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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1947 1
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1954 1
1955 1
1958 2
1959 2
1961 5
1962 2
1963 3
1964 4
1965 4
1967 2
1968 8
1969 15
1970 22
1971 28
1972 18
1973 12
1974 30
1975 12
1976 9
1977 14
1978 9
1979 7
1980 7
1981 4
1982 5
1983 13
1984 6
1985 12
1986 14
1987 11
1988 9
1989 4
1990 7
1991 16
1992 15
1993 13
1994 10
1995 11
1996 20
1997 18
1998 28
1999 8
2000 19
2001 28
2002 23
2003 12
2004 17
2005 30
2006 36
2007 32
2008 36
2009 34
2010 53
2011 54
2012 71
2013 50
2014 68
2015 66
2016 72
2017 79
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1,791 results

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Page 1
Toad venom bufadienolides and bufotoxins: An updated review.
Asrorov AM, Kayumov M, Mukhamedov N, Yashinov A, Mirakhmetova Z, Huang Y, Yili A, Aisa HA, Tashmukhamedov M, Salikhov S, Mirzaakhmedov S. Asrorov AM, et al. Drug Dev Res. 2023 Aug;84(5):815-838. doi: 10.1002/ddr.22072. Epub 2023 May 8. Drug Dev Res. 2023. PMID: 37154099 Review.
Bufadienolides, naturally found in toad venoms having steroid-like structures, reveal antiproliferative effects at low doses. ...Bufotoxins, derivatives of bufadienolides containing polar molecules mainly belonging to argininyl residues, are reviewed as well. ...
Bufadienolides, naturally found in toad venoms having steroid-like structures, reveal antiproliferative effects at low doses. ...Bufo …
Bufadienolides and their antitumor activity.
Gao H, Popescu R, Kopp B, Wang Z. Gao H, et al. Nat Prod Rep. 2011 May;28(5):953-69. doi: 10.1039/c0np00032a. Epub 2011 Mar 17. Nat Prod Rep. 2011. PMID: 21416078 Review. No abstract available.
Molecular mechanisms of bufadienolides and their novel strategies for cancer treatment.
Deng LJ, Li Y, Qi M, Liu JS, Wang S, Hu LJ, Lei YH, Jiang RW, Chen WM, Qi Q, Tian HY, Han WL, Wu BJ, Chen JX, Ye WC, Zhang DM. Deng LJ, et al. Eur J Pharmacol. 2020 Nov 15;887:173379. doi: 10.1016/j.ejphar.2020.173379. Epub 2020 Aug 3. Eur J Pharmacol. 2020. PMID: 32758567 Review.
Here, we systematically review the anticancer effects of bufadienolides and the molecular or cellular mechanisms of action. Research advancements regarding bufadienolide prodrugs and their tumor-targeting delivery strategies are critically summarized. This work high …
Here, we systematically review the anticancer effects of bufadienolides and the molecular or cellular mechanisms of action. Research …
Novel Strategies for Solubility and Bioavailability Enhancement of Bufadienolides.
Shao H, Li B, Li H, Gao L, Zhang C, Sheng H, Zhu L. Shao H, et al. Molecules. 2021 Dec 22;27(1):51. doi: 10.3390/molecules27010051. Molecules. 2021. PMID: 35011278 Free PMC article. Review.
The strong antitumor effect of bufadienolides has attracted considerable attention in recent years, but the clinical application of bufadienolides is limited due to their low solubility and poor bioavailability. ...This review can provide a basis for further study o …
The strong antitumor effect of bufadienolides has attracted considerable attention in recent years, but the clinical application of …
Bufadienolides as bioorganic anticancer agents: Mechanistic insights into apoptosis, cell cycle arrest and signal pathway modulation.
Hernández-Parra H, Peña-Corona SI, Chávez-Corona JI, Duarte-Peña L, Leyva-Gómez G, Almarhoon ZM, Klimek-Szczykutowicz M, Kubica P, Szopa A, Calina D, Sharifi-Rad J. Hernández-Parra H, et al. Bioorg Chem. 2025 Sep;164:108801. doi: 10.1016/j.bioorg.2025.108801. Epub 2025 Jul 26. Bioorg Chem. 2025. PMID: 40752394 Review.
Bufadienolides, a group of C-24 steroidal compounds found in toad venom and certain plants, have emerged as promising candidates for anticancer drug development due to their broad-spectrum cytotoxicity and multitargeted molecular mechanisms. ...Collectively, current eviden …
Bufadienolides, a group of C-24 steroidal compounds found in toad venom and certain plants, have emerged as promising candidates for …
Bufadienolides from amphibians: A promising source of anticancer prototypes for radical innovation, apoptosis triggering and Na(+)/K(+)-ATPase inhibition.
Sousa LQ, Machado KD, Oliveira SF, Araújo LD, Monção-Filho ED, Melo-Cavalcante AA, Vieira-Júnior GM, Ferreira PM. Sousa LQ, et al. Toxicon. 2017 Mar 1;127:63-76. doi: 10.1016/j.toxicon.2017.01.004. Epub 2017 Jan 7. Toxicon. 2017. PMID: 28069354 Review.
Based on the discovered bioactive potential of bufadienolides, this work reviewed the contribution of amphibians, especially from members of Bufonidae family, as source of new cytotoxic and antitumor molecules, highlighting the mechanisms responsible for such amazing biolo …
Based on the discovered bioactive potential of bufadienolides, this work reviewed the contribution of amphibians, especially from mem …
Total synthesis, chemical modification and structure-activity relationship of bufadienolides.
Zhong Y, Zhao C, Wu WY, Fan TY, Li NG, Chen M, Duan JA, Shi ZH. Zhong Y, et al. Eur J Med Chem. 2020 Mar 1;189:112038. doi: 10.1016/j.ejmech.2020.112038. Epub 2020 Jan 8. Eur J Med Chem. 2020. PMID: 31945667 Review.
Bufadienolides are a type of natural cardiac steroids and originally isolated from the Traditional Chinese Medicine Chan'Su, they have been used for the treatment of heart disease in traditional remedies as well as in modern medicinal therapy with potent anti-tumor activit …
Bufadienolides are a type of natural cardiac steroids and originally isolated from the Traditional Chinese Medicine Chan'Su, they hav …
Bufadienolides of plant and animal origin.
Steyn PS, van Heerden FR. Steyn PS, et al. Nat Prod Rep. 1998 Aug;15(4):397-413. doi: 10.1039/a815397y. Nat Prod Rep. 1998. PMID: 9736996 Review. No abstract available.
Bufadienolides from animal and plant sources.
Krenn L, Kopp B. Krenn L, et al. Phytochemistry. 1998 May;48(1):1-29. doi: 10.1016/s0031-9422(97)00426-3. Phytochemistry. 1998. PMID: 9621450 Review. No abstract available.
Pharmacological insights and role of bufalin (bufadienolides) in inflammation modulation: a narrative review.
Kaur G, Devi S, Sharma A, Sood P. Kaur G, et al. Inflammopharmacology. 2024 Oct;32(5):3057-3077. doi: 10.1007/s10787-024-01517-9. Epub 2024 Jul 16. Inflammopharmacology. 2024. PMID: 39012431 Review.
Bufadienolides, specifically bufalin, have garnered attention for their potential therapeutic application in modulating inflammatory pathways. ...
Bufadienolides, specifically bufalin, have garnered attention for their potential therapeutic application in modulating inflammatory …
1,791 results