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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1948 1
1966 1
1969 3
1970 3
1971 4
1972 1
1973 5
1974 8
1975 2
1976 5
1977 6
1978 6
1979 6
1980 10
1981 5
1982 3
1983 7
1984 2
1985 6
1986 12
1987 7
1988 7
1989 9
1990 15
1991 14
1992 13
1993 15
1994 19
1995 12
1996 11
1997 14
1998 11
1999 10
2000 24
2001 19
2002 19
2003 16
2004 21
2005 16
2006 19
2007 25
2008 11
2009 16
2010 12
2011 5
2012 4
2013 3
2014 5
2015 6
2016 3
2017 4
2018 1
2019 1
2020 0
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470 results
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Page 1
Acetaminophen/paracetamol: A history of errors, failures and false decisions
Brune K, et al. Eur J Pain 2015 - Review. PMID 25429980
Further information is found in earlier reviews by Eichengrün, Rodnan and Benedek, Sneader, Brune; comp. references. The history of the discovery of paracetamol starts with an error (active against worms), continues with a false assumption (paracetamol is safer than phenacetin), describes the first side-effect 'epidemy' (phenacetin nephropathy, drug-induced interstitial nephritis) and ends with the discovery of second-generation problems due to the unavoidable production of a highly toxic metabolite of paracetamol N-acetyl-p-benzoquinone imine (NAPQI) that may cause not only ALF and kidney damage but also impaired development of the fetus and the newborn child. ...
Further information is found in earlier reviews by Eichengrün, Rodnan and Benedek, Sneader, Brune; comp. references. The history of t …
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