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Is rate of skin wound healing associated with aging or longevity phenotype?
Yanai H, Budovsky A, Tacutu R, Fraifeld VE. Yanai H, et al. Biogerontology. 2011 Dec;12(6):591-7. doi: 10.1007/s10522-011-9343-6. Epub 2011 Jun 12. Biogerontology. 2011. PMID: 21667230
Wound healing (WH) is a fundamental biological process. Is it associated with a longevity or aging phenotype? In an attempt to answer this question, we compared the established mouse models with genetically modified life span and also an altered rate of WH in the sk …
Wound healing (WH) is a fundamental biological process. Is it associated with a longevity or aging phenotype? In an attempt to …
From disease-oriented to aging/longevity-oriented studies.
Budovsky A, Muradian KK, Fraifeld VE. Budovsky A, et al. Rejuvenation Res. 2006 Summer;9(2):207-10. doi: 10.1089/rej.2006.9.207. Rejuvenation Res. 2006. PMID: 16706644
Aging should be considered a major risk factor for life-threatening degenerative pathologies including atherosclerosis, cancer, neurodegeneration, diabetes type II, osteoporosis, and sarcopenia. ...If so, epigenetic interventions may serve in a twofold manner: (a
Aging should be considered a major risk factor for life-threatening degenerative pathologies including atherosclerosis, cancer, neuro …
Mitochondrial genome anatomy and species-specific lifespan.
Lehmann G, Budovsky A, Muradian KK, Fraifeld VE. Lehmann G, et al. Rejuvenation Res. 2006 Summer;9(2):223-6. doi: 10.1089/rej.2006.9.223. Rejuvenation Res. 2006. PMID: 16706648
The results suggest that the MLS may be associated with stability and/or mutability of mtDNA and call for further investigation of the mitochondrial genome as a potential target for lifespan-extending interventions....
The results suggest that the MLS may be associated with stability and/or mutability of mtDNA and call for further investigation of the mitoc …
Longevity network: construction and implications.
Budovsky A, Abramovich A, Cohen R, Chalifa-Caspi V, Fraifeld V. Budovsky A, et al. Mech Ageing Dev. 2007 Jan;128(1):117-24. doi: 10.1016/j.mad.2006.11.018. Epub 2006 Nov 20. Mech Ageing Dev. 2007. PMID: 17116322 Review.
This study is the first attempt towards constructing a "longevity network" via analysis of human protein-protein interactions (PPIs). ...The longevity gene-encoded proteins together with their interacting proteins form a continuous network, which fits the criteria f …
This study is the first attempt towards constructing a "longevity network" via analysis of human protein-protein interactions (PPIs). …
Common gene signature of cancer and longevity.
Budovsky A, Tacutu R, Yanai H, Abramovich A, Wolfson M, Fraifeld V. Budovsky A, et al. Mech Ageing Dev. 2009 Jan-Feb;130(1-2):33-9. doi: 10.1016/j.mad.2008.04.002. Epub 2008 Apr 12. Mech Ageing Dev. 2009. PMID: 18486187
(2) Could they act in cooperative manner at a protein level via protein-protein interactions (PPIs) and, if so, by forming a PPI network? We found that (i) the common genes (both LAGs and CAGs) show the same remarkable trend from yeast to humans: tumor suppressors a …
(2) Could they act in cooperative manner at a protein level via protein-protein interactions (PPIs) and, if so, by forming a P …
The signaling hubs at the crossroad of longevity and age-related disease networks.
Wolfson M, Budovsky A, Tacutu R, Fraifeld V. Wolfson M, et al. Int J Biochem Cell Biol. 2009 Mar;41(3):516-20. doi: 10.1016/j.biocel.2008.08.026. Epub 2008 Aug 29. Int J Biochem Cell Biol. 2009. PMID: 18793745 Review.
These proteins are strongly interconnected and in turn form a common signaling network which comprises over 40% of all hubs (proteins with multiple interactions) in the human interactome. ...
These proteins are strongly interconnected and in turn form a common signaling network which comprises over 40% of all hubs (proteins …
The NetAge database: a compendium of networks for longevity, age-related diseases and associated processes.
Tacutu R, Budovsky A, Fraifeld VE. Tacutu R, et al. Biogerontology. 2010 Aug;11(4):513-22. doi: 10.1007/s10522-010-9265-8. Epub 2010 Feb 26. Biogerontology. 2010. PMID: 20186480
This work was undertaken in order to integrate the data accumulated in the field, from a network-based perspective. The results are organized in the NetAge database-an online database and network analysis tools for biogerontological research ( http://www.netage-project.org …
This work was undertaken in order to integrate the data accumulated in the field, from a network-based perspective. The results are o …
Linking cell polarity, aging and rejuvenation.
Budovsky A, Fraifeld VE, Aronov S. Budovsky A, et al. Biogerontology. 2011 Apr;12(2):167-75. doi: 10.1007/s10522-010-9305-4. Epub 2010 Oct 27. Biogerontology. 2011. PMID: 20978937
Further strengthening the links between cell polarity and aging is a large number of common genes associated with both polarity and longevity. Given a strong similarity between mechanisms of cell polarity in yeast and higher eukaryotes, the budding yeast Saccharomyc …
Further strengthening the links between cell polarity and aging is a large number of common genes associated with both polarity and l …
Gadd45 proteins: relevance to aging, longevity and age-related pathologies.
Moskalev AA, Smit-McBride Z, Shaposhnikov MV, Plyusnina EN, Zhavoronkov A, Budovsky A, Tacutu R, Fraifeld VE. Moskalev AA, et al. Ageing Res Rev. 2012 Jan;11(1):51-66. doi: 10.1016/j.arr.2011.09.003. Epub 2011 Oct 5. Ageing Res Rev. 2012. PMID: 21986581 Free PMC article. Review.
Because of their pleiotropic action, a decreased inducibility of Gadd45 members may have far-reaching consequences including genome instability, accumulation of DNA damage, and disorders in cellular homeostasis - all of which may eventually contribute to the aging process …
Because of their pleiotropic action, a decreased inducibility of Gadd45 members may have far-reaching consequences including genome i …
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