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Identification of luminal Loop 1 of Scap protein as the sterol sensor that maintains cholesterol homeostasis.
Motamed M, Zhang Y, Wang ML, Seemann J, Kwon HJ, Goldstein JL, Brown MS. Motamed M, et al. J Biol Chem. 2011 May 20;286(20):18002-12. doi: 10.1074/jbc.M111.238311. Epub 2011 Mar 24. J Biol Chem. 2011. PMID: 21454655 Free PMC article.
Identification of surface residues on Niemann-Pick C2 essential for hydrophobic handoff of cholesterol to NPC1 in lysosomes.
Wang ML, Motamed M, Infante RE, Abi-Mosleh L, Kwon HJ, Brown MS, Goldstein JL. Wang ML, et al. Cell Metab. 2010 Aug 4;12(2):166-73. doi: 10.1016/j.cmet.2010.05.016. Cell Metab. 2010. PMID: 20674861 Free PMC article.
The LDL receptor.
Goldstein JL, Brown MS. Goldstein JL, et al. Arterioscler Thromb Vasc Biol. 2009 Apr;29(4):431-8. doi: 10.1161/ATVBAHA.108.179564. Arterioscler Thromb Vasc Biol. 2009. PMID: 19299327 Free PMC article. Review.
Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL.
Brown MS, Goldstein JL. Brown MS, et al. J Lipid Res. 2009 Apr;50 Suppl(Suppl):S15-27. doi: 10.1194/jlr.R800054-JLR200. Epub 2008 Oct 29. J Lipid Res. 2009. PMID: 18974038 Free PMC article. Review.
Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol.
Sever N, Song BL, Yabe D, Goldstein JL, Brown MS, DeBose-Boyd RA. Sever N, et al. J Biol Chem. 2003 Dec 26;278(52):52479-90. doi: 10.1074/jbc.M310053200. Epub 2003 Oct 16. J Biol Chem. 2003. PMID: 14563840
Structure of the LDL receptor extracellular domain at endosomal pH.
Rudenko G, Henry L, Henderson K, Ichtchenko K, Brown MS, Goldstein JL, Deisenhofer J. Rudenko G, et al. Science. 2002 Dec 20;298(5602):2353-8. doi: 10.1126/science.1078124. Epub 2002 Nov 29. Science. 2002. PMID: 12459547
The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals.
Moon YA, Liang G, Xie X, Frank-Kamenetsky M, Fitzgerald K, Koteliansky V, Brown MS, Goldstein JL, Horton JD. Moon YA, et al. Cell Metab. 2012 Feb 8;15(2):240-6. doi: 10.1016/j.cmet.2011.12.017. Cell Metab. 2012. PMID: 22326225 Free PMC article.
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