS-D-19-00552. J Am Acad Orthop Surg. 2020. PMID: 31725050
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