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Function, regulation and pathological roles of the Gab/DOS docking proteins.
Wöhrle FU, Daly RJ, Brummer T. Wöhrle FU, et al. Among authors: brummer t. Cell Commun Signal. 2009 Sep 8;7:22. doi: 10.1186/1478-811X-7-22. Cell Commun Signal. 2009. PMID: 19737390 Free PMC article.
Gab2 is Essential for Transformation by FLT3-ITD in Acute Myeloid Leukemia.
Sies K, Spohr C, Gründer A, Todorova R, Uhl FM, Huber J, Zeiser R, Pahl HL, Becker H, Aumann K, Brummer T, Halbach S. Sies K, et al. Among authors: brummer t. Hemasphere. 2019 Feb 22;3(2):e184. doi: 10.1097/HS9.0000000000000184. eCollection 2019 Apr. Hemasphere. 2019. PMID: 31723823 Free PMC article. No abstract available.
How to Grb2 a Gab.
Wöhrle FU, Daly RJ, Brummer T. Wöhrle FU, et al. Among authors: brummer t. Structure. 2009 Jun 10;17(6):779-81. doi: 10.1016/j.str.2009.05.003. Structure. 2009. PMID: 19523893
Docking proteins.
Brummer T, Schmitz-Peiffer C, Daly RJ. Brummer T, et al. FEBS J. 2010 Nov;277(21):4356-69. doi: 10.1111/j.1742-4658.2010.07865.x. Epub 2010 Sep 30. FEBS J. 2010. PMID: 20883498 Review.
The immunohistochemical staining pattern of Gab2 correlates with distinct stages of chronic myeloid leukemia.
Aumann K, Lassmann S, Schöpflin A, May AM, Wöhrle FU, Zeiser R, Waller CF, Hauschke D, Werner M, Brummer T. Aumann K, et al. Among authors: brummer t. Hum Pathol. 2011 May;42(5):719-26. doi: 10.1016/j.humpath.2010.09.012. Epub 2011 Feb 2. Hum Pathol. 2011. PMID: 21292300
Chronic myeloid leukemia cells with t(9;22)(q34;q11) express the Bcr/Abl fusion protein, which interacts with Grb2 and Gab2 signaling, thereby triggering hematopoietic cell proliferation. ...
Chronic myeloid leukemia cells with t(9;22)(q34;q11) express the Bcr/Abl fusion protein, which interacts with Grb2 and Gab2 signaling …
A novel MCF-10A line allowing conditional oncogene expression in 3D culture.
Herr R, Wöhrle FU, Danke C, Berens C, Brummer T. Herr R, et al. Among authors: brummer t. Cell Commun Signal. 2011 Jul 13;9:17. doi: 10.1186/1478-811X-9-17. Cell Commun Signal. 2011. PMID: 21752278 Free PMC article.
Aberrant B-Raf signaling in human cancer -- 10 years from bench to bedside.
Röring M, Brummer T. Röring M, et al. Among authors: brummer t. Crit Rev Oncog. 2012;17(1):97-121. doi: 10.1615/critrevoncog.v17.i1.70. Crit Rev Oncog. 2012. PMID: 22471666 Review.
Gab2 signaling in chronic myeloid leukemia cells confers resistance to multiple Bcr-Abl inhibitors.
Wöhrle FU, Halbach S, Aumann K, Schwemmers S, Braun S, Auberger P, Schramek D, Penninger JM, Laßmann S, Werner M, Waller CF, Pahl HL, Zeiser R, Daly RJ, Brummer T. Wöhrle FU, et al. Among authors: brummer t. Leukemia. 2013 Jan;27(1):118-29. doi: 10.1038/leu.2012.222. Epub 2012 Aug 3. Leukemia. 2013. PMID: 22858987
Alterations of Gab2 signalling complexes in imatinib and dasatinib treated chronic myeloid leukaemia cells.
Halbach S, Rigbolt KT, Wöhrle FU, Diedrich B, Gretzmeier C, Brummer T, Dengjel J. Halbach S, et al. Among authors: brummer t. Cell Commun Signal. 2013 Apr 22;11(1):30. doi: 10.1186/1478-811X-11-30. Cell Commun Signal. 2013. PMID: 23607741 Free PMC article.
Differential tyrosine phosphorylation controls the function of CNK1 as a molecular switch in signal transduction.
Fischer A, Brummer T, Warscheid B, Radziwill G. Fischer A, et al. Among authors: brummer t. Biochim Biophys Acta. 2015 Nov;1853(11 Pt A):2847-55. doi: 10.1016/j.bbamcr.2015.08.014. Epub 2015 Aug 28. Biochim Biophys Acta. 2015. PMID: 26319181
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