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Evolving Rules for Protein Degradation? Insights from the Zinc Finger Degrome.
Biochemistry. 2019 Feb 19;58(7):861-864. doi: 10.1021/acs.biochem.8b01307. Epub 2019 Jan 25.
Biochemistry. 2019.
PMID: 30681837
No abstract available.
Targeting the C481S Ibrutinib-Resistance Mutation in Bruton's Tyrosine Kinase Using PROTAC-Mediated Degradation.
Buhimschi AD, Armstrong HA, Toure M, Jaime-Figueroa S, Chen TL, Lehman AM, Woyach JA, Johnson AJ, Byrd JC, Crews CM.
Buhimschi AD, et al.
Biochemistry. 2018 Jul 3;57(26):3564-3575. doi: 10.1021/acs.biochem.8b00391. Epub 2018 Jun 14.
Biochemistry. 2018.
PMID: 29851337
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Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead.
Bondeson DP, Smith BE, Burslem GM, Buhimschi AD, Hines J, Jaime-Figueroa S, Wang J, Hamman BD, Ishchenko A, Crews CM.
Bondeson DP, et al. Among authors: buhimschi ad.
Cell Chem Biol. 2018 Jan 18;25(1):78-87.e5. doi: 10.1016/j.chembiol.2017.09.010. Epub 2017 Nov 9.
Cell Chem Biol. 2018.
PMID: 29129718
Free PMC article.
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Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties.
Jaime-Figueroa S, Buhimschi AD, Toure M, Hines J, Crews CM.
Jaime-Figueroa S, et al. Among authors: buhimschi ad.
Bioorg Med Chem Lett. 2020 Feb 1;30(3):126877. doi: 10.1016/j.bmcl.2019.126877. Epub 2019 Dec 13.
Bioorg Med Chem Lett. 2020.
PMID: 31879210
Free PMC article.
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An In Vitro Pull-down Assay of the E3 Ligase:PROTAC:Substrate Ternary Complex to Identify Effective PROTACs.
Bondeson DP, Smith BE, Buhimschi AD.
Bondeson DP, et al. Among authors: buhimschi ad.
Methods Mol Biol. 2021;2365:135-150. doi: 10.1007/978-1-0716-1665-9_7.
Methods Mol Biol. 2021.
PMID: 34432242
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Psoralen Derivatives with Enhanced Potency.
Buhimschi AD, Gooden DM, Jing H, Fels DR, Hansen KS, Beyer WF Jr, Dewhirst MW, Walder H, Gasparro FP.
Buhimschi AD, et al.
Photochem Photobiol. 2020 Sep;96(5):1014-1031. doi: 10.1111/php.13263. Epub 2020 Jun 24.
Photochem Photobiol. 2020.
PMID: 32221980
Free PMC article.
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UVA and UVB-Induced 8-Methoxypsoralen Photoadducts and a Novel Method for their Detection by Surface-Enhanced Laser Desorption Ionization Time-of-Flight Mass Spectrometry (SELDI-TOF MS).
Buhimschi AD, Gasparro FP.
Buhimschi AD, et al.
Photochem Photobiol. 2014 Jan;90(1):241-6. doi: 10.1111/php.12171. Epub 2013 Oct 17.
Photochem Photobiol. 2014.
PMID: 24102188
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The Mutational Landscape of Cancer's Vulnerability to Ionizing Radiation.
Gopal P, Yard BD, Petty A, Lal JC, Bera TK, Hoang TQ, Buhimschi AD, Abazeed ME.
Gopal P, et al. Among authors: buhimschi ad.
Clin Cancer Res. 2022 Dec 15;28(24):5343-5358. doi: 10.1158/1078-0432.CCR-22-1914.
Clin Cancer Res. 2022.
PMID: 36222846
Free PMC article.
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