Buchman CD - Search Results

1

Inhibition of the Aldehyde Dehydrogenase 1/2 Family by Psoralen and Coumarin Derivatives.

Buchman CD, Hurley TD. Buchman CD, et al. J Med Chem. 2017 Mar 23;60(6):2439-2455. doi: 10.1021/acs.jmedchem.6b01825. Epub 2017 Mar 6. J Med Chem. 2017. PMID: 28219011 Free PMC article.

2

Structure-Based Optimization of a Novel Class of Aldehyde Dehydrogenase 1A (ALDH1A) Subfamily-Selective Inhibitors as Potential Adjuncts to Ovarian Cancer Chemotherapy.

Huddle BC, Grimley E, Buchman CD, Chtcherbinine M, Debnath B, Mehta P, Yang K, Morgan CA, Li S, Felton J, Sun D, Mehta G, Neamati N, Buckanovich RJ, Hurley TD, Larsen SD. Huddle BC, et al. Among authors: buchman cd. J Med Chem. 2018 Oct 11;61(19):8754-8773. doi: 10.1021/acs.jmedchem.8b00930. Epub 2018 Sep 28. J Med Chem. 2018. PMID: 30221940 Free PMC article.

3

Discovery of a series of aromatic lactones as ALDH1/2-directed inhibitors.

Buchman CD, Mahalingan KK, Hurley TD. Buchman CD, et al. Chem Biol Interact. 2015 Jun 5;234:38-44. doi: 10.1016/j.cbi.2014.12.038. Epub 2015 Jan 29. Chem Biol Interact. 2015. PMID: 25641190 Free PMC article.

4

Enrichment of chemical libraries docked to protein conformational ensembles and application to aldehyde dehydrogenase 2.

Wang B, Buchman CD, Li L, Hurley TD, Meroueh SO. Wang B, et al. Among authors: buchman cd. J Chem Inf Model. 2014 Jul 28;54(7):2105-16. doi: 10.1021/ci5002026. Epub 2014 Jun 30. J Chem Inf Model. 2014. PMID: 24856086 Free PMC article.

5

N,N-diethylaminobenzaldehyde (DEAB) as a substrate and mechanism-based inhibitor for human ALDH isoenzymes.

Morgan CA, Parajuli B, Buchman CD, Dria K, Hurley TD. Morgan CA, et al. Among authors: buchman cd. Chem Biol Interact. 2015 Jun 5;234:18-28. doi: 10.1016/j.cbi.2014.12.008. Epub 2014 Dec 12. Chem Biol Interact. 2015. PMID: 25512087 Free PMC article.

6

A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells.

Chefetz I, Grimley E, Yang K, Hong L, Vinogradova EV, Suciu R, Kovalenko I, Karnak D, Morgan CA, Chtcherbinine M, Buchman C, Huddle B, Barraza S, Morgan M, Bernstein KA, Yoon E, Lombard DB, Bild A, Mehta G, Romero I, Chiang CY, Landen C, Cravatt B, Hurley TD, Larsen SD, Buckanovich RJ. Chefetz I, et al. Cell Rep. 2019 Mar 12;26(11):3061-3075.e6. doi: 10.1016/j.celrep.2019.02.032. Cell Rep. 2019. PMID: 30865894 Free PMC article.

7

Regulation of human and yeast metallothionein gene transcription by heavy metal ions.

Skroch P, Buchman C, Karin M. Skroch P, et al. Prog Clin Biol Res. 1993;380:113-28. Prog Clin Biol Res. 1993. PMID: 8456121 Review. No abstract available.

8

The CUP2 gene product, regulator of yeast metallothionein expression, is a copper-activated DNA-binding protein.

Buchman C, Skroch P, Welch J, Fogel S, Karin M. Buchman C, et al. Mol Cell Biol. 1989 Sep;9(9):4091-5. doi: 10.1128/mcb.9.9.4091-4095.1989. Mol Cell Biol. 1989. PMID: 2674688 Free PMC article.

9

The CUP2 gene product regulates the expression of the CUP1 gene, coding for yeast metallothionein.

Welch J, Fogel S, Buchman C, Karin M. Welch J, et al. EMBO J. 1989 Jan;8(1):255-60. doi: 10.1002/j.1460-2075.1989.tb03371.x. EMBO J. 1989. PMID: 2653812 Free PMC article.

10

A single amino acid change in CUP2 alters its mode of DNA binding.

Buchman C, Skroch P, Dixon W, Tullius TD, Karin M. Buchman C, et al. Mol Cell Biol. 1990 Sep;10(9):4778-87. doi: 10.1128/mcb.10.9.4778-4787.1990. Mol Cell Biol. 1990. PMID: 2167439 Free PMC article.

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