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Phosphorylation of TRIM28 Enhances the Expression of IFN-β and Proinflammatory Cytokines During HPAIV Infection of Human Lung Epithelial Cells.
Krischuns T, Günl F, Henschel L, Binder M, Willemsen J, Schloer S, Rescher U, Gerlt V, Zimmer G, Nordhoff C, Ludwig S, Brunotte L. Krischuns T, et al. Among authors: brunotte l. Front Immunol. 2018 Sep 28;9:2229. doi: 10.3389/fimmu.2018.02229. eCollection 2018. Front Immunol. 2018. PMID: 30323812 Free PMC article.
The annexin A1/FPR2 signaling axis expands alveolar macrophages, limits viral replication, and attenuates pathogenesis in the murine influenza A virus infection model.
Schloer S, Hübel N, Masemann D, Pajonczyk D, Brunotte L, Ehrhardt C, Brandenburg LO, Ludwig S, Gerke V, Rescher U. Schloer S, et al. Among authors: brunotte l. FASEB J. 2019 Nov;33(11):12188-12199. doi: 10.1096/fj.201901265R. Epub 2019 Oct 2. FASEB J. 2019. PMID: 31398292 Free PMC article.
Our results indicate a novel protective function of the AnxA1-FPR2 signaling axis in IAV pathology via GM-CSF-associated maintenance of AMs, expanding knowledge on the potential use of proresolving mediators in host defense against pathogens.-Schloer, S., Hubel, N., Masemann, D., …
Our results indicate a novel protective function of the AnxA1-FPR2 signaling axis in IAV pathology via GM-CSF-associated maintenance of AMs, …
Antiviral potential of human IFN-α subtypes against influenza A H3N2 infection in human lung explants reveals subtype-specific activities.
Matos ADR, Wunderlich K, Schloer S, Schughart K, Geffers R, Seders M, Witt M, Christersson A, Wiewrodt R, Wiebe K, Barth P, Hocke A, Hippenstiel S, Hönzke K, Dittmer U, Sutter K, Rescher U, Rodionycheva S, Matera N, Ludwig S, Brunotte L. Matos ADR, et al. Among authors: brunotte l. Emerg Microbes Infect. 2019;8(1):1763-1776. doi: 10.1080/22221751.2019.1698271. Emerg Microbes Infect. 2019. PMID: 31826721 Free PMC article.
Dissecting the mechanism of signaling-triggered nuclear export of newly synthesized influenza virus ribonucleoprotein complexes.
Schreiber A, Boff L, Anhlan D, Krischuns T, Brunotte L, Schuberth C, Wedlich-Söldner R, Drexler H, Ludwig S. Schreiber A, et al. Among authors: brunotte l. Proc Natl Acad Sci U S A. 2020 Jul 14;117(28):16557-16566. doi: 10.1073/pnas.2002828117. Epub 2020 Jun 29. Proc Natl Acad Sci U S A. 2020. PMID: 32601201 Free PMC article.
Targeting the endolysosomal host-SARS-CoV-2 interface by clinically licensed functional inhibitors of acid sphingomyelinase (FIASMA) including the antidepressant fluoxetine.
Schloer S, Brunotte L, Goretzko J, Mecate-Zambrano A, Korthals N, Gerke V, Ludwig S, Rescher U. Schloer S, et al. Among authors: brunotte l. Emerg Microbes Infect. 2020 Dec;9(1):2245-2255. doi: 10.1080/22221751.2020.1829082. Emerg Microbes Infect. 2020. PMID: 32975484 Free PMC article.
Semisynthetic Cardenolides Acting as Antiviral Inhibitors of Influenza A Virus Replication by Preventing Polymerase Complex Formation.
Boff L, Schreiber A, da Rocha Matos A, Del Sarto J, Brunotte L, Munkert J, Melo Ottoni F, Silva Ramos G, Kreis W, Castro Braga F, José Alves R, Maia de Pádua R, Maria Oliveira Simões C, Ludwig S. Boff L, et al. Among authors: brunotte l. Molecules. 2020 Oct 21;25(20):4853. doi: 10.3390/molecules25204853. Molecules. 2020. PMID: 33096707 Free PMC article.
SARS-CoV-2 neutralizing human recombinant antibodies selected from pre-pandemic healthy donors binding at RBD-ACE2 interface.
Bertoglio F, Meier D, Langreder N, Steinke S, Rand U, Simonelli L, Heine PA, Ballmann R, Schneider KT, Roth KDR, Ruschig M, Riese P, Eschke K, Kim Y, Schäckermann D, Pedotti M, Kuhn P, Zock-Emmenthal S, Wöhrle J, Kilb N, Herz T, Becker M, Grasshoff M, Wenzel EV, Russo G, Kröger A, Brunotte L, Ludwig S, Fühner V, Krämer SD, Dübel S, Varani L, Roth G, Čičin-Šain L, Schubert M, Hust M. Bertoglio F, et al. Among authors: brunotte l. Nat Commun. 2021 Mar 11;12(1):1577. doi: 10.1038/s41467-021-21609-2. Nat Commun. 2021. PMID: 33707427 Free PMC article.
40 results