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Curcumin decreases amyloid-beta peptide levels by attenuating the maturation of amyloid-beta precursor protein.
Zhang C, Browne A, Child D, Tanzi RE. Zhang C, et al. Among authors: browne a. J Biol Chem. 2010 Sep 10;285(37):28472-80. doi: 10.1074/jbc.M110.133520. Epub 2010 Jul 9. J Biol Chem. 2010. PMID: 20622013 Free PMC article.
Amyloid-β production via cleavage of amyloid-β protein precursor is modulated by cell density.
Zhang C, Browne A, Divito JR, Stevenson JA, Romano D, Dong Y, Xie Z, Tanzi RE. Zhang C, et al. Among authors: browne a. J Alzheimers Dis. 2010;22(2):683-984. doi: 10.3233/JAD-2010-100816. J Alzheimers Dis. 2010. PMID: 20847415 Free PMC article.
Loss of function of ATXN1 increases amyloid beta-protein levels by potentiating beta-secretase processing of beta-amyloid precursor protein.
Zhang C, Browne A, Child D, Divito JR, Stevenson JA, Tanzi RE. Zhang C, et al. Among authors: browne a. J Biol Chem. 2010 Mar 19;285(12):8515-26. doi: 10.1074/jbc.M109.079079. Epub 2010 Jan 22. J Biol Chem. 2010. PMID: 20097758 Free PMC article.
Familial Alzheimer's disease mutations in presenilin 1 do not alter levels of the secreted amyloid-beta protein precursor generated by beta-secretase cleavage.
Zhang C, Browne A, Kim DY, Tanzi RE. Zhang C, et al. Among authors: browne a. Curr Alzheimer Res. 2010 Feb;7(1):21-6. doi: 10.2174/156720510790274428. Curr Alzheimer Res. 2010. PMID: 20205669 Free PMC article.
Gene expression elucidates functional impact of polygenic risk for schizophrenia.
Fromer M, Roussos P, Sieberts SK, Johnson JS, Kavanagh DH, Perumal TM, Ruderfer DM, Oh EC, Topol A, Shah HR, Klei LL, Kramer R, Pinto D, Gümüş ZH, Cicek AE, Dang KK, Browne A, Lu C, Xie L, Readhead B, Stahl EA, Xiao J, Parvizi M, Hamamsy T, Fullard JF, Wang YC, Mahajan MC, Derry JM, Dudley JT, Hemby SE, Logsdon BA, Talbot K, Raj T, Bennett DA, De Jager PL, Zhu J, Zhang B, Sullivan PF, Chess A, Purcell SM, Shinobu LA, Mangravite LM, Toyoshiba H, Gur RE, Hahn CG, Lewis DA, Haroutunian V, Peters MA, Lipska BK, Buxbaum JD, Schadt EE, Hirai K, Roeder K, Brennand KJ, Katsanis N, Domenici E, Devlin B, Sklar P. Fromer M, et al. Among authors: browne a. Nat Neurosci. 2016 Nov;19(11):1442-1453. doi: 10.1038/nn.4399. Epub 2016 Sep 26. Nat Neurosci. 2016. PMID: 27668389 Free PMC article.
Genome-wide association study identifies candidate genes for Parkinson's disease in an Ashkenazi Jewish population.
Liu X, Cheng R, Verbitsky M, Kisselev S, Browne A, Mejia-Sanatana H, Louis ED, Cote LJ, Andrews H, Waters C, Ford B, Frucht S, Fahn S, Marder K, Clark LN, Lee JH. Liu X, et al. Among authors: browne a. BMC Med Genet. 2011 Aug 3;12:104. doi: 10.1186/1471-2350-12-104. BMC Med Genet. 2011. PMID: 21812969 Free PMC article.
Concurrent antitumor and bone-protective effects of everolimus in osteotropic breast cancer.
Browne AJ, Kubasch ML, Göbel A, Hadji P, Chen D, Rauner M, Stölzel F, Hofbauer LC, Rachner TD. Browne AJ, et al. Breast Cancer Res. 2017 Aug 9;19(1):92. doi: 10.1186/s13058-017-0885-7. Breast Cancer Res. 2017. PMID: 28793923 Free PMC article.
p38 MAPK regulates the Wnt inhibitor Dickkopf-1 in osteotropic prostate cancer cells.
Browne AJ, Göbel A, Thiele S, Hofbauer LC, Rauner M, Rachner TD. Browne AJ, et al. Cell Death Dis. 2016 Feb 25;7(2):e2119. doi: 10.1038/cddis.2016.32. Cell Death Dis. 2016. PMID: 26913608 Free PMC article.
Prognostic Value of RANKL/OPG Serum Levels and Disseminated Tumor Cells in Nonmetastatic Breast Cancer.
Rachner TD, Kasimir-Bauer S, Göbel A, Erdmann K, Hoffmann O, Browne A, Wimberger P, Rauner M, Hofbauer LC, Kimmig R, Bittner AK. Rachner TD, et al. Among authors: browne a. Clin Cancer Res. 2019 Feb 15;25(4):1369-1378. doi: 10.1158/1078-0432.CCR-18-2482. Epub 2018 Nov 13. Clin Cancer Res. 2019. PMID: 30425091
High serum levels of Dickkopf-1 are associated with a poor prognosis in prostate cancer patients.
Rachner TD, Thiele S, Göbel A, Browne A, Fuessel S, Erdmann K, Wirth MP, Fröhner M, Todenhöfer T, Muders MH, Kieslinger M, Rauner M, Hofbauer LC. Rachner TD, et al. Among authors: browne a. BMC Cancer. 2014 Sep 2;14:649. doi: 10.1186/1471-2407-14-649. BMC Cancer. 2014. PMID: 25182503 Free PMC article.
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