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Inhibitors of cyclic AMP phosphodiesterase. 3. Synthesis and biological evaluation of pyrido and imidazolyl analogues of 1,2,3,5-tetrahydro-2-oxoimidazo[2,1-b]quinazoline.
Venuti MC, Stephenson RA, Alvarez R, Bruno JJ, Strosberg AM. Venuti MC, et al. Among authors: bruno jj. J Med Chem. 1988 Nov;31(11):2136-45. doi: 10.1021/jm00119a014. J Med Chem. 1988. PMID: 2846839
Inhibitors of cyclic AMP phosphodiesterase. 4. Synthesis and evaluation of potential prodrugs of lixazinone (N-cyclohexyl-N-methyl-4-[(1,2,3,5-tetrahydro-2- oxoimidazo[2,1-b]quinazolin-7-yl)-oxy]butyramide, RS-82856).
Venuti MC, Alvarez R, Bruno JJ, Strosberg AM, Gu L, Chiang HS, Massey IJ, Chu N, Fried JH. Venuti MC, et al. Among authors: bruno jj. J Med Chem. 1988 Nov;31(11):2145-52. doi: 10.1021/jm00119a015. J Med Chem. 1988. PMID: 2846840
Effects of enprostil on cardiovascular and respiratory parameters in the dog, and on hematologic parameters in the rat, monkey, and human.
Johnson LG, Bruno JJ, Allely MC, Eglen RM, Chang K, Yang D, Alps BJ, Rosenkranz RP, Strosberg AM. Johnson LG, et al. Among authors: bruno jj. Arzneimittelforschung. 1989 Nov;39(11):1443-8. Arzneimittelforschung. 1989. PMID: 2515862
Stimulation of prostaglandin D2 receptors on human platelets by analogs of prostacyclin.
Alvarez R, Eglen RM, Chang LF, Bruno JJ, Artis DR, Kluge AF, Whiting RL. Alvarez R, et al. Among authors: bruno jj. Prostaglandins. 1991 Aug;42(2):105-19. doi: 10.1016/0090-6980(91)90070-v. Prostaglandins. 1991. PMID: 1775633
Inhibitors of cyclic AMP phosphodiesterase. 2. Structural variations of N-cyclohexyl-N-methyl-4-[(1,2,3,5-tetrahydro- 2-oxoimidazo[2,1-b]quinazolin-7-yl)-oxy]butyramide (RS-82856).
Venuti MC, Jones GH, Alvarez R, Bruno JJ. Venuti MC, et al. Among authors: bruno jj. J Med Chem. 1987 Feb;30(2):303-18. doi: 10.1021/jm00385a012. J Med Chem. 1987. PMID: 3027339
Inhibitors of cyclic AMP phosphodiesterase. 1. Analogues of cilostamide and anagrelide.
Jones GH, Venuti MC, Alvarez R, Bruno JJ, Berks AH, Prince A. Jones GH, et al. Among authors: bruno jj. J Med Chem. 1987 Feb;30(2):295-303. doi: 10.1021/jm00385a011. J Med Chem. 1987. PMID: 3027338
Synthesis and platelet aggregation inhibition activity of a series of enantiomeric bicyclo[3.2.0]heptane-6-oximinoacetic acids (1).
O-Yang C, Kertesz DJ, Kluge AF, Kuenzler P, Li TT, Marx MM, Bruno JJ, Chang LF. O-Yang C, et al. Among authors: bruno jj. Prostaglandins. 1984 Jun;27(6):851-63. doi: 10.1016/s0090-6980(84)80005-2. Prostaglandins. 1984. PMID: 6484210
RS-82856, a selective phosphodiesterase inhibitor with inotropic, afterload reduction and antithrombotic properties.
Strosberg AM, Johnson L, Montgomery W, Lee CH, Alvarez R, Bruno JJ, Jones GH, Venuti MC. Strosberg AM, et al. Among authors: bruno jj. Proc West Pharmacol Soc. 1987;30:5-10. Proc West Pharmacol Soc. 1987. PMID: 3628319 No abstract available.
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