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Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells.

Rezania A, Bruin JE, Arora P, Rubin A, Batushansky I, Asadi A, O'Dwyer S, Quiskamp N, Mojibian M, Albrecht T, Yang YH, Johnson JD, Kieffer TJ. Rezania A, et al. Among authors: bruin je. Nat Biotechnol. 2014 Nov;32(11):1121-33. doi: 10.1038/nbt.3033. Epub 2014 Sep 11. Nat Biotechnol. 2014. PMID: 25211370

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Maturation of human embryonic stem cell-derived pancreatic progenitors into functional islets capable of treating pre-existing diabetes in mice.

Rezania A, Bruin JE, Riedel MJ, Mojibian M, Asadi A, Xu J, Gauvin R, Narayan K, Karanu F, O'Neil JJ, Ao Z, Warnock GL, Kieffer TJ. Rezania A, et al. Among authors: bruin je. Diabetes. 2012 Aug;61(8):2016-29. doi: 10.2337/db11-1711. Epub 2012 Jun 27. Diabetes. 2012. PMID: 22740171 Free PMC article.

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Restoring insulin production for type 1 diabetes.

Tudurí E, Bruin JE, Kieffer TJ. Tudurí E, et al. Among authors: bruin je. J Diabetes. 2012 Dec;4(4):319-31. doi: 10.1111/j.1753-0407.2012.00196.x. J Diabetes. 2012. PMID: 22429761 Review.

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Deletion of pancreas-specific miR-216a reduces beta-cell mass and inhibits pancreatic cancer progression in mice.

Erener S, Ellis CE, Ramzy A, Glavas MM, O'Dwyer S, Pereira S, Wang T, Pang J, Bruin JE, Riedel MJ, Baker RK, Webber TD, Lesina M, Blüher M, Algül H, Kopp JL, Herzig S, Kieffer TJ. Erener S, et al. Among authors: bruin je. Cell Rep Med. 2021 Nov 11;2(11):100434. doi: 10.1016/j.xcrm.2021.100434. eCollection 2021 Nov 16. Cell Rep Med. 2021. PMID: 34841287 Free PMC article.

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Differentiation of human pluripotent stem cells into β-cells: Potential and challenges.

Quiskamp N, Bruin JE, Kieffer TJ. Quiskamp N, et al. Among authors: bruin je. Best Pract Res Clin Endocrinol Metab. 2015 Dec;29(6):833-47. doi: 10.1016/j.beem.2015.10.011. Epub 2015 Oct 30. Best Pract Res Clin Endocrinol Metab. 2015. PMID: 26696513 Review.

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Human Pluripotent Stem Cells: A Unique Tool for Toxicity Testing in Pancreatic Progenitor and Endocrine Cells.

MacFarlane EM, Bruin JE. MacFarlane EM, et al. Among authors: bruin je. Front Endocrinol (Lausanne). 2021 Jan 19;11:604998. doi: 10.3389/fendo.2020.604998. eCollection 2020. Front Endocrinol (Lausanne). 2021. PMID: 33542706 Free PMC article.

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Long-term consequences of fetal and neonatal nicotine exposure: a critical review.

Bruin JE, Gerstein HC, Holloway AC. Bruin JE, et al. Toxicol Sci. 2010 Aug;116(2):364-74. doi: 10.1093/toxsci/kfq103. Epub 2010 Apr 2. Toxicol Sci. 2010. PMID: 20363831 Free PMC article. Review.

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Prolonged Low-Dose Dioxin Exposure Impairs Metabolic Adaptability to High-Fat Diet Feeding in Female but Not Male Mice.

Matteo G, Hoyeck MP, Blair HL, Zebarth J, Rick KRC, Williams A, Gagné R, Buick JK, Yauk CL, Bruin JE. Matteo G, et al. Among authors: bruin je. Endocrinology. 2021 Jun 1;162(6):bqab050. doi: 10.1210/endocr/bqab050. Endocrinology. 2021. PMID: 33693622 Free PMC article.

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Persistent organic pollutants and β-cell toxicity: a comprehensive review.

Hoyeck MP, Matteo G, MacFarlane EM, Perera I, Bruin JE. Hoyeck MP, et al. Among authors: bruin je. Am J Physiol Endocrinol Metab. 2022 May 1;322(5):E383-E413. doi: 10.1152/ajpendo.00358.2021. Epub 2022 Feb 14. Am J Physiol Endocrinol Metab. 2022. PMID: 35156417 Free PMC article. Review.

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Long-term metabolic consequences of acute dioxin exposure differ between male and female mice.

Hoyeck MP, Blair H, Ibrahim M, Solanki S, Elsawy M, Prakash A, Rick KRC, Matteo G, O'Dwyer S, Bruin JE. Hoyeck MP, et al. Among authors: bruin je. Sci Rep. 2020 Jan 29;10(1):1448. doi: 10.1038/s41598-020-57973-0. Sci Rep. 2020. PMID: 31996693 Free PMC article.

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