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T cell receptor signalling networks: branched, diversified and bounded.
Brownlie RJ, Zamoyska R. Brownlie RJ, et al. Nat Rev Immunol. 2013 Apr;13(4):257-69. doi: 10.1038/nri3403. Nat Rev Immunol. 2013. PMID: 23524462 Review.
LAT polices T cell activation.
Brownlie R, Zamoyska R. Brownlie R, et al. Immunity. 2009 Aug 21;31(2):174-6. doi: 10.1016/j.immuni.2009.08.002. Immunity. 2009. PMID: 19699166
FcgammaRIIb controls bone marrow plasma cell persistence and apoptosis.
Xiang Z, Cutler AJ, Brownlie RJ, Fairfax K, Lawlor KE, Severinson E, Walker EU, Manz RA, Tarlinton DM, Smith KG. Xiang Z, et al. Nat Immunol. 2007 Apr;8(4):419-29. doi: 10.1038/ni1440. Epub 2007 Feb 18. Nat Immunol. 2007. PMID: 17322888
Superresolution imaging of the cytoplasmic phosphatase PTPN22 links integrin-mediated T cell adhesion with autoimmunity.
Burn GL, Cornish GH, Potrzebowska K, Samuelsson M, Griffié J, Minoughan S, Yates M, Ashdown G, Pernodet N, Morrison VL, Sanchez-Blanco C, Purvis H, Clarke F, Brownlie RJ, Vyse TJ, Zamoyska R, Owen DM, Svensson LM, Cope AP. Burn GL, et al. Among authors: brownlie rj. Sci Signal. 2016 Oct 4;9(448):ra99. doi: 10.1126/scisignal.aaf2195. Sci Signal. 2016. PMID: 27703032
Mechanistic Target of Rapamycin Complex 1/S6 Kinase 1 Signals Influence T Cell Activation Independently of Ribosomal Protein S6 Phosphorylation.
Salmond RJ, Brownlie RJ, Meyuhas O, Zamoyska R. Salmond RJ, et al. Among authors: brownlie rj. J Immunol. 2015 Nov 15;195(10):4615-22. doi: 10.4049/jimmunol.1501473. Epub 2015 Oct 9. J Immunol. 2015. PMID: 26453749 Free PMC article.
Lack of the phosphatase PTPN22 increases adhesion of murine regulatory T cells to improve their immunosuppressive function.
Brownlie RJ, Miosge LA, Vassilakos D, Svensson LM, Cope A, Zamoyska R. Brownlie RJ, et al. Sci Signal. 2012 Nov 27;5(252):ra87. doi: 10.1126/scisignal.2003365. Sci Signal. 2012. PMID: 23193160 Free PMC article.
Loss of the Protein Tyrosine Phosphatase PTPN22 Reduces Mannan-Induced Autoimmune Arthritis in SKG Mice.
Sood S, Brownlie RJ, Garcia C, Cowan G, Salmond RJ, Sakaguchi S, Zamoyska R. Sood S, et al. Among authors: brownlie rj. J Immunol. 2016 Jul 15;197(2):429-40. doi: 10.4049/jimmunol.1502656. Epub 2016 Jun 10. J Immunol. 2016. PMID: 27288531 Free PMC article.
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