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53 results
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Human variants in the neuronal basic helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) transcription factor complex NPAS4/ARNT2 disrupt function.
Bersten DC, Bruning JB, Peet DJ, Whitelaw ML. Bersten DC, et al. Among authors: bruning jb. PLoS One. 2014 Jan 17;9(1):e85768. doi: 10.1371/journal.pone.0085768. eCollection 2014. PLoS One. 2014. PMID: 24465693 Free PMC article.
Rare variants in single-minded 1 (SIM1) are associated with severe obesity.
Ramachandrappa S, Raimondo A, Cali AM, Keogh JM, Henning E, Saeed S, Thompson A, Garg S, Bochukova EG, Brage S, Trowse V, Wheeler E, Sullivan AE, Dattani M, Clayton PE, Datta V, Bruning JB, Wareham NJ, O'Rahilly S, Peet DJ, Barroso I, Whitelaw ML, Farooqi IS. Ramachandrappa S, et al. Among authors: bruning jb. J Clin Invest. 2013 Jul;123(7):3042-50. doi: 10.1172/JCI68016. Epub 2013 Jun 17. J Clin Invest. 2013. PMID: 23778139 Free PMC article.
Characterization of human variants in obesity-related SIM1 protein identifies a hot-spot for dimerization with the partner protein ARNT2.
Sullivan AE, Raimondo A, Schwab TA, Bruning JB, Froguel P, Farooqi IS, Peet DJ, Whitelaw ML. Sullivan AE, et al. Among authors: bruning jb. Biochem J. 2014 Aug 1;461(3):403-12. doi: 10.1042/BJ20131618. Biochem J. 2014. PMID: 24814368
p21 Exploits Residue Tyr151 as a Tether for High-Affinity PCNA Binding.
Kroker AJ, Bruning JB. Kroker AJ, et al. Among authors: bruning jb. Biochemistry. 2015 Jun 9;54(22):3483-93. doi: 10.1021/acs.biochem.5b00241. Epub 2015 May 27. Biochemistry. 2015. PMID: 25972089
Structural mechanism for signal transduction in RXR nuclear receptor heterodimers.
Kojetin DJ, Matta-Camacho E, Hughes TS, Srinivasan S, Nwachukwu JC, Cavett V, Nowak J, Chalmers MJ, Marciano DP, Kamenecka TM, Shulman AI, Rance M, Griffin PR, Bruning JB, Nettles KW. Kojetin DJ, et al. Among authors: bruning jb. Nat Commun. 2015 Aug 20;6:8013. doi: 10.1038/ncomms9013. Nat Commun. 2015. PMID: 26289479 Free PMC article.
Loss-of-function mutations in SIM1 contribute to obesity and Prader-Willi-like features.
Bonnefond A, Raimondo A, Stutzmann F, Ghoussaini M, Ramachandrappa S, Bersten DC, Durand E, Vatin V, Balkau B, Lantieri O, Raverdy V, Pattou F, Van Hul W, Van Gaal L, Peet DJ, Weill J, Miller JL, Horber F, Goldstone AP, Driscoll DJ, Bruning JB, Meyre D, Whitelaw ML, Froguel P. Bonnefond A, et al. Among authors: bruning jb. J Clin Invest. 2013 Jul;123(7):3037-41. doi: 10.1172/JCI68035. Epub 2013 Jun 17. J Clin Invest. 2013. PMID: 23778136 Free PMC article.
Expressing a moth abcc2 gene in transgenic Drosophila causes susceptibility to Bt Cry1Ac without requiring a cadherin-like protein receptor.
Stevens T, Song S, Bruning JB, Choo A, Baxter SW. Stevens T, et al. Among authors: bruning jb. Insect Biochem Mol Biol. 2017 Jan;80:61-70. doi: 10.1016/j.ibmb.2016.11.008. Epub 2016 Nov 30. Insect Biochem Mol Biol. 2017. PMID: 27914919
Structure of the sliding clamp from the fungal pathogen Aspergillus fumigatus (AfumPCNA) and interactions with Human p21.
Marshall AC, Kroker AJ, Murray LA, Gronthos K, Rajapaksha H, Wegener KL, Bruning JB. Marshall AC, et al. Among authors: bruning jb. FEBS J. 2017 Mar;284(6):985-1002. doi: 10.1111/febs.14035. Epub 2017 Feb 27. FEBS J. 2017. PMID: 28165677
Mechanisms Governing Precise Protein Biotinylation.
Sternicki LM, Wegener KL, Bruning JB, Booker GW, Polyak SW. Sternicki LM, et al. Among authors: bruning jb. Trends Biochem Sci. 2017 May;42(5):383-394. doi: 10.1016/j.tibs.2017.02.001. Epub 2017 Mar 3. Trends Biochem Sci. 2017. PMID: 28268045 Review.
Structural and functional characterisation of the cytochrome P450 enzyme CYP268A2 from Mycobacterium marinum.
Child SA, Naumann EF, Bruning JB, Bell SG. Child SA, et al. Among authors: bruning jb. Biochem J. 2018 Feb 16;475(4):705-722. doi: 10.1042/BCJ20170946. Biochem J. 2018. PMID: 29343612
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