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21 results

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Page 1
Discovery of Kinesin KIF18A Inhibitor ATX020: Tactical Application of Silicon Atom Replacement.
Sparling BA, Lee H, Zablocki MM, Lynes MM, Grigoriu S, Shehaj L, Lockbaum GJ, Khan SK, Hotz T, Lee YT, Buker SM, Gotur D, Lu C, Ribich S, Blakemore SJ, Boriack-Sjodin PA, Silver SJ, Copeland RA, Duncan KW. Sparling BA, et al. Among authors: buker sm. ACS Med Chem Lett. 2025 Oct 27;16(11):2309-2319. doi: 10.1021/acsmedchemlett.5c00512. eCollection 2025 Nov 13. ACS Med Chem Lett. 2025. PMID: 41257005
Discovery of ATX968: An Orally Available Allosteric Inhibitor of DHX9.
Daniels MH, Castro J, Lee YT, Gotur D, Knockenhauer KE, Grigoriu S, Lockbaum GJ, Cheong JE, Lu C, Brennan D, Buker SM, Liu J, Yao S, Sparling BA, Sickmier EA, Ribich S, Blakemore SJ, Silver SJ, Boriack-Sjodin PA, Duncan KW, Copeland RA. Daniels MH, et al. Among authors: buker sm. J Med Chem. 2025 May 8;68(9):9537-9554. doi: 10.1021/acs.jmedchem.5c00252. Epub 2025 Apr 29. J Med Chem. 2025. PMID: 40298172 Free PMC article.
Characterization of exoribonuclease XRN1 as a cancer target and identification of adenosine-3',5'-bisphosphate as a potent enzyme inhibitor.
Lockbaum GJ, Lynes MM, Shen SA, Liu J, Holt N, Nayak SP, Knockenhauer KE, Yao S, Sickmier EA, Raman A, Wu J, Case A, Shehaj L, Buker SM, Grigoriu S, Ribich S, Blakemore SJ, Sparling BA, Duncan KW, Copeland RA, Silver SJ, Boriack-Sjodin PA. Lockbaum GJ, et al. Among authors: buker sm. Commun Biol. 2025 Apr 9;8(1):589. doi: 10.1038/s42003-025-08005-y. Commun Biol. 2025. PMID: 40205031 Free PMC article.
A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair.
Castro J, Daniels MH, Brennan D, Johnston B, Gotur D, Lee YT, Knockenhauer KE, Lu C, Wu J, Nayak S, Collins C, Bansal R, Buker SM, Case A, Liu J, Yao S, Sparling BA, Sickmier EA, Silver SJ, Blakemore SJ, Boriack-Sjodin PA, Duncan KW, Ribich S, Copeland RA. Castro J, et al. Among authors: buker sm. Cancer Res. 2025 Feb 17;85(4):758-776. doi: 10.1158/0008-5472.CAN-24-0397. Cancer Res. 2025. PMID: 39589774 Free PMC article.
Molecular basis of USP7 inhibition by selective small-molecule inhibitors.
Turnbull AP, Ioannidis S, Krajewski WW, Pinto-Fernandez A, Heride C, Martin ACL, Tonkin LM, Townsend EC, Buker SM, Lancia DR, Caravella JA, Toms AV, Charlton TM, Lahdenranta J, Wilker E, Follows BC, Evans NJ, Stead L, Alli C, Zarayskiy VV, Talbot AC, Buckmelter AJ, Wang M, McKinnon CL, Saab F, McGouran JF, Century H, Gersch M, Pittman MS, Marshall CG, Raynham TM, Simcox M, Stewart LMD, McLoughlin SB, Escobedo JA, Bair KW, Dinsmore CJ, Hammonds TR, Kim S, Urbé S, Clague MJ, Kessler BM, Komander D. Turnbull AP, et al. Among authors: buker sm. Nature. 2017 Oct 26;550(7677):481-486. doi: 10.1038/nature24451. Epub 2017 Oct 18. Nature. 2017. PMID: 29045389 Free PMC article.
21 results