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Oral treatment with PD-0200347, an alpha2delta ligand, reduces the development of experimental osteoarthritis by inhibiting metalloproteinases and inducible nitric oxide synthase gene expression and synthesis in cartilage chondrocytes.
Boileau C, Martel-Pelletier J, Brunet J, Tardif G, Schrier D, Flory C, El-Kattan A, Boily M, Pelletier JP. Boileau C, et al. Among authors: brunet j. Arthritis Rheum. 2005 Feb;52(2):488-500. doi: 10.1002/art.20809. Arthritis Rheum. 2005. PMID: 15693013 Free article.
The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases.
Pelletier JP, Boileau C, Boily M, Brunet J, Mineau F, Geng C, Reboul P, Laufer S, Lajeunesse D, Martel-Pelletier J. Pelletier JP, et al. Among authors: brunet j. Arthritis Res Ther. 2005;7(5):R1091-102. doi: 10.1186/ar1788. Epub 2005 Jul 19. Arthritis Res Ther. 2005. PMID: 16207326 Free PMC article.
1,061 results