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On-demand drug delivery from local depots.
Brudno Y, Mooney DJ. Brudno Y, et al. J Control Release. 2015 Dec 10;219:8-17. doi: 10.1016/j.jconrel.2015.09.011. Epub 2015 Sep 14. J Control Release. 2015. PMID: 26374941 Review.
Scaffold-Mediated Static Transduction of T Cells for CAR-T Cell Therapy.
Agarwalla P, Ogunnaike EA, Ahn S, Ligler FS, Dotti G, Brudno Y. Agarwalla P, et al. Among authors: brudno y. Adv Healthc Mater. 2020 Jul;9(14):e2000275. doi: 10.1002/adhm.202000275. Epub 2020 Jun 11. Adv Healthc Mater. 2020. PMID: 32592454 Free PMC article.
Sustained delivery of VEGF maintains innervation and promotes reperfusion in ischemic skeletal muscles via NGF/GDNF signaling.
Shvartsman D, Storrie-White H, Lee K, Kearney C, Brudno Y, Ho N, Cezar C, McCann C, Anderson E, Koullias J, Tapia JC, Vandenburgh H, Lichtman JW, Mooney DJ. Shvartsman D, et al. Among authors: brudno y. Mol Ther. 2014 Jul;22(7):1243-1253. doi: 10.1038/mt.2014.76. Epub 2014 Apr 28. Mol Ther. 2014. PMID: 24769910 Free PMC article.
Refilling drug delivery depots through the blood.
Brudno Y, Silva EA, Kearney CJ, Lewin SA, Miller A, Martinick KD, Aizenberg M, Mooney DJ. Brudno Y, et al. Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12722-7. doi: 10.1073/pnas.1413027111. Epub 2014 Aug 19. Proc Natl Acad Sci U S A. 2014. PMID: 25139997 Free PMC article.
In vivo targeting through click chemistry.
Brudno Y, Desai RM, Kwee BJ, Joshi NS, Aizenberg M, Mooney DJ. Brudno Y, et al. ChemMedChem. 2015 Apr;10(4):617-20. doi: 10.1002/cmdc.201402527. Epub 2015 Feb 20. ChemMedChem. 2015. PMID: 25704998
Replenishable drug depot to combat post-resection cancer recurrence.
Brudno Y, Pezone MJ, Snyder TK, Uzun O, Moody CT, Aizenberg M, Mooney DJ. Brudno Y, et al. Biomaterials. 2018 Sep;178:373-382. doi: 10.1016/j.biomaterials.2018.05.005. Epub 2018 May 6. Biomaterials. 2018. PMID: 29779862 Free PMC article.
Regenerating Antithrombotic Surfaces through Nucleic Acid Displacement.
McNamara SL, Brudno Y, Miller AB, Ham HO, Aizenberg M, Chaikof EL, Mooney DJ. McNamara SL, et al. Among authors: brudno y. ACS Biomater Sci Eng. 2020 Apr 13;6(4):2159-2166. doi: 10.1021/acsbiomaterials.0c00038. Epub 2020 Mar 3. ACS Biomater Sci Eng. 2020. PMID: 33455325
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