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Exploiting tumour hypoxia in cancer treatment.
Brown JM, Wilson WR. Brown JM, et al. Nat Rev Cancer. 2004 Jun;4(6):437-47. doi: 10.1038/nrc1367. Nat Rev Cancer. 2004. PMID: 15170446 Review. No abstract available.
DNA cross-links in human tumor cells exposed to the prodrug PR-104A: relationships to hypoxia, bioreductive metabolism, and cytotoxicity.
Singleton RS, Guise CP, Ferry DM, Pullen SM, Dorie MJ, Brown JM, Patterson AV, Wilson WR. Singleton RS, et al. Cancer Res. 2009 May 1;69(9):3884-91. doi: 10.1158/0008-5472.CAN-08-4023. Epub 2009 Apr 14. Cancer Res. 2009. PMID: 19366798
Proceedings of the Oxygen Homeostasis/Hypoxia Meeting.
Kaufman B, Scharf O, Arbeit J, Ashcroft M, Brown JM, Bruick RK, Chapman JD, Evans SM, Giaccia AJ, Harris AL, Huang E, Johnson R, Kaelin W Jr, Koch CJ, Maxwell P, Mitchell J, Neckers L, Powis G, Rajendran J, Semenza GL, Simons J, Storkebaum E, Welch MJ, Whitelaw M, Melillo G, Ivy SP. Kaufman B, et al. Cancer Res. 2004 May 1;64(9):3350-6. doi: 10.1158/0008-5472.can-03-2611. Cancer Res. 2004. PMID: 15126380 No abstract available.
Homologous recombination is the principal pathway for the repair of DNA damage induced by tirapazamine in mammalian cells.
Evans JW, Chernikova SB, Kachnic LA, Banath JP, Sordet O, Delahoussaye YM, Treszezamsky A, Chon BH, Feng Z, Gu Y, Wilson WR, Pommier Y, Olive PL, Powell SN, Brown JM. Evans JW, et al. Cancer Res. 2008 Jan 1;68(1):257-65. doi: 10.1158/0008-5472.CAN-06-4497. Cancer Res. 2008. PMID: 18172318
Improved potency of the hypoxic cytotoxin tirapazamine by DNA-targeting.
Delahoussaye YM, Hay MP, Pruijn FB, Denny WA, Brown JM. Delahoussaye YM, et al. Biochem Pharmacol. 2003 Jun 1;65(11):1807-15. doi: 10.1016/s0006-2952(03)00199-0. Biochem Pharmacol. 2003. PMID: 12781332 Free PMC article.
Roles of DNA repair and reductase activity in the cytotoxicity of the hypoxia-activated dinitrobenzamide mustard PR-104A.
Gu Y, Patterson AV, Atwell GJ, Chernikova SB, Brown JM, Thompson LH, Wilson WR. Gu Y, et al. Mol Cancer Ther. 2009 Jun;8(6):1714-23. doi: 10.1158/1535-7163.MCT-08-1209. Epub 2009 Jun 9. Mol Cancer Ther. 2009. PMID: 19509245
Use of three-dimensional tissue cultures to model extravascular transport and predict in vivo activity of hypoxia-targeted anticancer drugs.
Hicks KO, Pruijn FB, Secomb TW, Hay MP, Hsu R, Brown JM, Denny WA, Dewhirst MW, Wilson WR. Hicks KO, et al. J Natl Cancer Inst. 2006 Aug 16;98(16):1118-28. doi: 10.1093/jnci/djj306. J Natl Cancer Inst. 2006. PMID: 16912264
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