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C13orf31 (FAMIN) is a central regulator of immunometabolic function.
Cader MZ, Boroviak K, Zhang Q, Assadi G, Kempster SL, Sewell GW, Saveljeva S, Ashcroft JW, Clare S, Mukhopadhyay S, Brown KP, Tschurtschenthaler M, Raine T, Doe B, Chilvers ER, Griffin JL, Kaneider NC, Floto RA, D'Amato M, Bradley A, Wakelam MJ, Dougan G, Kaser A. Cader MZ, et al. Among authors: brown kp. Nat Immunol. 2016 Sep;17(9):1046-56. doi: 10.1038/ni.3532. Epub 2016 Aug 1. Nat Immunol. 2016. PMID: 27478939 Free PMC article.
Azithromycin blocks autophagy and may predispose cystic fibrosis patients to mycobacterial infection.
Renna M, Schaffner C, Brown K, Shang S, Tamayo MH, Hegyi K, Grimsey NJ, Cusens D, Coulter S, Cooper J, Bowden AR, Newton SM, Kampmann B, Helm J, Jones A, Haworth CS, Basaraba RJ, DeGroote MA, Ordway DJ, Rubinsztein DC, Floto RA. Renna M, et al. Among authors: brown k. J Clin Invest. 2011 Sep;121(9):3554-63. doi: 10.1172/JCI46095. Epub 2011 Aug 1. J Clin Invest. 2011. PMID: 21804191 Free PMC article.
Functional drug screening reveals anticonvulsants as enhancers of mTOR-independent autophagic killing of Mycobacterium tuberculosis through inositol depletion.
Schiebler M, Brown K, Hegyi K, Newton SM, Renna M, Hepburn L, Klapholz C, Coulter S, Obregón-Henao A, Henao Tamayo M, Basaraba R, Kampmann B, Henry KM, Burgon J, Renshaw SA, Fleming A, Kay RR, Anderson KE, Hawkins PT, Ordway DJ, Rubinsztein DC, Floto RA. Schiebler M, et al. Among authors: brown k. EMBO Mol Med. 2015 Feb;7(2):127-39. doi: 10.15252/emmm.201404137. EMBO Mol Med. 2015. PMID: 25535254 Free PMC article.
Circulating platelet-neutrophil aggregates characterize the development of type 1 diabetes in humans and NOD mice.
Popp SK, Vecchio F, Brown DJ, Fukuda R, Suzuki Y, Takeda Y, Wakamatsu R, Sarma MA, Garrett J, Giovenzana A, Bosi E, Lafferty AR, Brown KJ, Gardiner EE, Coupland LA, Thomas HE, Chong BH, Parish CR, Battaglia M, Petrelli A, Simeonovic CJ. Popp SK, et al. Among authors: brown kj. JCI Insight. 2022 Jan 25;7(2):e153993. doi: 10.1172/jci.insight.153993. JCI Insight. 2022. PMID: 35076023
7,670 results