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FOXO transcription factors at the interface between longevity and tumor suppression.
Greer EL, Brunet A. Greer EL, et al. Oncogene. 2005 Nov 14;24(50):7410-25. doi: 10.1038/sj.onc.1209086. Oncogene. 2005. PMID: 16288288 Review.
A wide range of human diseases, including cancer, has a striking age-dependent onset. However, the molecular mechanisms that connect aging and cancer are just beginning to be unraveled. ...Emerging evidence also suggests that FOXO factors play a tumor suppres
A wide range of human diseases, including cancer, has a striking age-dependent onset. However, the molecular mechanisms that c
The many forks in FOXO's road.
Tran H, Brunet A, Griffith EC, Greenberg ME. Tran H, et al. Sci STKE. 2003 Mar 4;2003(172):RE5. doi: 10.1126/stke.2003.172.re5. Sci STKE. 2003. PMID: 12621150 Review.
Building upon work in the nematode, researchers have uncovered a role for these proteins in a diverse set of cellular responses that include glucose metabolism, stress response, cell cycle regulation, and apoptosis. ...A number of studies have also shed light …
Building upon work in the nematode, researchers have uncovered a role for these proteins in a diverse set of cellular response …
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase.
Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY, Hu LS, Cheng HL, Jedrychowski MP, Gygi SP, Sinclair DA, Alt FW, Greenberg ME. Brunet A, et al. Science. 2004 Mar 26;303(5666):2011-5. doi: 10.1126/science.1094637. Epub 2004 Feb 19. Science. 2004. PMID: 14976264
SIRT1 and the FOXO transcription factor FOXO3 formed a complex in cells in response to oxidative stress, and SIRT1 deacetylated FOXO3 in vitro and within cells. SIRT1 had a dual effect on FOXO3 function: SIRT1 increased FOXO3's ability to induce cell cycle arrest an …
SIRT1 and the FOXO transcription factor FOXO3 formed a complex in cells in response to oxidative stress, and SIRT1 deacetylated FOXO3 …
FOXO transcription factors.
Carter ME, Brunet A. Carter ME, et al. Curr Biol. 2007 Feb 20;17(4):R113-4. doi: 10.1016/j.cub.2007.01.008. Curr Biol. 2007. PMID: 17307039 No abstract available.
The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor.
Greer EL, Oskoui PR, Banko MR, Maniar JM, Gygi MP, Gygi SP, Brunet A. Greer EL, et al. J Biol Chem. 2007 Oct 12;282(41):30107-19. doi: 10.1074/jbc.M705325200. Epub 2007 Aug 20. J Biol Chem. 2007. PMID: 17711846
Using a genome-wide microarray analysis, we identify a set of target genes that are regulated by FOXO3 when phosphorylated at these six regulatory sites in mammalian cells. The regulation of FOXO3 by AMPK may play a crucial role in fine tuning gene expression …
Using a genome-wide microarray analysis, we identify a set of target genes that are regulated by FOXO3 when phosphorylated at …
An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans.
Greer EL, Dowlatshahi D, Banko MR, Villen J, Hoang K, Blanchard D, Gygi SP, Brunet A. Greer EL, et al. Curr Biol. 2007 Oct 9;17(19):1646-56. doi: 10.1016/j.cub.2007.08.047. Epub 2007 Sep 27. Curr Biol. 2007. PMID: 17900900 Free PMC article.
BACKGROUND: Dietary restriction (DR) is the most effective environmental intervention to extend lifespan in a wide range of species. ...Expression of an active version of AMPK in worms increases stress resistance and extends longevity in a FOXO/DAF-16-dependent mann …
BACKGROUND: Dietary restriction (DR) is the most effective environmental intervention to extend lifespan in a wide range of species. …
FOXO transcription factors in ageing and cancer.
Greer EL, Brunet A. Greer EL, et al. Acta Physiol (Oxf). 2008 Jan;192(1):19-28. doi: 10.1111/j.1748-1716.2007.01780.x. Acta Physiol (Oxf). 2008. PMID: 18171426 Review.
In the absence of insulin/growth factors, FOXO factors translocate to the nucleus where they trigger a range of cellular responses, including resistance to oxidative stress, a phenotype highly coupled with lifespan extension. FOXO factors integrate stress stimuli vi …
In the absence of insulin/growth factors, FOXO factors translocate to the nucleus where they trigger a range of cellular responses, i …
Signaling networks in aging.
Greer EL, Brunet A. Greer EL, et al. J Cell Sci. 2008 Feb 15;121(Pt 4):407-12. doi: 10.1242/jcs.021519. J Cell Sci. 2008. PMID: 18256383 Review. No abstract available.
The FoxO code.
Calnan DR, Brunet A. Calnan DR, et al. Oncogene. 2008 Apr 7;27(16):2276-88. doi: 10.1038/onc.2008.21. Oncogene. 2008. PMID: 18391970 Review.
FoxO transcription factors translate a variety of environmental stimuli, including insulin, growth factors, nutrients and oxidative stress, into specific gene-expression programs. ...An intriguing possibility is that FoxO PTMs may act as a 'molecular FoxO code' read …
FoxO transcription factors translate a variety of environmental stimuli, including insulin, growth factors, nutrients and oxidative s …
FoxO transcription factors in the maintenance of cellular homeostasis during aging.
Salih DA, Brunet A. Salih DA, et al. Curr Opin Cell Biol. 2008 Apr;20(2):126-36. doi: 10.1016/j.ceb.2008.02.005. Epub 2008 Apr 3. Curr Opin Cell Biol. 2008. PMID: 18394876 Free PMC article. Review.
FoxO factors are key downstream targets of insulin, growth factor, nutrient, and oxidative stress stimuli that coordinate a wide range of cellular outputs. ...This review will discuss the roles of the mammalian FoxO family in a variety of cell types, from stem cells …
FoxO factors are key downstream targets of insulin, growth factor, nutrient, and oxidative stress stimuli that coordinate a wide rang …
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