Brunck TK - Search Results

1

Guanylpiperidine peptidomimetics: potent and selective bis-cation inhibitors of factor Xa.

Tamura SY, Levy OE, Uong TH, Reiner JE, Goldman EA, Ho JZ, Cohen CR, Bergum PW, Nutt RF, Brunck TK, Semple JE. Tamura SY, et al. Among authors: brunck tk. Bioorg Med Chem Lett. 2000 Apr 17;10(8):745-9. doi: 10.1016/s0960-894x(00)00105-0. Bioorg Med Chem Lett. 2000. PMID: 10782677

2

Highly selective mechanism-based thrombin inhibitors: structures of thrombin and trypsin inhibited with rigid peptidyl aldehydes.

Krishnan R, Zhang E, Hakansson K, Arni RK, Tulinsky A, Lim-Wilby MS, Levy OE, Semple JE, Brunck TK. Krishnan R, et al. Among authors: brunck tk. Biochemistry. 1998 Sep 1;37(35):12094-103. doi: 10.1021/bi980840e. Biochemistry. 1998. PMID: 9724521

3

Potent and selective thrombin inhibitors featuring hydrophobic, basic P3-P4-aminoalkyllactam moieties.

Semple JE, Rowley DC, Owens TD, Minami NK, Uong TH, Brunck TK. Semple JE, et al. Among authors: brunck tk. Bioorg Med Chem Lett. 1998 Dec 15;8(24):3525-30. doi: 10.1016/s0960-894x(98)00636-2. Bioorg Med Chem Lett. 1998. PMID: 9934465

4

Investigation of the S3 site of thrombin: design, synthesis and biological activity of 4-substituted 3-amino-2-pyridones incorporating P1-argininals.

Reiner JE, Lim-Wilby MS, Brunck TK, Ha-Uong T, Goldman EA, Abelman MA, Nutt RF, Semple JE, Tamura SY. Reiner JE, et al. Among authors: brunck tk. Bioorg Med Chem Lett. 1999 Mar 22;9(6):895-900. doi: 10.1016/s0960-894x(99)00102-x. Bioorg Med Chem Lett. 1999. PMID: 10206557

5

Synthesis and biological activity of peptidyl aldehyde urokinase inhibitors.

Tamura SY, Weinhouse MI, Roberts CA, Goldman EA, Masukawa K, Anderson SM, Cohen CR, Bradbury AE, Bernardino VT, Dixon SA, Ma MG, Nolan TG, Brunck TK. Tamura SY, et al. Among authors: brunck tk. Bioorg Med Chem Lett. 2000 May 1;10(9):983-7. doi: 10.1016/s0960-894x(00)00149-9. Bioorg Med Chem Lett. 2000. PMID: 10853674

6

Design, synthesis, and evolution of a novel, selective, and orally bioavailable class of thrombin inhibitors: P1-argininal derivatives incorporating P3-P4 lactam sulfonamide moieties.

Semple JE, Rowley DC, Brunck TK, Ha-Uong T, Minami NK, Owens TD, Tamura SY, Goldman EA, Siev DV, Ardecky RJ, Carpenter SH, Ge Y, Richard BM, Nolan TG, Håkanson K, Tulinsky A, Nutt RF, Ripka WC. Semple JE, et al. Among authors: brunck tk. J Med Chem. 1996 Nov 8;39(23):4531-6. doi: 10.1021/jm960572n. J Med Chem. 1996. PMID: 8917639 No abstract available.

7

Crystallographic structure of a peptidyl keto acid inhibitor and human alpha-thrombin.

Håkansson K, Tulinsky A, Abelman MM, Miller TA, Vlasuk GP, Bergum PW, Lim-Wilby MS, Brunck TK. Håkansson K, et al. Among authors: brunck tk. Bioorg Med Chem. 1995 Aug;3(8):1009-17. doi: 10.1016/0968-0896(95)00096-y. Bioorg Med Chem. 1995. PMID: 7582975

8

Synthesis, structure, and structure-activity relationships of divalent thrombin inhibitors containing an alpha-keto-amide transition-state mimetic.

Krishnan R, Tulinsky A, Vlasuk GP, Pearson D, Vallar P, Bergum P, Brunck TK, Ripka WC. Krishnan R, et al. Among authors: brunck tk. Protein Sci. 1996 Mar;5(3):422-33. doi: 10.1002/pro.5560050303. Protein Sci. 1996. PMID: 8868478 Free PMC article.

9

NMR structure determination of tick anticoagulant peptide (TAP).

Lim-Wilby MS, Hallenga K, de Maeyer M, Lasters I, Vlasuk GP, Brunck TK. Lim-Wilby MS, et al. Among authors: brunck tk. Protein Sci. 1995 Feb;4(2):178-86. doi: 10.1002/pro.5560040205. Protein Sci. 1995. PMID: 7538849 Free PMC article.

10

Antisense peptide recognition of sense peptides: sequence simplification and evaluation of forces underlying the interaction.

Shai Y, Brunck TK, Chaiken IM. Shai Y, et al. Among authors: brunck tk. Biochemistry. 1989 Oct 31;28(22):8804-11. doi: 10.1021/bi00448a019. Biochemistry. 1989. PMID: 2605221

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