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The role of Rho in G protein-coupled receptor signal transduction.
Sah VP, Seasholtz TM, Sagi SA, Brown JH. Sah VP, et al. Among authors: brown jh. Annu Rev Pharmacol Toxicol. 2000;40:459-89. doi: 10.1146/annurev.pharmtox.40.1.459. Annu Rev Pharmacol Toxicol. 2000. PMID: 10836144 Review.
Yes-associated protein (YAP) mediates adaptive cardiac hypertrophy in response to pressure overload.
Byun J, Del Re DP, Zhai P, Ikeda S, Shirakabe A, Mizushima W, Miyamoto S, Brown JH, Sadoshima J. Byun J, et al. Among authors: brown jh. J Biol Chem. 2019 Mar 8;294(10):3603-3617. doi: 10.1074/jbc.RA118.006123. Epub 2019 Jan 11. J Biol Chem. 2019. PMID: 30635403 Free PMC article.
Identification of potential small molecule binding pockets on Rho family GTPases.
Ortiz-Sanchez JM, Nichols SE, Sayyah J, Brown JH, McCammon JA, Grant BJ. Ortiz-Sanchez JM, et al. Among authors: brown jh. PLoS One. 2012;7(7):e40809. doi: 10.1371/journal.pone.0040809. Epub 2012 Jul 16. PLoS One. 2012. PMID: 22815826 Free PMC article.
Selective coupling of the S1P3 receptor subtype to S1P-mediated RhoA activation and cardioprotection.
Yung BS, Brand CS, Xiang SY, Gray CB, Means CK, Rosen H, Chun J, Purcell NH, Brown JH, Miyamoto S. Yung BS, et al. Among authors: brown jh. J Mol Cell Cardiol. 2017 Feb;103:1-10. doi: 10.1016/j.yjmcc.2016.12.008. Epub 2016 Dec 23. J Mol Cell Cardiol. 2017. PMID: 28017639 Free PMC article.
Bitopic Sphingosine 1-Phosphate Receptor 3 (S1P3) Antagonist Rescue from Complete Heart Block: Pharmacological and Genetic Evidence for Direct S1P3 Regulation of Mouse Cardiac Conduction.
Sanna MG, Vincent KP, Repetto E, Nguyen N, Brown SJ, Abgaryan L, Riley SW, Leaf NB, Cahalan SM, Kiosses WB, Kohno Y, Brown JH, McCulloch AD, Rosen H, Gonzalez-Cabrera PJ. Sanna MG, et al. Among authors: brown sj, brown jh. Mol Pharmacol. 2016 Jan;89(1):176-86. doi: 10.1124/mol.115.100222. Epub 2015 Oct 22. Mol Pharmacol. 2016. PMID: 26494861 Free PMC article.
RhoA protects the mouse heart against ischemia/reperfusion injury.
Xiang SY, Vanhoutte D, Del Re DP, Purcell NH, Ling H, Banerjee I, Bossuyt J, Lang RA, Zheng Y, Matkovich SJ, Miyamoto S, Molkentin JD, Dorn GW 2nd, Brown JH. Xiang SY, et al. Among authors: brown jh. J Clin Invest. 2011 Aug;121(8):3269-76. doi: 10.1172/JCI44371. Epub 2011 Jul 11. J Clin Invest. 2011. PMID: 21747165 Free PMC article.
YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene expression, are critical for glioblastoma tumorigenicity.
Yu OM, Benitez JA, Plouffe SW, Ryback D, Klein A, Smith J, Greenbaum J, Delatte B, Rao A, Guan KL, Furnari FB, Chaim OM, Miyamoto S, Brown JH. Yu OM, et al. Among authors: brown jh. Oncogene. 2018 Oct;37(41):5492-5507. doi: 10.1038/s41388-018-0301-5. Epub 2018 Jun 11. Oncogene. 2018. PMID: 29887596 Free PMC article.
Myocardin-Related Transcription Factor A and Yes-Associated Protein Exert Dual Control in G Protein-Coupled Receptor- and RhoA-Mediated Transcriptional Regulation and Cell Proliferation.
Yu OM, Miyamoto S, Brown JH. Yu OM, et al. Among authors: brown jh. Mol Cell Biol. 2015 Oct 12;36(1):39-49. doi: 10.1128/MCB.00772-15. Print 2016 Jan 1. Mol Cell Biol. 2015. PMID: 26459764 Free PMC article.
G Protein-Coupled Receptor and RhoA-Stimulated Transcriptional Responses: Links to Inflammation, Differentiation, and Cell Proliferation.
Yu OM, Brown JH. Yu OM, et al. Among authors: brown jh. Mol Pharmacol. 2015 Jul;88(1):171-80. doi: 10.1124/mol.115.097857. Epub 2015 Apr 22. Mol Pharmacol. 2015. PMID: 25904553 Free PMC article. Review.
PLCĪµ mediated sustained signaling pathways.
Dusaban SS, Brown JH. Dusaban SS, et al. Among authors: brown jh. Adv Biol Regul. 2015 Jan;57:17-23. doi: 10.1016/j.jbior.2014.09.014. Epub 2014 Oct 5. Adv Biol Regul. 2015. PMID: 25453218 Free PMC article. Review.
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